Faculty Members

Prof.Abdulaziz Saad Abdulaziz BinSaeedan

Professor Department of Pharmacology College of Pharmacy AL-Kharj

Kharj
011-588-6066
a.binsaeedan@psau.edu.sa

Curriculum Vitae
Publications

Education

Ph. D. (Pharmacology): University of Bradford (Institute of cancer therapeutics), West Yorkshire, England, July 2015.
M. Sc. (Pharmacology) (with distinction): University of Bradford (Institute of cancer therapeutics), West Yorkshire, England, December 2010.
B. Sc. (Pharmaceutical Sciences): College of Pharmacy, King Saud University, Saudi Arabia; May 2005.

Publications

A- Books
1. Abdulaziz Bin Saeedan*, Mohd Nazam Ansari, Amal Almohisen (2023). Chapter 1: Introduction. In: Faris Q.B. Alenzi (Ed.). Molecular Targets and Cancer Therapeutics (part 1): 1-11. Singapore: Bentham science publishers.
2. Hajir A. AL-Saihati*, Mashael Al-Toub, Hanaa I.Sharaf, Manjari Singh, Mohd Nazam Ansari, Abdulaziz Bin Saeedan (2023). Chapter 6: Cell Signaling Pathways in Cancer. In: Faris Q.B. Alenzi (Ed.). Molecular Targets and Cancer Therapeutics (part 1): 242-272. Singapore: Bentham science publishers.
B- Research Publications
1. Abdel-Kader MS, Saeedan AS, Rehman NU, Faqihi HM, Soliman GA. New flavonoids with multiple bronchodilator activity pathways from Tephrosia purpurea L. (Pers.) growing in Saudi Arabia. Saudi Pharm J. 2024 Apr;32(4):101992. doi: 10.1016/j.jsps.2024.101992. Epub 2024 Feb 15. PMID: 38435847; PMCID: PMC10906533
2. Rastogi, S., Ansari, M. N., Saeedan, A. S., Singh, S. K., Mukerjee, A., & Kaithwas, G. Novel furan chalcone modulates PHD‐2 induction to impart antineoplastic effect in mammary gland carcinoma. Journal of Biochemical and Molecular Toxicology, 2024; 38(4), e23679.‏ https://doi.org/10.1002/jbt.23679
3. Lal, D.K.; Kumar, B.; Saeedan, A.S.; Ansari, M.N. An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery. Pharmaceutics 2023, 15, 1187. https://doi.org/10.3390/pharmaceutics15041187
4. Saeedan, A. S., Abdel-Rahman, R. F., Soliman, G. A., Ogaly, H. A., & Abdel-Kader, M. S. Amentoflavone attenuates oxidative stress and neuroinflammation induced by cerebral ischemia/reperfusion in rats by targeting HMGB1-mediated TLR4/NF-κB signaling pathway. Saudi Pharmaceutical Journal, 2023; 31(11), 101798.‏ https://doi.org/10.1016/j.jsps.2023.101798
5. Kumar, A., Yadav, R. K., Shrivastava, N. K., Kumar, R., Kumar, D., Singh, J., Yadav, S., Ansari, M. N., Saeedan, A. S., & Kaithwas, G. Optimization of novel method for isolation of high purity food grade α-linolenic acid from Linum usitatissimum seeds. LWT, 2023; 189, 115466.‏ https://doi.org/10.1016/j.lwt.2023.115466
6. Rastogi, S., Aldosary, S., Saeedan, A. S., Ansari, M. N., Singh, M., & Kaithwas, G. NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment. Frontiers in pharmacology, Switzerland, 2023; 14, 1108915. https://doi.org/10.3389/fphar.2023.1108915
7. Abdulaziz S. Saeedan, Menshawy A. Mohamed, Mai H. Elnaggar, Gamal A. Solimam, Khaled M. Alasiri, Maged S. Abdel-kader 'semisynthetic Theophylline Analogues as Potent Diuretics: An Integrated in vivo and Molecular Docking Study'. Latin American Journal of Pharmacy, Argentina, 2022; 41(7):1408-16. http://www.latamjpharm.org/resumenes/41/7/LAJOP_41_7_1_23.pdf (Impact Factor 0.249).
8. Maged S. Abdel-Kader, Najeeb U. Rehman, Abdullah F. Aldosari, Fahad S. Almutib, Ali I. Al Muwinea, and Abdulaziz S. Saeedan "Bronchodilator Secondary Metabolites from Rhazya stricta Decne Aerial Parts" Separations, Switzerland, 2022 December; 9(12), 412.
9. Abdulaziz S. Saeedan, Ahmad M. Asiri, Jeevan Patra, Jyoti Upadhyay, Mohd Nazam Ansari, Faisal K. Al-Khalifi ‘Synergistic Analgesic Effect of Low Doses of Fluoxetine and Mefenamic Acid Combination: In Silico and In Vivo Studies'. Latin American Journal of Pharmacy, Argentina, 2022 May 28th; 41(7):1308-15. http://www.latamjpharm.org/resumenes/41/7/LAJOP_41_7_1_8.pdf (Impact Factor 0.249).
10. Singh L, Roy S, Kumar A, Rastogi S, Kumar D, Ansari MN, Saeedan AS, Singh M, Kaithwas G. Repurposing Combination Therapy of Voacamine With Vincristine for Downregulation of Hypoxia-Inducible Factor-1α/Fatty Acid Synthase Co-axis and Prolyl Hydroxylase-2 Activation in ER+ Mammary Neoplasia. Frontiers in cell and developmental biology. Switzerland, 2021 Nov 18; 9:736910. https://doi.org/10.3389/fcell.2021.736910 (Impact Factor 6.684).
11. Saeedan AS, Soliman GA, Abdel-Rahman RF, Abd-Elsalam RM, Ogaly HA, Alharthy KM, Abdel-Kader MS. Possible Synergistic Antidiabetic Effects of Quantified Artemisia judaica Extract and Glyburide in Streptozotocin-Induced Diabetic Rats via Restoration of PPAR-α mRNA Expression. Biology, Switzerland, 2021; 10(8):796. https://doi.org/10.3390/biology10080796 (Impact Factor 5.007).
12. Singh L, Bajaj S, Gadewar M, Verma N, Ansari MN, Saeedan AS, Kaithwas G, Singh M. Modulation of Host Immune Response Is an Alternative Strategy to Combat SARS-CoV-2 Pathogenesis. Frontiers in Immunology, Switzerland, 2021 July; 12, https://www.frontiersin.org/articles/10.3389/fimmu.2021.660632/full (Impact Factor 7.561).
13. Mukerjee S, Saeedan AS, Ansari MN, Singh M. Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity. Membranes (Basel), Switzerland, 2021 Jun 28; 11(7): 479. https://www.mdpi.com/2077-0375/11/7/479 (Impact Factor 4.562).
14. Singh L, Singh M, Rastogi S, Choudhary A, Kumar D, Raj R, Ansari MN, Saeedan AS, Kaithwas G. Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma. BMC Mol Cell Biol. England, 2021 Jun 5; 22(1):33. https://bmcmolcellbiol.biomedcentral.com/articles/10.1186/s12860-021-00371-9 (Impact Factor 1.763).
15. Ansari MN, Saeedan AS, Bajaj S, Singh L. “Evaluation of antidiabetic and hypolipidemic activity of Barleria cristata Linn. leaves in alloxan-induced diabetic rats” 3 Biotech, Germany, 2021 March 17; 11: 170. https://link.springer.com/article/10.1007/s13205-021-02728-5 (Impact Factor 2.406).
16. Saeedan AS, Soliman GA, Abdel-Rahman RF, Abd-Elsalam RM, Ogaly HA, Foudah AI, Abdel-Khader MS. “Artemisia judaica L. diminishes diabetes-induced reproductive dysfunction in male rats via activation of Nrf2/HO-1-mediated antioxidant responses” Saudi Journal of Biological Sciences, Netherlands, 2021; 28(3): 1713- 1722. https://www.sciencedirect.com/science/article/pii/S1319562X20306689 (Impact Factor 4.219).
17. Saeedan AS, Rastogi S, Ansari MN. “Roflumilast counteracts DMH-induced preneoplastic colon damage in albino Wistar rats”- Human & Experimental Toxicology, England, 2020 June 11th; 39 (11): 1545-1555. https://journals.sagepub.com/doi/pdf/10.1177/0960327120931165 (Impact Factor 3.30).
18. Saeedan AS, Ganaie MA, Jan BL, Madhkali H, Ansari MN, Rehman NU, Rashid S. Brucine Prevents DMH induced Colon Carcinogenesis in Wistar Rats. International Journal of Pharmacology, Pakistan, 2020; 16(4): 319-329. https://scialert.net/fulltext/?doi=ijp.2020.319.329&org=11 (Impact Factor 0.751).
19. Yadav RK, Singh M, Roy S, Gautam S, Rawat JK, Singh L, Ansari MN, Saeedan AS, Kaithwas G. Short communication: Evaluation of α-linolenic acid-based intramammary nanosuspension for treatment of subclinical mastitis. Journal of Dairy Science, USA, 2020; 103(3): 2701-2706. https://doi.org/10.3168/jds.2019-16239 (Impact Factor 4.034)
20. Rehman NU, Ansari MN, Ganaie MA, Madkhali HA, Saeedan AS, Imam F, Hamad AM. Cadmium-Induced Hepatotoxicity and Oxidative Stress in Rats: Protection by Roflumilast via NF- κB and HO-1 pathway. International Journal of Pharmacology, Pakistan, 2020; 16(2): 154-163. https://scialert.net/fulltext/?doi=ijp.2020.154.163&org=11 (Impact Factor 0.751).
21. Abdel-Kader MS, Soliman GA, Abdel-Rahman RF, Saeedan AS, Abd-Elsalam RM, Ogaly HA. “Effect of olive leaves extract on the antidiabetic effect of glyburide for possible herb-drug interaction”- Saudi Pharmaceutical Journal; Netherlands, 2019 December; 27(8): 1182-1195, https://doi.org/10.1016/j.jsps.2019.10.001 (Impact Factor 4.33).
22. Abdel-Rahman RF, Soliman GA, Saeedan AS, Ogaly HA, Abd-Elsalam HA, Alqasoumi SI, Abdel-Kader MS. “Molecular and biochemical monitoring of the possible herb-drug interaction between Momordica charantia extract and glibenclamide in diabetic rats”- Saudi Pharmaceutical Journal, Netherlands,2019 September; 27(6): 803-816, https://doi.org/10.1016/j.jsps.2019.05.002 (Impact Factor 4.33).
23. Yadav RK, Tripathi CB, Saraf SA, Ansari MN, Saeedan AS, Aldosary S, Rajinikanth PS, Kaithwas G. Alpha-linolenic acid based nano-suspension protect against lipopolysaccharides induced mastitis by inhibiting NFκBp65, HIF-1α, and mitochondria-mediated apoptotic pathway in albino Wistar rats. Toxicology and Applied Pharmacology, USA, 2019 August 15; 377: Article 114628. https://doi.org/10.1016/j.taap.2019.114628 (Impact Factor 4.219)
24. Devi U, Singh M, Roy S, Gupta PS, Ansari MN, Saeedan AS, Kaithwas G. “Activation of prolyl hydroxylase‐2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF‐1α/FASN in ER + breast cancer subtype”- Cell Biochemistry & Function, USA, 2019 June; 37)4:( 216-227, https://doi.org/10.1002/cbf.3389 (Impact Factor 2.186).
25. Ganaie MA, Abdulaziz Al Saeedan, Madhkali H, Jan BL, Khatlani T, Sheikh IA, Rehman MU, Wani K. “Chemopreventive efficacy zingerone (4‐[4‐hydroxy‐3‐methylphenyl] butan‐2‐one) in experimental colon carcinogenesis in Wistar rats”-Environmental Toxicology, USA, 2019 May; 34(5): 610-625, https://doi.org/10.1002/tox.22727 (Impact Factor 4.119).
26. Rawat JK, Roy S, Singh M, Guatam S, Yadav RK, Ansari MN, Aldossary SA, Saeedan AS, Kaithwas G. “Transcutaneous Vagus Nerve Stimulation Regulates the Cholinergic Anti-inflammatory Pathway to Counteract 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis in Albino wistar Rats”- Front. Pharmacol., Switzerland, 2019 May 21; 10: 353 https://doi.org/10.3389/fphar.2019.00353 (Impact Factor 5.81).
27. Soliman GA, Saeedan AS, Abdel-Rahman RF, Ogaly HA. Abd-Elsalam RM, Abdel-Kader MS. “Olive leaves extract attenuates type II diabetes mellitus-induced testicular damage in rats: Molecular and biochemical study”- Saudi Pharmaceutical Journal; Netherlands, 2019 March; 27(3): 326-340, https://doi.org/10.1016/j.jsps.2018.11.015 (Impact Factor 4.33).
28. Devi U, Singh M, Roy S, Tripathi AC, Gupta PS, Saraf SK, Ansari MN, Saeedan AS, Kaithwas G. “PHD-2 activation: a novel strategy to control HIF-1α and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype” Naunyn-Schmiedeberg's Archives of Pharmacology, USA, 2019; 392(10): 1239–1256, https://doi.org/10.1007/s00210-019-01658-7 (Impact Factor 3.12)
29. Manjari Singh, Sweta Kasna, Subhadeep Roy, Sara Aldosary, Abdulaziz S. Saeedan, Mohd. Nazam Ansari & Gaurav Kaithwas “Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signaling”- BMC Cancer, England, 2019; 19(1), Article number: 996. https://doi.org/10.1186/s12885-019-6152-9 (Impact Factor 2.933)
30. Abdulaziz S. Bin Saeedan. Drotaverine produce hypoglycaemia and hypolipidemia in STZ/NA induced diabetic rats through inhibition of phosphodiesterase IV enzyme'. Latin American Journal of Pharmacy, ARGENTINA, August 2018; 37 (11): [In Press] (Impact Factor 0.401).
31. Eldesoky AH, Abdel‐Rahman RF, Ahmed OK, Soliman GA, Saeedan AS, Elzorba HY, Elansary AA, Hattori M. Antioxidant and hepatoprotective potential of Plantago major growing in Egypt and its major phenylethanoid glycoside, acteoside. J Food Biochem, USA, August 2018 [https://doi.org/10.1111/jfbc.12567] (Impact Factor 1.552).
32. Singh L, Aldosary S, Saeedan AS, Ansari MN, Kaithwas G. Prolyl hydroxylase 2: a promising target to inhibit hypoxia-induced cellular metabolism in cancer cells. Drug Discovery Today, ENGLAND, May 2018 (In Press, Corrected Proof) [doi: 10.1016/j.drudis.2018.05.016] (Impact Factor 6.369)
33. Saeedan AS, Singh I, Ansari MN, Singh M, Rawat JK, Devi U, Gautam S, Yadav RK, Kaithwas G. Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats. Inflammopharmacology, SWITZERLAND, August 2018; 26(4): 951-961 [DOI: 10.1007/s10787-017-0440-2], (Impact Factor 3.304).
34. Gautam S, Rani S, Aldossary SA, Saeedan AS, Ansari MN, Kaithwas G. Effects of Phenidone (DuCLOX-2/5 inhibitor) against N-Methyl-N-Nitrosourea induced mammary gland carcinoma in Albino rats. Toxicology and Applied Pharmacology, USA, July 2018; 351: 57-63 (Impact Factor 3.616)
35. Yadav RK, Rawat JK, Gautam S, Singh M, Kumar M, Ansari MN, Roy S, Saeedan AS, Kaithwas G. Antidiabetic activity of mefloquine via GLP-1 receptor modulation against STZ–NA-induced diabetes in albino Wistar rats. 3 Biotech, GERMANY, May 2018; 8(5):240 (Impact Factor 1.497).
36. Al-Saeedan AS, Gautam V, Ansari MN, Singh M, Yadav RK, Rawat JK, Devi U, Gautam S, Roy S, Kaithwas G. Revisiting the Systemic Lipopolysaccharide Mediated Neuroinflammation: Appraising the Effect of L-Cysteine Mediated Hydrogen Sulphide on it. Saudi Pharmaceutical Journal, NETHERLANDS, May 2018; 26(4): 520-527. [DOI:10.1016/j.jsps.2018.02.004], (Impact Factor 2.302)
37. Gautam S, Rawat AK, Sammi SR, Roy S, Singh M, Devi U, Yadav RK, Singh L, Rawat JK, Ansari MN, Saeedan AS, Kumar D, Pandey R, Kaithwas G. DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention. Frontiers in Pharmacology, SWITZERLAND, April 2018; 9: 314. [https://doi.org/10.3389/fphar.2018.00314] (Impact Factor 3.831)
38. Yadav RK, Singh M, Roy S, Ansari MN, Saeedan AS, Kaithwas G. Modulation of oxidative stress response by flaxseed oil: Role of lipid peroxidation and underlying mechanisms. Prostaglandins & Other Lipid Mediators, USA, March 2018; 135: 21-26 (Impact Factor 2.991).
39. Roy S, Singh M, Rawat A, Devi U, Gautam S, Yadav RK, Rawat JK, Ansari MN, Saeedan AS, Kumar D, Kaithwas G. GLA supplementation regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DMBA induced mammary gland carcinoma. Int J Biochem Cell Biol, ENGLAND, March 2018; 96: 51-62, (Impact Factor 3.247).
40. Roy S, Rawat AK, Sammi SR, Devi U, Singh M, Gautam S, Yadav RK, Rawat JK, Singh L, Ansari MN, Saeedan AS, Pandey R, Kumar D, Kaithwas G. Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention. Oncotarget, USA, July 2017; 8(41): 70049-70071 (Impact Factor 5.168).
41. Yadav S, Tiwari V, Singh M, Yadav RK, Roy S, Devi U, Gautam S, Rawat JK, Ansari MN, Saeedan AS, Prakash A, Saraf SA, Kaithwas G. Comparative Efficacy of Alpha Linolenic Acid and Gamma Linolenic Acid to attenuate Valproic acid Induced Autism like features. Journal of Physiology and Biochemistry, NETHERLANDS, May 2017; 73(2): 187-198 (Impact Factor 2.736).
42. Gautam S, Roy S, Ansari MN, Saeedan AS, Saraf SA, Kaithwas G. DuCLOX-2/5 inhibition: a promising target for cancer 3 chemoprevention. Breast Cancer, JAPAN, March 2017; 24(2): 180-190 (Impact Factor 1.772).
43. Devi U, Dubey S, Kumar V, Singh M, Gautum S, Rawat JK, Roy S, Yadav RK, Gupta PS, Ansari MN, Saeedan AS, Kaithwas G. Experimental Models for Autistic Spectrum Disorder-Follow Up For the Validity. Review Journal of Autism and Developmental Disorders, GERMANY; December 2016; 3(4): 358-76. (Impact Factor 1.475).
44. Saeedan AS, Gabr GA, Soliman GA, Fayed MH, Ansari MN. The potential anti-inflammatory and wound healing activities of chitosan in rats. Advances in Bioresearch, INDIA, November 2016; 7(6): 1-7.
45. Soliman GA, Gabr GA, Al-Saikhan FI, Ansari MN, Khan TH, Ganaie MA, Saeedan AS, Özgen Alankuş-Çalışkan. Protective effects of two Astragalus species on ulcerative colitis in rats. Tropical Journal of Pharmaceutical Research, NIGERIA, October 2016; 15(10): 2155-2163 (Impact Factor 0.569).
46. Maged S. Abdel-Kader, Mubarak T. Alanazi , Abdulaziz S. Bin Saeedan , Fahad I. Al-Saikhan, Abubaker M. Hamad. Hepatoprotective and nephroprotective activities of Juniperus sabina L. aerial parts. J Pharm Pharmacogn Res, CHILE, October 2016; 5(1): 29-39, 2017.
47. Rani A, Roy S, Singh M, Devi U, Yadav RK, Gautam S, Rawat JK, Ansari MN, Saeedan AS, Prakash A, Kaithwas G. α-Chymotrypsin Regulates Free Fatty Acids and UCHL-1 to Ameliorate N-Methyl Nitrosourea Induced Mammary Gland Carcinoma in Albino Wistar Rats. Inﬂammopharmacology, SWITZERLAND, October 2016; 24(5): 277-286 [Doi:10.1007/s10787-016-0280-5] (Impact Factor 3.304).
48. Tiwari V, Singh M, Rawat JK, Devi U, Yadav RK, Roy S, Gautam S, Saraf SA, Kumar V, Ansari N, Saeedan AS, Kaithwas G. Redeﬁning the role of peripheral LPS as a neuroinﬂammatory agent and evaluating the role of hydrogen sulphide through metformin intervention. Inﬂammopharmacology, SWITZERLAND, October 2016, 24(5): 253-264 [DOI 10.1007/s10787-016-0274-3] (Impact Factor 3.304).
49. Manral C, Roy S, Singh M, Gautam S, Yadav RK, Rawat JK, Devi U, Ansari MN, Saeedan AS, Kaithwas G. Effect of β-sitosterol against methyl nitrosourea-induced mammary gland carcinoma in albino rats. BMC Complementary and Alternative Medicine, ENGLAND, July 2016; 16(1): 260 [DOI: 10.1186/s12906-016-1243-5] (Impact Factor 2.109).
50. Abdel-Kader MS, Al-Qutaym A, Saeedan AS, Hamad AM, Alkharfy KM. Nephroprotective and hepatoprotective effects of Tribulus terrestris L. growing in Saudi Arabia. J Pharm Pharmacogn Res, CHILE, May 2016; 4(4), 144-152, 2016.
51. Mishra RK, Sammi SR, Rawat JK, Roy S, Singh M, Gautam S, Yadav RK, Devi U, Ansari MN, Saeedan AS, Saraf SA, Pandey R, Kaithwas G (). Palonosetron attenuates 1,2-dimethyl hydrazine induced preneoplastic colon damage through downregulating acetylcholinesterase expression and up-regulating synaptic acetylcholine concentration. RSC Advances, ENGLAND, 2016; 6(46): 40527-40538 (Impact Factor 2.936).
52. Gabr GA, Soliman GA, Ansari MN, Saeedan AS, Hassan NMM. Ameliorative effect of Rumex pictus extract on paracetamol-induced hepatotoxicity in rats. Advances in Bioresearch, INDIA, November 2015; 6(6): 09-15.
53. Gabr GA, Soliman GA, Saeedan AS, Al-Kahtani AA, Ali BE. Teratogenic Effects in Rat Fetuses Subjected to the Concurrent in utero Exposure to Emamectin Benzoate Insecticide. Pakistan J Biol Sci, PAKISTAN, October 2015; 18(7): 333-340

Prof.Abdulaziz Saad Abdulaziz BinSaeedan

Education

Publications

Contact the university leaders

Administration of Public Relations and Media

Social

Faculty Members

Prof.Abdulaziz Saad Abdulaziz BinSaeedan

Education

Publications

Administration of Public Relations and Media