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  1. الرئيسية /
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د.نجيب الرحمن فضل رحمن رحمن

أستاذ مشارك كلية الصيدلة بالخرج
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  • 011-588-0115886035
  • n.rehman@psau.edu.sa
  • السيرة الذاتية
  • الأبحاث العلمية

الأبحاث العلمية

  • 1. Noman, M., Qazi, NG., Rehman, NU., Khan, AU., 2022. Pharmacological investigation of brucine anti-ulcer potential. Frontiers in Pharmacology 13:886433. https:// doi.org/ 10.3389/fphar.2022.886433. (IF: 5.988).
  • 2. Rehman, NU., Ansari, MN., Ahmad, W., Ahamad, SR., 2022. Dual inhibition of phosphodiesterase and Ca++ channels explain the medicinal use of Balanites aegyptiaca (L.) in hyperactive gut disorders. Plants-Basel 11(9):1183. https://doi.org/10.3390/plants11091183 (IF: 4.658).
  • 3. Ansari, MN., Soliman, GA., Rehman, NU., Khalid, MD., 2022. Crisaborole loaded nanoemulsion based chitosan gel: formulation, physicochemical characterization, anti-microbial and wound healing studies. Gels, 8(5): 318. https://doi.org/10.3390/gels8050318 (IF: 4.432).
  • 4. Rehman, NU., Ansari, MN., Palla, AH., Karim, A., Imam, F., Raish, M., Hamad, AM, Noman, M., 2022. Myrica salicifolia Hochst. ex A. Rich. suppress acetic acid-induced ulcerative colitis in rats by reducing TNF-alpha and interleukin-6, oxidative stress parameters and improving mucosal protection. Human and Experimental Toxicology 41, 1-14. https://doi.org/10.1177/096032712s21102518 (IF: 3.247).
  • 5. Rehman, NU., Ansari, MN., Amir, M., Ahmad, W., 2022. GC-MS analysis, in vivo and ex vivo antidiarrheal and antispasmodic effects of the methanolic extract of Acacia nilotica. Molecules 27(7), 2107. https://doi.org/10.3390/molecules27072107 (IF: 4.927).
  • 6. Rehman, NU., Ansari, MN., Ahmad, W., Samad, A., 2022. In silico and ex vivo studies on the spasmolytic activities of Fenchone using isolated guinea-pig trachea. Molecules 27(4), 1360. https://doi:10.3390/molecules27041360 (IF: 4.927).
  • 7. Jan, A., Hao, L., Al Kury, LT., Rehman, NU., Alvi, AM., Badshah, H., Ullah, I., Shah, FA., Li, S., 2022. Carveol promotes Nrf2 contribution in depressive disorders through an anti-inflammatory mechanism. Oxidative Medicine and Cellular Longevity, Article ID 4509204, 16 pages https://doi:0.1155/2022/4509204 (IF: 7.310).
  • 8. Abdel-Kader, MS., Rehman, NU., Alghafis, MA., Al-Matri, MA., 2022. Brochodilator Phenylpropanoid Glycosides from the Seeds of Prunus mahaleb L. Records of Natural Products. 5, p 443-453. http://doi.org/10.25135/rnp.303.2111.2270 (IF: 2).
  • 9. Palla, AH., Amin, F., Fatima, B., Shafiq, A., Rehman, NU., Haq, I., Gilani, AH., 2021. Systematic review of Poly-herbals used in metabolic syndrome. Frontiers in Pharmacology 12. https:// doi.org/ 10.3389/fphar.2021.752926 (IF: 5.988).
  • 10. Palla, AH., Rehman, NU., Siddiqi, SH., Gilani, AH., Siddiqui, BS., Ilyas, M., Perwaiz, S., 2021. Cardiac depressant and vasodialatory effect of Flaxseed - basis for the medicinal use in hypertension. Sains Malaysiana 50(9), 2687-2700. https://doi.org/10.17576/jsm-2021-5009-16 (IF: 1.006).
  • 11. Anwar, F., Alkharfy, KM., Mehmood, T., Bakht, MA., Rehman, NU., 2021. Variation in Chemical Composition and Effective Antibacterial Potential of Ocimum basilicum L. Essential Oil Harvested from Different Regions of Saudi Arabia. Pharmaceutical Chemistry Journal 55(2), 187–193. https://doi.org/10.1007/s11094-021-02384-2 (IF: 0.837).
  • 12. Palla, AH., Amin, F., Durrani, N., Rehman, NU., Ikram, R., 2021. Covid-19 pandemic-prevalence of depression, anxiety and insomnia during Covid-19 lockdown and its associated factors in Karachi, Pakistan. Pakistan Journal of Pharmaceutical Sciences 34(4) (SUP), 1597-1605. https://pubmed.ncbi.nlm.nih.gov/34799337/ (IF: 0.684).
  • 13. Alam, A., Rehman, NU., Ansari, MN., Palla, AH., 2021. Effects of essential oils of Elettaria cardamomum grown in India and Guatemala on Gram-negative bacteria and gastrointestinal disorders. Molecules 26, 2546. https://doi.org/10.3390/molecules26092546 (IF: 4.411).
  • 14. Madkhali, AH., Ganaie, MA., Ansari, MN., Alharthy, KM., Rehman, NU., Alamri, MA., Alkholifi, FK., Hamad, AM., Hamadi, A., 2021. Red Yeast Rice Mitigates High-Fat Diet Induced-Obesity Related Vascular Dysfunction in Wistar Albino Rats. Biointerface Research in Applied Chemistry 11(6), 14290 – 14303. https://doi.org/10.33263/BRIAC116.1429014303
  • 15. Rehman, NU., Ansari, MN., Hailea, T., Karim, A., Abujheisha, KY., Ahamad, SR., Imam, F., 2021. Possible tracheal relaxant and antimicrobial effects of the essential oil of Ethiopian thyme specie (Thymus serrulatus Hoschst. Ex Benth.): A multiple mechanistic approach. Frontiers in Pharmacology 12. https:// doi:.org/10.3389/fphar.2021.615228 (IF: 5.810).
  • 16. Ansari, MN., Rehman, NU., Karim, Imam, F., Hamad, AM., 2021. Protective effect of Thymus serrulatus essential oil on cadmium-induced nephrotoxicity in rats, through suppression of oxidative stress and down regulation of NF- κB, iNOS, and Smad2 mRNA expression. Molecules 26(5), 1252. https://doi.org/10.3390/molecules26051252 (IF 4.411).
  • 17. Ansari, MN., Rehman, NU., Karim, A Soliman, GA., Ganaie, MA., Raish, M., 2021. Role of oxidative stress and inflammatory cytokines (TNF-α and IL-6) in acetic acid-induced ulcerative colitis in rats: ameliorated by Otostegia fruticose. Life-Basel 11(3), 195 https://doi.org/10.3390/life11030195 (IF 3.251)
  • 18. Ansari, MJ., Alshetailia, A., Aldayela, IA., Alablana, FM., Alsulaysa, B., Alshahrania, S., Alalaiwea, A., Ansari, MN., Rehman, NU., Shakeel, F., 2020. Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin. Journal of Taibah University for Science 14(1), 1386-1401. https://doi.org/10.1080/16583655.2020.1812269 (IF: 3.459)
  • 19. Anwer, MK., Mohammad, M., Aldawasari, MF., Alshahrani, S., Fatima, F., Ansari, MN., Rehman, NU., Alshdefat, R., 2020. Eluxadoline loaded solid lipid nanoparticles for improved colon targeting in rat model of ulcerative colitis. Pharmaceuticals 19(3), 255. https://doi.org/10.3390/ph13090255 (IF: 5.215)
  • 20. Mohsen S. Al-Omar, Mamuna Naz, Salman A.A. Mohammed, Momina Mansha, Mohammad N. Ansari, Rehman, NU., Kamal, M., Mohammed, HA., Yusuf, M., Hamad, AM., Akhtar, N., Khan, RA., 2020. Pyrethroids-induced organs toxicity and anti-oxidants supplemented amelioration of toxicity and organs damage. International Journal of Environmental Research and Public Health 17, 6177; https://doi.org/10.3390/ijerph17176177 (IF: 4.614).
  • 21. Emiru, YK., Periasamy, G., Karim, A., Rehman, NU., Ansari, MN., 2020. In vitro α-amylase inhibitory activity and in vivo antidiabetic effect of Myrica salicifolia in streptozotocin-induced diabetic mice. Pakistan Journal of Pharmaceutical Sciences 33(4): 1917-1926. https://doi.org/10.36721/PJPS.2020.33.4.SUP.1917-1926.1 (IF: 0.684)
  • 22. Anwar, F., Bakht, A., Geesi, M., Rehman, NU., Adam, EHK., Kamal, M., Ajmal, N., 2020. Compositional variation in volatile constituents and some activities of Thyme essential oils harvested from Saudi Arabia. Latin American Journal of Pharmacy 39(6):1221-1232 (IF: 0.249)
  • 23. Palla, A., Gilani, AH., Bashir, S., Rehman, NU., 2020. Multiple mechanisms of Flaxseed-effectiveness in Inflammatory Bowel disease. Evidence-Based Complementary and Alternative Medicine https://doi.org/10.1155/2020/7974835 (IF: 2.650).
  • 24. Saeedan, AS., Ganaie, MA., Jan, BL., Madhkali, HA., Ansari, MA., Rehman NU., Rashid, S., 2020. Brucine Prevents DMH induced Colon Carcinogenesis in Wistar Rats. International Journal of Pharmacology 16, 319-329. https://doi.org/10.3923/ijp.2020.319.329 (IF: 0.751)
  • 25. Imam F., Rehman NU., Ansari MN., Qamar W., Afzal M., Al-Harbi KS., 2020. Effect of Roflumilast in airways disorders via dual inhibition of Phosphodiesterase and Ca2+-channel. Saudi Pharmaceutical Journal 28, 698-702. https://doi.org/10.1016/j.jsps.2020.04.011 (IF: 4.562).
  • 26. Rehman, NU., Ansari, MN., Samad, A., 2020. In silico, Ex vivo and In vivo studies of Roflumilast as potential Antidiarrheal and Antispasmodic agent: Inhibition of PDE-4 Enzyme and Voltage-gated Ca++ ion Channels. Molecules, 25(4), 1008 https://doi.org/10.3390/molecules25041008 (IF: 4.927).
  • 27. Ansari, MN., Rehman, NU., Karim, A., Bahta, T., Abujheisha, KY., Ahamad, SR., Imam, F., 2020. Evaluation of Bronchodilator and antimicrobial activities of Otostegia fruticose: A multi-mechanistic approach. Saudi Pharmaceutical Journal 28, 281-289. https://doi.org/10.1016/j.jsps.2020.01.007 (IF: 4.562).
  • 28. Rehman, NU., Ansari, MN., Ganaie, MA., Madkhali, HA., Saeedan, AS., Imam, F., Hamad, AM., 2020. Cadmium-Induced Hepatotoxicity and Oxidative Stress in Rats: Protection by Roflumilast via NF- κB and HO-1 pathway. International Journal of Pharmacology 16, 154-163. https://doi.org/10.3923/ijp.2020.154.163 (IF: 0.751)
  • 29. Bahta, T., Karim, A., Periasamy, G., Gebremedhin, G., Rehman, NU., Bitew, H., Hagazi, K., 2020. Analgesic, Anti-inflammatory and In-vitro Hyaluronidase Inhibitory Properties of the Leaf Extract and solvent fractions of Otostegia fruticosa (Forssk.) Schweinf. ex Penzig. Iranian Journal of Pharmaceutical Research 19, 218-230. https://doi.org/10.22037/ijpr.2019.14657.12569 (IF: 1.7).
  • 30. Palla, AH., Sibhat, GG., Karim, A., Rehman, NU., Hiben, MG., 2020. Multiple Pathway-Mediated Gut-Modulatory Effects of Maerua subcordata (Gilg) DeWolf. Journal of Experimental Pharmacology 12, 203-211. https://doi: 10.2147/JEP.S254818. (IF: ?)
  • 31. Ansari, MN., Ganaie, MA., Rehman, NU., Khan, TH., Alharthy, KM., Imam, F., Ansari, MA., Al-Harbi, NO., Jan, BL., Sheikh, IA., Hamad, AM., 2019. Protective role of Roflumilast against cadmium-induced cardiotoxicity through inhibition of oxidative stress and NF-κB signaling in rats. Saudi Pharmaceutical Journal 27, 673-681. https://doi.org/10.1016/j.jsps.2019.04.002 (IF: 4.562).
  • 32. Madkhali, HA., Alharthy, KM., Asiri, MA., Ganaie, MA., Ansari, MN., Rehman, NU., Hamad, AM., 2019. Moringa oleifera Lam. (family Moringaceae) leaf extract attenuates high-fat diet-induced dyslipidemia and vascular endothelium dysfunction in Wistar albino rats. Tropical Journal of Pharmaceutical Research 18, 2597-2604 http://dx.doi.org/10.4314/tjpr.v18i12.20 (IF: 0.533)
  • 33. Anwar, F., Ali, A., Mehmood, T., Gilani, AH., Rehman, NU., 2019. Mentha: A genus rich in vital nutra-pharmaceuticals -A review. Phytotherapy Research 33, 2548-2570 https://doi.org/10.1002/ptr.6423 (IF: 6.388).
  • 34. Ansari, MN., Aloliet, RI., Ganaie, MA., Khan, TH., Rehman, NU., Imam, F., Hamad, AM., 2019. Roflumilast, a phosphodiesterase 4 inhibitor, attenuates cadmium induced renal toxicity via modulation of NF-κB activation and induction of NQO1 in rats. Human & Experimental Toxicology 38, 588-597 https://doi.org/10.1177/0960327119829521 (IF: 2.903)
  • 35. Naz, M., Rehman, NU., Ansari, MN., Kamal, M., Ganaiea, MA., Awaad, AS., Alqasoumi, SI., 2019. Comparative study of subchronic toxicities of mosquito repellents (coils, mats and liquids) on vital organs in Swiss albino mice. Saudi Pharmaceutical Journal 27, 348-353. https://doi.org/10.1016/j.jsps.2018.12.002 (IF: 4.562).
  • 36. Yimer, EM., Tuem, KB., Karim, A., Rehman, NU., Anwar, F., 2019. Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses. Evidence-Based Complementary and Alternative Medicine; 2019:1528635 https://doi.org/10.1155/2019/1528635 (IF: 2.650)
  • 37. Khan, A., Rehman, NU., Gilani, AH., Ahmed, Z., Al-Massarani, S., El-Gamal, A., Farag, M., 2019. Possible Mechanism(s) Underlying the Antidiarrheal, Antispasmodic and Bronchodilatory Activities of the Pericarp of Albizia lebbeck. International Journal of Pharmacology 15, 56-65. https://doi.org/10.3923/ijp.2019.56.65 (IF: 0.751)
  • 38. Anwar, F., Alkharfy, KM., Rehman, NU., Adam, EHK., Gilani, AH., 2017. Chemo-geographical Variations in the Composition of Volatiles and the Biological Attributes of Mentha longifolia (L.) Essential Oils from Saudi Arabia. International Journal of Pharmacology 13, 408-424. https://doi.org/10.3923/ijp.2017.408.424 (IF: 0.751)
  • 39. Aslam, H., Khan, AU., Rehman, NU., Ali, F., Nadeem, H., Shah, SM., 2017. Anti-hyperglycemic activity of Heliotropium strigosum (Boraginaecae) whole plant extract in alloxan-induced diabetic mice. Tropical Journal of Pharmaceutical Research 16, 2425-2430. https://doi.org/10.4314/tjpr.v16i10.16 (IF: 0.533)
  • 40. Arshad, U., Bashir, S., Rehman, NU., Yaqub, T., Gilani, AH., 2016. Dual Inhibition of Ca+2 Influx and Phosphodiesterase Enzyme Provides Scientific Base for the Medicinal Use of Chrozophora prostrata Dalz. in Respiratory Disorders. Phytotherapy Research 30, 1010-5. https://doi.org/ 10.1002/ptr.5610 (IF: 6.388).
  • 41. Khan, H., Saeed, M., Gilani, AH., Muhammad, N., Rehman, NU., Mehmood, MH.,Ashraf, N., 2016. Antispasmodic and antidiarrheal activity of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of K+ channels: components identification through TLC. Toxicology and Industrial Health 32, 677-85. https://doi.org/10.1177/0748233713506956 (IF: 1.851).
  • 42. Aleem, A., Janbaz, KH., Mehmood, MH., Bashir, S., Jawed, F., Rehman, NU., Gilani, AH., 2015. Pharmacological Studies on Antidiarrheal, Gut Modulatory, Bronchodilatory and Vasodilatory Activities of Myrica nagi. International Journal of Pharmacology 10, 225-230. https://doi.org/10.3923/ijp.2015.888.898 (IF: 0.751)
  • 43. Gilani, AH., Rehman, NU., Khan, A., Alkharfy, KM., 2015. Studies on Bronchodilator Activity of Salvia officinalis (Sage): Possible Involvement of K+ Channel Activation and Phosphodiesterase inhibition. Phytotherapy Research 29, 1323-1329. https://doi.org/10.1002/ptr.5384 (IF: 6.388).
  • 44. Rehman, NU., Gilani, AH., Khan, A., Nazneen, M., El Gamal, AA., Fawzy, GA., Al-Ati, HY., Abdel-kader, MS., 2015. Antidiarrhoeal and Antispasmodic Activities of Buddleja polystachya are Mediated through Dual Inhibition of Ca++ influx and Phosphodiesterase Enzyme. Phytotherapy Research 29, 1211-8. https://doi.org/10.1002/ptr.5367 (IF: 6.388).
  • 45. Palla, AH., Khan, NA., Bashir, S., Rehman, NU., Iqbal, J., Gilani, AH., 2015. Pharmacological basis for the medicinal use of Linum usitatisimum (Flaxseed) in infectious and non-infectious diarrhea. Journal of Ethnopharmacology 160, 61-68. https://doi.org/10.1016/j.jep.2014.11.030 (IF: 5.195).
  • 46. Khan, M., Khan, A., Rehman, NU., Gilani, AH., 2014. Blood pressure lowering, vasodilator and cardiac-modulatory potential of Carum roxburghianum seed extract. Clinical and Experimental Hypertension 37, 102-107. https://doi.org/10.3109/10641963.2014.913602 (IF: 1.749).
  • 47. Khan, M., Khan, A., Rehman, NU., Gilani, AH., 2014. Blood pressure lowering effect of Morus alba is mediated through Ca++ antagonist pathway. International Journal of Pharmacology 10, 225-230. https://doi.org/10.3923/ijp.2014.225.230 (IF: 0.751)
  • 48. Khan, M., Khan, A., Rehman, NU., Gilani, AH., 2014. Pharmacological basis for the medicinal use of Lens culinaris in gastrointestinal and respiratory disorders. Phytotherapy Research 28, 1349-58. https://doi.org/10.1002/ptr.5136 (IF: 6.388).
  • 49. Gilani, AH., Khan, M.., Khan, A., Rehman, NU., 2014. Cardiovascular inhibitory properties of Lens culinaris. Bangladesh Journal of Pharmacology 9, 303-306. https://doi.org/10.3329/bjp.v9i3.19090 (IF: 1.143).
  • 50. Muhammad, N., Rehman, NU., Khan, H., Saeed, M., Gilani, AH., 2013. Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant. BMC Complementary and Alternative Medicine 13, 70. https://doi.org/10.1186/1472-6882-13-70. (IF: 3.659).
  • 51. Khan, H., Saeed, M., Mehmood, MH., Rehman, NU., Muhammad, N., Haq, I., Ashraf, N., El-Tahir, KE., Gilani, AH., 2013. Studies on tracheorelaxant and anti-inflammatory activities of rhizomes of Polygonatum verticillatum. BMC Complementary and Alternative Medicine 13, 197. https://doi.org/10.1186/10.1186/1472-6882-13-197. (IF: 3.659).
  • 52. Rehman, NU., Khan, A., Fatima, U., Akram, M., Al-Musayeib, N., Ali El-Gamal, SA., Gilani, AH., 2013. Presence of laxative and antidiarrheal activities in Periploca aphylla: a Saudi medicinal plant. International Journal of Pharmacology 9, 190-196. https://doi.org/10.3923/ijp.2013.190.196 (IF: 0.751)
  • 53. Gilani, AH., Rehman, NU., Mehmood, MH., AlKharfy, KM., 2013. Species differences in the antidiarrheal and antispasmodic activities of Lepidium sativum and insight into underlying mechanisms. Phytotherapy Research 27, 1086-94. https://doi.org/10.1002/ptr.4819 (IF: 6.388).
  • 54. Khan, H., Saeed, M., Gilani, AH., Muhammad, N., Haq, IU., Ashraf, N., Rehman, NU., Haleemi. A., 2013. Antipyretic and anticonvulsant activity of Polygonatum verticillatum: comparison of rhizomes and aerial parts. Phytotherapy Research 27, 468-71. https://doi.org/10.1002/ptr.4721 (IF: 6.388).
  • 55. Mehmood, MH., Rehman, A., Rehman, NU., Gilani, AH., 2013. Studies on prokinetic, laxative and spasmodic activities of Phyllanthus emblica in experimental animals. Phytotherapy Research 27, 1054-60. https://doi.org/10.1002/ptr.4821 (IF: 6.388)
  • 56. Khan, H., Saeed, M., Gilani, AH., Mehmood, MH., Rehman, NU., Muhammad, N., Abbas, M. Haq, IU., 2013. Bronchodilator activity of Aerial parts of Polygonatum verticillatum augmented by anti-inflammatory activity: attenuation of Ca2+ channels and lipoxygenase. Phytotherapy Research 27, 1288-92. https://doi.org/10.1002/ptr.4860 (IF: 6.388).
  • 57. Rehman, NU., Khan, AU., Alkharfy, KM., Gilani, AH., 2012. Pharmacological basis for the medicinal use of Lepidium sativum in airways disorders. Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 596524, 8 pages. https://doi.org/10.1155/2012/596524. (IF: 2.650).
  • 58. Rehman, NU., Mehmood, MH., Alkharfy, KM., Gilani, AH., 2012. Studies on antidiarrheal and antispasmodic activities of Lepidium sativum crude extract in rats. Phytotherapy Research 26, 136-41. https://doi.org/10.1002/ptr.3642 (IF: 6.388).
  • 59. Rehman, NU., Mehmood, MH., Al-Rehaily, AJ., Mothana, RA., Gilani, AH., 2012. Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora. BMC Complementary and Alternative Medicine 10, 12-16. https://doi.org/10.1186/1472-6882-12-16 (IF: 3.659)
  • 60. Rehman, NU., Bashir, S., Al-Rehaily, AJ., Gilani, AH., 2012. Mechanisms underlying the antidiarrheal, antispasmodic and bronchodilator activities of Fumaria parviflora and involvement of tissue and species specificity Journal of Ethnopharmacology 144, 128-137. https://doi.org/ 10.1016/j.jep.2012.08.039 (IF: 5.195).
  • 61. Khan, M., Khan, AU., Rehman, NU., Gilani, AH., 2012. Gut and airways relaxant effects of Carum roxburghianum. Journal of Ethnopharmacology 141, 938-46. https://doi.org/10.1016/j.jep.2012.03.039 (IF: 5.195).
  • 62. Khan, M., Khan, AU., Rehman, NU., Zafar, MA., Hazrat, A., Gilani, AH., 2012. Cardiovascular effects of Juniperus excelsa are mediated through multiple pathways. Clinical and Experimental Hypertension 34, 209-16. https://doi.org/10.3109/10641963.2011.631651 (IF: 1.749).
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