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د.عبدالعزيز سعد عبدالعزيز سعيدان

استاذ مشارك قسم علم الأدوية كلية الصيدلة بالخرج

الخرج
011-588-6066-4210-4310
a.binsaeedan@psau.edu.sa

السيرة الذاتية
الأبحاث العلمية

المؤهلات العلمية

• دكتوراه (علم الأدوية): جامعة برادفورد (معهد علاج السرطان) ، ويست يوركشاير ، إنجلترا ، يوليو 2015. عنوان الرسالة: دور MMP10 في سرطان الرئة ذو الخلايا غير الصغيرة ، والتقييم الدوائي لإمكانيته كهدف للتدخل العلاجي. • ماجستير. (الصيدلة) (بتقدير ممتاز): جامعة برادفورد (معهد علاج السرطان) ، ويست يوركشاير ، إنجلترا ، ديسمبر 2010. عنوان الأطروحة: تقييم السمية الخلوية في المختبر لمجموعة من عوامل استهداف الأوعية الدموية الجديدة (VTAs) • بكالوريوس. (العلوم الصيدلية): كلية الصيدلة ، جامعة الملك سعود ، المملكة العربية السعودية. مايو 2005. عنوان أطروحة السنة النهائية: علم السموم السريرية لدواء Cinacalcet HCL

الأبحاث العلمية

1. AS Saeedan, S Rastogi, MN Ansari “Roflumilast counteracts DMH-induced preneoplastic colon damage in albino Wistar rats”- Human & Experimental Toxicology, vol. 39, 11: pp. 1545-1555, https://doi.org/10.1177/0960327120931165
2. Singh L, Singh M, Ansari MN, Saeedan AS, Kaithwas G “Repurposing Combination Therapy of Voacamine with Vincristine for Down Regulation of HIF-1α/FASN Co-Axis and PHD2 Activation in ER+ Mammary Neoplasia”- Research Square, 10 Jun 2020, DOI: https://doi.org 10.21203/rs.3.rs-34012/v1
3. Uma Devi, Manjari Singh, Subhadeep Roy, Pushpraj S. Gupta, Mohd. Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas “Activation of prolyl hydroxylase‐2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF‐1α/FASN in ER + breast cancer subtype”- Cell Biochemistry, Volume37; Issue4, June 2019: Pages 216-227, https://doi-org.sdl.idm.oclc.org/10.1002/cbf.3389
4. Majid Ahmad Ganaie, Abdulaziz Al Saeedan, Hassan Madhkali, Basit Lateef Jan, Tanvir Khatlani, Ishfaq Ahmad Sheikh, Muneeb U. Rehman, Khalida Wani “Chemopreventive efficacy zingerone (4‐[4‐hydroxy‐3‐methylphenyl] butan‐2‐one) in experimental colon carcinogenesis in Wistar rats”-Environmental Toxicology, Volume34, Issue5, May 2019: Pages 610-625, https://doi-org.sdl.idm.oclc.org/10.1002/tox.22727
5. Jitendra K. Rawat, Subhadeep Roy, Manjari Singh, Swetlana Guatam, Rajnish K. Yadav, Mohd Nazam Ansari, Sara A. Aldossary, Abdulaziz S. Saeedan and Gaurav Kaithwas “Transcutaneous Vagus Nerve Stimulation Regulates the Cholinergic Anti-inflammatory Pathway to Counteract 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis in Albino wistar Rats”- Front. Pharmacol., 21 May 2019, https:// doi.org/10.3389/fphar.2019.00353
6. Gamal A. Solimanab, Abdulaziz S. Saeedan, Rehab F. Abdel-Rahman, Hanan A.Ogaly. Reham M. Abd-Elsalam, Maged S. Abdel-Kader “Olive leaves extract attenuates type II diabetes mellitus-induced testicular damage in rats: Molecular and biochemical study”- Saudi Pharmaceutical Journal; Volume 27, Issue 3, March 2019; Pages 326-340, https://doi.org/10.1016/j.jsps.2018.11.015
7. Maged S. Abdel-Kader, Gamal A. Soliman, Rehab F. Abdel-Rahman, Abdulaziz S. Saeedan, Reham M. Abd-Elsalam, Hanan A.Ogaly “Effect of olive leaves extract on the antidiabetic effect of glyburide for possible herb-drug interaction”- Saudi Pharmaceutical Journal; Volume 27, Issue 8, December 2019: Pages 1182-1195, https://doi.org/10.1016/j.jsps.2019.10.001
8. Rehab F. Abdel-Rahman, Gamal A. Soliman, Abdulaziz S. Saeedan, Hanan A.Ogaly, Reham M. Abd-Elsalam, Saleh I. Alqasoumi, Maged S. Abdel-Kader “Molecular and biochemical monitoring of the possible herb-drug interaction between Momordica charantia extract and glibenclamide in diabetic rats”- Saudi Pharmaceutical Journal; Volume 27, Issue 6, September 2019: Pages 803-816, https://doi.org/10.1016/j.jsps.2019.05.002
9. Uma Devi, Manjari Singh, Subhadeep Roy, Avinash C. Tripathi, Pushpraj S. Gupta, Shailendra K. Saraf, Md. Nazam Ansari, Abdulaziz S. Saeedan & Gaurav Kaithwas “PHD-2 activation: a novel strategy to control HIF-1α and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype” Naunyn-Schmiedeberg's Archives of Pharmacology, volume 392: pages1239–1256(2019), https://link-springer-com.sdl.idm.oclc.org/article/10.1007/s00210-019-01658-7
10. Manjari Singh, Sweta Kasna, Subhadeep Roy, Sara Aldosary, Abdulaziz S. Saeedan, Mohd. Nazam Ansari & Gaurav Kaithwas “Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signaling”- BMC Cancer volume 19, Article number: 996 (2019)
11. Abdulaziz S. Bin Saeedan. Drotaverine produce hypoglycaemia and hypolipidemia in STZ/NA induced diabetic rats through inhibition of phosphodiesterase IV enzyme'. Latin American Journal of Pharmacy, ARGENTINA, August 2018; 37 (11): [In Press] (Impact Factor 0.401).
12. Eldesoky AH, Abdel‐Rahman RF, Ahmed OK, Soliman GA, Saeedan AS, Elzorba HY, Elansary AA, Hattori M. Antioxidant and hepatoprotective potential of Plantago major growing in Egypt and its major phenylethanoid glycoside, acteoside. J Food Biochem, USA, August 2018 [https://doi.org/10.1111/jfbc.12567] (Impact Factor 1.552).
13. Singh L, Aldosary S, Saeedan AS, Ansari MN, Kaithwas G. Prolyl hydroxylase 2: a promising target to inhibit hypoxia-induced cellular metabolism in cancer cells. Drug Discovery Today, ENGLAND, May 2018 (In Press, Corrected Proof) [doi: 10.1016/j.drudis.2018.05.016] (Impact Factor 6.369)
14. Saeedan AS, Singh I, Ansari MN, Singh M, Rawat JK, Devi U, Gautam S, Yadav RK, Kaithwas G. Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats. Inflammopharmacology, SWITZERLAND, August 2018; 26(4): 951-961 [DOI: 10.1007/s10787-017-0440-2], (Impact Factor 3.304).
15. Gautam S, Rani S, Aldossary SA, Saeedan AS, Ansari MN, Kaithwas G. Effects of Phenidone (DuCLOX-2/5 inhibitor) against N-Methyl-N-Nitrosourea induced mammary gland carcinoma in Albino rats. Toxicology and Applied Pharmacology, USA, July 2018; 351: 57-63 (Impact Factor 3.616)
16. Yadav RK, Rawat JK, Gautam S, Singh M, Kumar M, Ansari MN, Roy S, Saeedan AS, Kaithwas G. Antidiabetic activity of mefloquine via GLP-1 receptor modulation against STZ–NA-induced diabetes in albino Wistar rats. 3 Biotech, GERMANY, May 2018; 8(5):240 (Impact Factor 1.497).
17. Al-Saeedan AS, Gautam V, Ansari MN, Singh M, Yadav RK, Rawat JK, Devi U, Gautam S, Roy S, Kaithwas G. Revisiting the Systemic Lipopolysaccharide Mediated Neuroinflammation: Appraising the Effect of L-Cysteine Mediated Hydrogen Sulphide on it. Saudi Pharmaceutical Journal, NETHERLANDS, May 2018; 26(4): 520-527. [DOI:10.1016/j.jsps.2018.02.004], (Impact Factor 2.302)
18. Gautam S, Rawat AK, Sammi SR, Roy S, Singh M, Devi U, Yadav RK, Singh L, Rawat JK, Ansari MN, Saeedan AS, Kumar D, Pandey R, Kaithwas G. DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention. Frontiers in Pharmacology, SWITZERLAND, April 2018; 9: 314. [https://doi.org/10.3389/fphar.2018.00314] (Impact Factor 3.831)
19. Yadav RK, Singh M, Roy S, Ansari MN, Saeedan AS, Kaithwas G. Modulation of oxidative stress response by flaxseed oil: Role of lipid peroxidation and underlying mechanisms. Prostaglandins & Other Lipid Mediators, USA, March 2018; 135: 21-26 (Impact Factor 2.991).
20. Roy S, Singh M, Rawat A, Devi U, Gautam S, Yadav RK, Rawat JK, Ansari MN, Saeedan AS, Kumar D, Kaithwas G. GLA supplementation regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DMBA induced mammary gland carcinoma. Int J Biochem Cell Biol, ENGLAND, March 2018; 96: 51-62, (Impact Factor 3.247).
21. Roy S, Rawat AK, Sammi SR, Devi U, Singh M, Gautam S, Yadav RK, Rawat JK, Singh L, Ansari MN, Saeedan AS, Pandey R, Kumar D, Kaithwas G. Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention. Oncotarget, USA, July 2017; 8(41): 70049-70071 (Impact Factor 5.168).
22. Yadav S, Tiwari V, Singh M, Yadav RK, Roy S, Devi U, Gautam S, Rawat JK, Ansari MN, Saeedan AS, Prakash A, Saraf SA, Kaithwas G. Comparative Efficacy of Alpha Linolenic Acid and Gamma Linolenic Acid to attenuate Valproic acid Induced Autism like features. Journal of Physiology and Biochemistry, NETHERLANDS, May 2017; 73(2): 187-198 (Impact Factor 2.736).
23. Gautam S, Roy S, Ansari MN, Saeedan AS, Saraf SA, Kaithwas G. DuCLOX-2/5 inhibition: a promising target for cancer 3 chemoprevention. Breast Cancer, JAPAN, March 2017; 24(2): 180-190 (Impact Factor 1.772).
24. Devi U, Dubey S, Kumar V, Singh M, Gautum S, Rawat JK, Roy S, Yadav RK, Gupta PS, Ansari MN, Saeedan AS, Kaithwas G. Experimental Models for Autistic Spectrum Disorder-Follow Up For the Validity. Review Journal of Autism and Developmental Disorders, GERMANY; December 2016; 3(4): 358-76. (Impact Factor 1.475).
25. Saeedan AS, Gabr GA, Soliman GA, Fayed MH, Ansari MN. The potential anti-inflammatory and wound healing activities of chitosan in rats. Advances in Bioresearch, INDIA, November 2016; 7(6): 1-7.
26. Soliman GA, Gabr GA, Al-Saikhan FI, Ansari MN, Khan TH, Ganaie MA, Saeedan AS, Özgen Alankuş-Çalışkan. Protective effects of two Astragalus species on ulcerative colitis in rats. Tropical Journal of Pharmaceutical Research, NIGERIA, October 2016; 15(10): 2155-2163 (Impact Factor 0.569).
27. Maged S. Abdel-Kader, Mubarak T. Alanazi , Abdulaziz S. Bin Saeedan , Fahad I. Al-Saikhan, Abubaker M. Hamad. Hepatoprotective and nephroprotective activities of Juniperus sabina L. aerial parts. J Pharm Pharmacogn Res, CHILE, October 2016; 5(1): 29-39, 2017.
28. Rani A, Roy S, Singh M, Devi U, Yadav RK, Gautam S, Rawat JK, Ansari MN, Saeedan AS, Prakash A, Kaithwas G. α-Chymotrypsin Regulates Free Fatty Acids and UCHL-1 to Ameliorate N-Methyl Nitrosourea Induced Mammary Gland Carcinoma in Albino Wistar Rats. Inﬂammopharmacology, SWITZERLAND, October 2016; 24(5): 277-286 [Doi:10.1007/s10787-016-0280-5] (Impact Factor 3.304).
29. Tiwari V, Singh M, Rawat JK, Devi U, Yadav RK, Roy S, Gautam S, Saraf SA, Kumar V, Ansari N, Saeedan AS, Kaithwas G. Redeﬁning the role of peripheral LPS as a neuroinﬂammatory agent and evaluating the role of hydrogen sulphide through metformin intervention. Inﬂammopharmacology, SWITZERLAND, October 2016, 24(5): 253-264 [DOI 10.1007/s10787-016-0274-3] (Impact Factor 3.304).
30. Manral C, Roy S, Singh M, Gautam S, Yadav RK, Rawat JK, Devi U, Ansari MN, Saeedan AS, Kaithwas G. Effect of β-sitosterol against methyl nitrosourea-induced mammary gland carcinoma in albino rats. BMC Complementary and Alternative Medicine, ENGLAND, July 2016; 16(1): 260 [DOI: 10.1186/s12906-016-1243-5] (Impact Factor 2.109).
31. Abdel-Kader MS, Al-Qutaym A, Saeedan AS, Hamad AM, Alkharfy KM. Nephroprotective and hepatoprotective effects of Tribulus terrestris L. growing in Saudi Arabia. J Pharm Pharmacogn Res, CHILE, May 2016; 4(4), 144-152, 2016.
32. Mishra RK, Sammi SR, Rawat JK, Roy S, Singh M, Gautam S, Yadav RK, Devi U, Ansari MN, Saeedan AS, Saraf SA, Pandey R, Kaithwas G (). Palonosetron attenuates 1,2-dimethyl hydrazine induced preneoplastic colon damage through downregulating acetylcholinesterase expression and up-regulating synaptic acetylcholine concentration. RSC Advances, ENGLAND, 2016; 6(46): 40527-40538 (Impact Factor 2.936).
33. Gabr GA, Soliman GA, Ansari MN, Saeedan AS, Hassan NMM. Ameliorative effect of Rumex pictus extract on paracetamol-induced hepatotoxicity in rats. Advances in Bioresearch, INDIA, November 2015; 6(6): 09-15.
34. Gabr GA, Soliman GA, Saeedan AS, Al-Kahtani AA, Ali BE. Teratogenic Effects in Rat Fetuses Subjected to the Concurrent in utero Exposure to Emamectin Benzoate Insecticide. Pakistan J Biol Sci, PAKISTAN, October 2015; 18(7): 333-340.
35. Gamal A. Soliman, Abdulaziz S. Saeedan, Rehab F. Abdel-Rahman, Hanan A. Ogaly, Reham M. Abd-Elsalam, Maged S. Abdel-Kader. Olive leaves extract attenuates type II diabetes mellitus-induced testicular damage in rats: Molecular and biochemical study. Saudi Pharmaceutical Journal. Available online 29 November 2018, https://www.sciencedirect.com/science/article/pii/S1319016418302500

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مواقع أعضاء هيئة التدريس

د.عبدالعزيز سعد عبدالعزيز سعيدان

المؤهلات العلمية

الأبحاث العلمية

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إدارة العلاقات العامة والإعلام

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مواقع أعضاء هيئة التدريس

د.عبدالعزيز سعد عبدالعزيز سعيدان

المؤهلات العلمية

الأبحاث العلمية

إدارة العلاقات العامة والإعلام