أعضاء هيئة التدريس | مواقع أعضاء هيئة التدريس

د.السيد عبده زكي خفاجي

Ph.D. in Pharmaceutical Sciences (Pharmaceutics) أستاذ مشارك قسم الصيدلانيات كلية الصيدلة بالخرج

الخرج
e.khafagy@psau.edu.sa

السيرة الذاتية
الأبحاث العلمية

الاهتمامات البحثية

• Project 1: Evaluation and Improvement of Transmucosal Drug Absorption by Various Approaches.
• Project 2: Development of Biodrugs Delivery Systems for Non-parenteral Administration.
• Project 3: Applications of Nanotechnology in Biology and Medicine.
• Project 4: Development of Novel Brain Delivery Systems of Psychotropic Biodrugs.
I am currently pursuing the following research projects:
• Project 5: Oral Delivery of Macromolecular Therapies via Reversible Modulation of Intestinal Tight Junctions.
• Project 6: Development of 3D In Vitro Model of Blood-Brain Barrier in Layered Microfluidic Channels.
• Project 7: Improvement of CNS Delivery of Macromolcular Therapies Using CPPs into In Vitro Model of the Blood-Brain Barrier in Layered Microfluidic Channels.
• Project 8: Evaluation the Effect of Pseudomonas aeruginosa Elastase on the Integrity of Epithelial Monolayers.
• Project 9: Modulation of Intracellular Ca2+ Concentration in Brain Microvascular Endothelial Cells In Vitro by Acoustic Cavitation.
• Project 10: Evaluation of the Potential of CPPs in Inhibition of P-glycoprotein (P-gp) Activity by Everted Sac Model.
• Project 11: Development of Nasal Pegylated Biodrugs for Delivery Systems using Cell-Penetrating Peptides.
• Project 12: Development of Oral Delivery Systems for Biopharmaceuticals Based on Innovative CPPs Strategy.
• Project 13: Application of Simplex Lattice Design for Investigating the Effect of Formulation Variables on Critical Attributes of Fast Orodispersible Tablets.
• Project 14: Application of Quality by Design (QbD) Concept for Design and Optimization of Fast Orally Melting Tablets Using Suspension Spray Technique.
• Project 15: Development and Optimize Gastroretentive System Using Simplex Lattice Design for Investigating the Effect of Formulation Variables on Critical Attributes of Oral Tablets.
• Project 16: Enhancement of the therapeutic efficacy of natural plant products via formulation into nano-based drug delivery systems.
• Project 17: New strategies for tackling bacterial infection.

الأبحاث العلمية

1. Nesreen M. Sabry, Tamer M. Naguib, Ahmed M. Kabel*, El-Sayed Khafagy, Hany H. Arab, and Walid A. Almorsy, “Ameliorative potential of L-Alanyl L-Glutamine dipeptide in colon cancer patients receiving modified FOLFOX-6 regarding the incidence of diarrhea, the treatment response, and patients’ survival: A randomized controlled trial”, Medicina, 58(3): 394, 2022. (Impact Factor: 2.430).
2. Ekta Singh*, Riyaz Ali M. Osmani, Rinti Banerjee, Amr Selim Abu Lila, Afrasim Moin, Khaled Almansour, Hany H. Arab, Hadil Faris Alotaibi, and El-Sayed Khafagy, “Poly ε-carpolactone nanoparticles for sustained intra-articular immune modulation in adjuvant-induced arthritis rodent model”, Pharmaceutics, 14(3): 519, 2022. (Impact Factor: 6.321).
3. Turki Al Hagbani, Syed Mohd Danish Rizvi, Talib Hussain, Khalid Mehmood, Zeeshan Rafi, Afrasim Moin*, Amr Selim Abu Lila, Farhan Alshammari, El-Sayed Khafagy, Mohamed Rahamathulla, and Marwa H. Abdallah, “Cefotaxime mediated synthesis of gold nanoparticles: Characterization and antibacterial activity”, Polymers, 14(4): 771, 2022. (Impact Factor: 4.329).
4. Mohamed H. Fayed*, Mohammed F. Aldawsari, Amer S. AlAli, Ahmed Al Saqr, Bjad K. Almutairy, Alhussain H. Aodah, Hesham M. Tawfeek, El-Sayed Khafagy, and Doaa A.Helal, “Design-of-experiment approach to quantify the effect of nano-sized silica on tableting properties of microcrystalline cellulose to facilitate direct compression tableting of binary blend containing a low-dose drug”, Journal of Drug Delivery Science and Technology, 68, 103127, 2022. (Impact Factor: 3.981).
5. Meenakshi Srinivas Iyer, Anil Kumar Gujjari, Sathishbabu Paranthaman, Amr Selim Abu Lila, Khaled Almansour, Farhan Alshammari, El-Sayed Khafagy, Hany H. Arab, and Devegowda Vishakante Gowda*, “Development and evaluation of clove and cinnamon supercritical fluid extracts-loaded emulgel for antifungal activity in denture stomatitis”, Gels, 8(1): 33, 2022. (Impact Factor: 4.702).
6. Marwa H. Abdallah*, Amr S. Abu Lila, Seham Mohammed Shawky, Khaled Almansour, Farhan Alshammari, El-Sayed Khafagy, and Tarek Saad Makram, “Experimental design and optimization of nano-transfersomal gel to enhance the hypoglycemic activity of silymarin”, Polymers, 14(3): 508, 2022. (Impact Factor: 4.329).
7. Turki Al Hagbani, Hemant Yadav, Afrasim Moin, Amr Selim Abu Lila, Khalid Mehmood, Farhan Alshammari, Salman Khan, El-Sayed Khafagy, Talib Hussain*, Syed Mohd Danish Rizvi*, and Marwa H. Abdallah, “Enhancement of vancomycin potential against pathogenic bacterial strains via gold nano-formulations: A nano-antibiotic approach”, Materials, 15(3): 1108, 2022. (Impact Factor: 3.623).
8. Ahmed Al Saqr*, El-Sayed Khafagy, Mohammed F. Aldawsari, Khaled Almansour, and Amr S. Abu Lila, “Screening of apoptosis pathway-mediated anti-proliferative activity of the phytochemical compound furanodienone against human non-small lung cancer A-549 cells”, Life, 12(1): 114, 2022. (Impact Factor: 3.817).
9. Momen Askoura*, Hisham A. Abbas, Hadeel AlSadoun, Wesam H. Abdulaal, Amr S. Abu Lila, Khaled Almansour, Farhan Alshammari, El-Sayed Khafagy, Tarek S. Ibrahim, and Wael A. H. Hegazy*, “Elevated levels of IL-33, IL-17 and IL-25 indicate the progression from chronicity to hepatocellular carcinoma in Hepatitis C virus patients”, Pathogens, 11(1): 57, 2022. (Impact Factor: 3.492).
10. Momen Askoura*, Ahmad J. Almalki, Amr S. Abu Lila, Khaled Almansour, Farhan Alshammari, El-Sayed Khafagy, Tarek S. Ibrahim, and Wael A. H. Hegazy*, “Alteration of Salmonella enterica virulence and host pathogenesis through targeting sdiA by using the CRISPR-Cas9 system”, Microorganisms, 9(12): 2564, 2021. (Impact Factor: 4.128).
11. Ahmed Al Saqr, Mohammed F. Aldawsari, El-Sayed Khafagy*, Moataz A. Shaldam, Wael A. H. Hegazy, and Hisham A. Abbas, “A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa”, Antibiotics, 10(11): 1385, 2021. (Impact Factor: 4.639).
12. Ahdab N. Khayyat, Hisham A. Abbas, Maan T. Khayat, Moataz A. Shaldam, Momen Askoura, Hani Z. Asfour, El-Sayed Khafagy, Amr S. Abu Lila, Ahmed N. Allam and Wael A. H. Hegazy*, “Secnidazole is a promising imidazole mitigator of Serratia marcescens virulence”, Microorganisms, 9(11): 2333, 2021. (Impact Factor: 4.128).
13. Amr S Abu Lila*, Marwa H. Abdallah, El-Sayed Khafagy, Tamer M. Shehata, Mahmoud S. Soliman, Kareem M. Younes, Mohamed Omran, and Shadeed Gad, “Design, synthesis and cytotoxic evaluation of 2-amino-4-aryl-6-substituted pyridine-3,5-dicarbonitrile derivatives”, Tropical Journal of Pharmaceutical Research, 20(10): 2127-2133, 2021. (Impact Factor: 0.533).
14. Amr S.Abu Lila*, Marwa H. Abdallah, Shahid Ud Din Wani, H.V. Gangadharappa, Kareem M. Younes, El-Sayed Khafagy, Tamer M. Shehata, and Mahmoud S. Solimanai, “Folic acid-conjugated raloxifene-loaded graphene-based nanocarrier: Fabrication, characterization and antitumor screening”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 625: 126971, 2021. (Impact Factor: 3.990).
15. Ahdab N. Khayyat, Hisham A. Abbas, Mamdouh F. A. Mohamed, Hani Z. Asfour, Maan T. Khayat, Tarek S. Ibrahim, Mahmoud Youns, El-Sayed Khafagy, Amr S. Abu Lila, Martin K. Safo, and Wael A. H. Hegazy, “Not only antimicrobial: Metronidazole mitigates the virulence of proteus mirabilis isolated from macerated diabetic foot ulcer”, Applied Sciences, 11(15): 6847, 2021. (Impact Factor: 2.679).
16. Mohammed F. Aldawsari, El-Sayed Khafagy*, Ahmed Al Saqr, Ahmed Alalaiwe, Hisham A. Abbas, Moataz A. Shaldam, Wael A. H. Hegazy, and Reham M. Goda, “Tackling virulence of pseudomonas aeruginosa by the natural furanone sotolon”, Antibiotics, 10(7): 871, 2021. (Impact Factor: 4.639).
17. Mohammed F. Aldawsari, Ahmed Alalaiwe, El-Sayed Khafagy*, Ahmed Al Saqr, Saad M. Alshahrani, Bader B. Alsulays, Sultan Alshehri, Amr S. Abu Lila, Syed Mohd Danish Rizvi, and Wael A. H. Hegazy, “Efficacy of SPG-ODN 1826 nanovehicles in inducing M1 phenotype through TLR-9 activation in murine alveolar J774A.1 cells: Plausible nano-immunotherapy for lung carcinoma”, International Journal of Molecular Sciences, 22(13): 6833, 2021. (Impact Factor: 4.556).
18. Amr S. Abu Lila*, Mahmoud S. Soliman, H. C. Kiran, H. V. Gangadharappa, Kareem M. Younes, El-Sayed Khafagy, Tamer M. Shehata, Mahmoud M. Ibrahim, and Marwa H. Abdallah, “Tamoxifen-loaded functionalized graphene nanoribbons for breast cancer therapy”, Journal of Drug Delivery Science and Technology, 63: 102499, 2021. (Impact Factor: 2.734).
19. Ahmed Al Saqr*, Shahid Ud Din Wani, H. V. Gangadharappa, Mohammed F. Aldawsari, El-Sayed Khafagy, and Amr S. Abu Lila, “Enhanced cytotoxic activity of docetaxel-loaded silk fibroin nanoparticles against breast cancer cells”, Polymers, 13(9): 1416, 2021. (Impact Factor: 3.426).
20. Rohit R. Bhosale, Riyaz Ali M. Osmani, Amr S. Abu Lila, El-Sayed Khafagy, Hany H. Arab, Devegowda V. Gowda, Mohamed Rahamathulla, Umme Hani, Mohd Adnanj, and Hosahalli V. Gangadharappa*, “Ghatti gum-base graft copolymer: a plausible platform for pH-controlled delivery of antidiabetic drugs”, RSC Advances, 11(24): 14871–14882, 2021. (Impact Factor: 3.119).
21. Ahdab N. Khayyat, Wael A. H. Hegazy*, Moataz A. Shaldam, Rasha Mosbah, Ahmad J. Almalki, Tarek S. Ibrahim, Maan T. Khayat, El-Sayed Khafagy, Wafaa E. Soliman, and Hisham A. Abbas, “Xylitol inhibits growth and blocks virulence in serratia marcescens”, Microorganisms, 9(5): 1083, 2021. (Impact Factor: 4.152).
22. Ahmed Al Saqr, El-Sayed Khafagy, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Md. Khalid Anwer, Salman Khan, Amr S. Abu Lila, Hany H. Arab, and Wael A. H. Hegazy*, “Synthesis of gold nanoparticles by using green machinery: characterization and in vitro toxicity”, Nanomaterials, 11(3): 808, 2021. (Impact Factor: 4.324).
23. Afrasim Moin, Shahid Ud Din Wani*, Riyaz Ali Osmani, Amr S. Abu Lila, El-Sayed Khafagy, Hany H. Arab, Hosahalli V. Gangadharappa, Ahmed N. Allam, “Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer”, Drug Delivery, 28(1): 1626–1636, 2021. (Impact Factor: 6.419).
24. Bhavya Vishwa, Afrasim Moin, D. V. Gowda*, Syed M. D. Rizvi, Wael A. H. Hegazy, Amr S. Abu Lila, El-Sayed Khafagy, and Ahmed N. Allam*, “Pulmonary targeting of inhalable moxifloxacin microspheres for effective management of tuberculosis”, Pharmaceutics, 13(1): 79, 2021. (Impact Factor: 4.421).
25. Mahmoud Youns*, Momen Askoura, Hisham A. Abbas, Gouda H. Attia, Ahdab N. Khayyat, Reham M. Goda, Ahmad J. Almalki, El-Sayed Khafagy, Wael A.H. Hegazy, “Celastrol modulates multiple signaling pathways to inhibit proliferation of pancreatic cancer via DDIT3 and ATF3 up-regulation and RRM2 and MCM4 down-regulation”, OncoTargets and Therapy, 14: 3849–3860, 2021. (Impact Factor: 4.147).
26. Nahed Mohamed Sallam, Rania Abdel Basset Sanad, Mahgoub Mohamed Ahmed, El-Sayed Khafagy, Mamdouh Ghorab, and Shadeed Gad*, “Impact of the mucoadhesive lyophilized wafer loaded with novel carvedilol nano-spanlastics on biochemical markers in the heart of spontaneously hypertensive rat models”, Drug Delivery and Translational Research, 11(3): 1009–1036, 2021. (Impact Factor: 2.664).
27. Mohamed H. Desoqi, Hossam S. El-Sawy, El-Sayed Khafagy, Mamdouh Ghorab, and Shadeed Gad*, “Drug delivery systems for topical treatment of inflammatory skin diseases”, Records of Pharmaceutical and Biomedical Sciences, 5(1): 59–64, 2021.
28. Mohamed H. Desoqi, Hossam S. El-Sawy*, El-Sayed Khafagy, Mamdouh Ghorab, and Shadeed Gad, “Fluticasone propionate–loaded solid lipid nanoparticles with augmented anti-inflammatory activity: optimisation, characterisation and pharmacodynamic evaluation on rats”, Journal of Microencapsulation, 38(3): 177–191, 2021. (Impact Factor: 2.287).
29. Nahed Mohamed Sallam, Rania Abdel Basset Sanad, El-Sayed Khafagy, Mahgoub Mohamed Ahmed, Mamdouh Ghorab, and Shadeed Gad*, “Colloidal delivery of drugs: present strategies and conditions”, Records of Pharmaceutical and Biomedical Sciences, 5(1):40–51, 2021.
30. Radwa M. Abd-Elal, Ghada H. Elosaily, El-Sayed Khafagy, Yasser Mostafa, and Shadeed Gad*, “Drug delivery from microsponges: A review article”, Records of Pharmaceutical and Biomedical Sciences, 5(1): 21–27, 2021.
31. Bjad K. Almutairy*, El-Sayed Khafagy, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Bader B. Alsulays, Abdullah S. Alshetaili, Sultan M. Alshehri, and Mohamed H. Fayed*, “Enhancing the poor flow and tableting problems of high drug-loading formulation of canagliflozin using continuous green granulation process and design-of-experiment approach”, Pharmaceuticals, 13(12): 473, 2020. (Impact Factor: 4.286).
32. Passant M. Al-Maghrabi, El-Sayed Khafagy, Mamdouh Ghorab, and Shadeed Gad*, “Influence of formulation variables on miconazole nitrate–loaded lipid based nanocarrier for topical delivery”, Colloids and Surfaces B: Biointerfaces, 193: 111046, 2020. (Impact Factor: 4.389).
33. Alhussain H. Aodah*, Mohamed H. Fayed, Ahmed Alalaiwe, Bader B. Alsulays, Mohammed F. Aldawsari, and El-Sayed Khafagy, “Design, optimization, and correlation of in vitro/in vivo disintegration of novel fast orally disintegrating tablet of high dose metformin hydrochloride using moisture activated dry granulation process and quality by design approach”, Pharmaceutics, 12(7): 598, 2020. (Impact Factor: 4.421).
34. El-Sayed Khafagy⁠⁠∗, Mohamed H. Fayed⁠, Shadeed Gad, Saad M. Alshahrani⁠, and Mohammed Aldawsari, “Defining design space for optimization of escitalopram ultra-fast melting tablet using suspension spray-coating technique: In-vitro and in-vivo evaluation”, Journal of Drug Delivery Science and Technology, 57: 101631, 2020. (Impact Factor: 2.734).
35. Passant M. Al-Maghrabi, Shadeed Gad, El-Sayed Khafagy, and Mamdouh Ghorab*, “Solid lipid nanoparticles: a prospective approach for topical drug delivery”, Records of Pharmaceutical and Biomedical Sciences, 4(2): 8–16, 2020.
36. El-Sayed Khafagy, Noriyasu Kamei, Yui Fujiwara, Haruka Okumura, Teruyo Yuasa, Masahiro Kato, Kenji Arime, Anna Nonomura, Hideyuki Ogino, Serena Hirano, Sayaka Sugano, and MarikoTakeda-Morishita*, “Systemic and brain delivery of leptin via intranasal coadministration with cell-penetrating peptides and its therapeutic potential for obesity”, Journal of Controlled Release, 319: 397–406, 2020. (Impact Factor: 7.727).
37. Radwa M. Abd-Elal, Ghada H. Elosaily*, Shadeed Gad, El-Sayed Khafagy, and Yasser Mostafa, “Full factorial design, optimization, in vitro and ex vivo studies of ocular timolol-loaded microsponges”, Journal of Pharmaceutical Innovation, 15(4): 651–663, 2020. (Impact Factor: 1.692).
38. Ahmed Alalaiwe⁠, Mohamed H. Fayed⁠, Saad M. Alshahrani⁠, Bader B. Alsulays⁠, Abdullah S. Alshetaili⁠, Hesham M. Tawfeek⁠, and El-Sayed Khafagy⁠⁠∗, “Application of design of experiment approach for investigating the effect of partially pre-gelatinized starch on critical quality attributes of rapid orally disintegrating tablets”, Journal of Drug Delivery Science and Technology, 49: 227–234, 2019. (Impact Factor: 2.734).
39. Marwa H. Abdallah*, Amr S. Abu Lila, Md. Khalid Anwer, El-Sayed Khafagy, Muqtader Mohammad, and Mahmoud S. Soliman, “Formulation, development and evaluation of Ibuprofen loaded nano-transferosomal gel for the treatment of psoriasis”, Journal of Pharmaceutical Research International, 31(6): 1–8, 2019.
40. Bader B. Alsulays, Md Khalid Anwer, Gamal A. Soliman, Sultan M. Alshehri, and El-Sayed Khafagy⁠⁠∗, “Impact of penetratin stereochemistry on the oral bioavailability of insulin-loaded solid lipid nanoparticles”, International Journal of Nanomedicine, 14: 9127–9138, 2019. (Impact Factor: 5.115).
41. Ahmed Gardouh*, El-Sayed Khafagy⁠⁠, and Mohamed Elkady, “Preparation of self-flocculated solid lipid nanoparticles”, Journal of Research in Pharmacy, 23(4): 652–661, 2019.
42. Khaled M. Darwish, Ismail Salama, Samia Mostafa, Mohamed S. Gomaa, El-Sayed Khafagy, and Mohamed A. Helal*, “Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-γ/FFAR1 agonists”, Bioorganic & Medicinal Chemistry Letters, 28(9): 1595–1602, 2018. (Impact Factor: 2.572).
43. Yu Fukuoka, El-Sayed Khafagy, Takahiro Goto, Noriyasu Kamei, Kozo Takayama, Nicholas A Peppas, and Mariko Takeda-Morishita*, “Combination strategy with complexation hydrogels and cell-penetrating peptides for oral delivery of insulin”, Biological and Pharmaceutical Bulletin, 41(5): 811–814, 2018. (Impact Factor: 1.863).
44. El-Sayed Khafagy, Mona Al-Azab, and Mohamed E.H. ElSayed*, “Rhamnolipids enhance in vivo oral bioavailability of poorly absorbed molecules”, Pharmaceutical Research, 34(10): 2197–2210, 2017. (Impact Factor: 3.242).
45. Noriyasu Kamei, El-Sayed Khafagy, Jun Hirose, and Mariko Takeda-Morishita*, “Potential of single cationic amino acid molecule “Arginine” for stimulating oral absorption of insulin”, International Journal of Pharmaceutics, 521(1-2): 176–183, 2017. (Impact Factor: 4.845).
46. Yuko Iwase, Noriyasu Kamei, El-Sayed Khafagy, Mitsuko Miyamoto, and Mariko Takeda-Morishita*, “Use of a non-covalent cell-penetrating peptides strategy to enhance the nasal delivery of interferon beta and its PEGylated form”, International Journal of Pharmaceutics, 510(1): 304–310, 2016. (Impact Factor: 4.845).
47. Jack D. Wang, El-Sayed Khafagy, Shuichi Takayama, and Mohamed E.H. ElSayed*, "Organization of endothelial cells, pericytes, and astrocytes into a 3D microfluidic in vitro model of the blood-brain barrier", Molecular Pharmaceutics, 13(3): 895–906, 2016. (Impact Factor: 4.321).
48. El-Sayed Khafagy, Ruisha Iwamae, Noriyasu Kamei, and Mariko Takeda-Morishita*, “Region-dependent role of the cell-penetrating peptides in insulin permeation across rat small intestinal membrane”, The AAPS Journal, 17(6): 1427–1437, 2015. (Impact Factor: 3.737).
49. Noriyasu Kamei, Yukina Aoyama, El-Sayed Khafagy, Mao Henmi, and Mariko Takeda-Morishita*, “Effect of different intestinal conditions on the intermolecular interaction between insulin and cell-penetrating peptide penetratin and on its contribution to stimulation of permeation through intestinal epithelium”, European Journal of Pharmaceutics and Biopharmaceutics, 94: 42–51, 2015. (Impact Factor: 4.604).
50. Mamdouh Ghorab*, Ahmed Nassar, El-Sayed Khafagy, Shadeed Gad, “A pharmaceutical study of various additives on itraconazole as solubilized systems for ocular delivery”, World Journal of Pharmaceutical Research, 4(10): 61–89,2015.
51. Sahar M. Fayez*, Shadeed G. Shadeed, El-Sayed A. Khafagy, Gehad A. Abdeljaleel, Mamdouh M. Ghorab, Sohier A. El-Nahhas, “Formulation and evaluation of etodolac lecithin organogel transdermal delivery systems”, International Journal of Pharmaceutics and Pharmaceutical Sciences, 7(4): 325–334, 2015.
52. Ebbe Juel Bech Nielsen, Shinya Yoshida, Noriyasu Kamei, Ruisha Iwamae, El-Sayed Khafagy, Jørgen Olsen, Ulrik Lytt Rahbek, Betty Lomstein Pedersen, Kozo Takayama and Mariko Takeda-Morishita*, “In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin”, Journal of Controlled Release, 189: 19–24, 2014 (Impact Factor: 7.727).
53. El-Sayed Khafagy, Noriyasu Kamei, Ebbe Juel Nielsen, Nobuo Ida and Mariko Takeda-Morishita*, “One-month subchronic toxicity study of cell-penetrating peptides on insulin nasal delivery in rats”, European Journal of Pharmaceutics and Biopharmaceutics, 85(3): 736–743, 2013. (Impact Factor: 4.604).
54. Noriyasu Kamei, Ebbe Juel Nielsen, El-Sayed Khafagy and Mariko Takeda-Morishita*, “Noninvasive insulin delivery: the great potential of cell-penetrating peptides”, Therapeutic Delivery, 4(3): 315–326, 2013.
55. El-Sayed Khafagy, Noriyasu Kamei and Mariko Morishita*, “Cell-penetrating peptide-biodrug strategy for oral and nasal delivery: review of recent findings”, Journal of Experimental and Clinical Medicine, 4(4): 198–202, 2012.
56. El-Sayed Khafagy, and Mariko Morishita*, “Oral biodrug delivery using cell-penetrating peptide”, Advanced Drug Delivery Reviews, 64(6): 531–539, 2012. (Impact Factor: 13.3).
57. Mamdouh Ghorab, El-Sayed Khafagy, Mariam Kamel, and Shadeed Gad*, “Formulation, characterization and comparative in vitro in vivo evaluation of sustained release theophylline tablets”, International Journal of Pharmaceutics and Pharmaceutical Sciences, 4(3): 721–728, 2012.
58. El-Sayed Khafagy, Mariko Morishita*, and Kozo Takayama, “The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides”, International Journal of Pharmaceutics, 388(1-2): 209–212, 2010. (Impact Factor: 4.845).
59. El-Sayed Khafagy, Mariko Morishita*, Nobuo Ida, Reiji Nishio, Koichi Isowa, and Kozo Takayama, “Structural requirements of penetratin absorption enhancement efficiency for insulin delivery”, Journal of Controlled Release, 143(3): 302–310, 2010. (Impact Factor: 7.727).
60. El-Sayed Khafagy, Mariko Morishita*, Noriyasu Kamei, Yoshimi Eda, Yohei Ikeno, and Kozo Takayama, “Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins”, International Journal of Pharmaceutics, 381(1): 49–55, 2009. (Impact Factor: 4.845).
61. El-Sayed Khafagy, Mariko Morishita*, Koichi Isowa, Jun Imai, and Kozo Takayama, Effect of cell-penetrating peptides on the nasal absorption of insulin, Journal of Controlled Release, 133(2): 103–108, 2009. (Impact Factor: 7.727).
62. El-Sayed Khafagy, Mariko Morishita*, Yoshinori Onuki, and Kozo Takayama, “Current challenges in non-invasive insulin delivery systems: a comparative review”, Advanced Drug Delivery Reviews, 59 (15): 1521–1546, 2007. (Impact Factor: 13.3).
Chapter in Book:
63. Mariko Morishita, El-Sayed Khafagy*, J. Shofner, and N.A. Peppas, Oral delivery systems. In: M. Morishita, K. Park (Eds.), “Biodrug delivery systems: fundamentals, applications and clinical development”, 1st edn., Informa Health Care, London, UK (2009), pp. 172–186.

مواقع أعضاء هيئة التدريس

د.السيد عبده زكي خفاجي

الاهتمامات البحثية

الأبحاث العلمية

تواصل مع قيادات الجامعة

إدارة العلاقات العامة والإعلام

Social

مواقع أعضاء هيئة التدريس

د.السيد عبده زكي خفاجي

الاهتمامات البحثية

الأبحاث العلمية

إدارة العلاقات العامة والإعلام