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مواقع أعضاء هيئة التدريس

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د.منشاوى عزمي منشاوى محمد

دكتوراة بالكيمياء العضوية الصيدلية أستاذ مشارك كلية الصيدلة بالخرج

الخرج
011-588-6025
ma.mohamed@psau.edu.sa

السيرة الذاتية
الأبحاث العلمية

الاهتمامات البحثية

تصميم وتطوير الدواء

الأبحاث العلمية

1) Synthesis, Anticancer Screening of Some Novel Trimethoxy Quinazolines and VEGFR2, EGFR Tyrosine Kinase Inhibitors Assay; Molecular Docking Studies , Abdulmalik S. Altamimi , Adel S. El-Azab , Sami G. Abdelhamid , Mubarak A. Alamri , Ashraf H. Bayoumi , Safar M. Alqahtani , Alhumaidi B. Alabbas , Ali I. Altharawi , Manal A. Alossaimi, Menshawy A. Mohamed, Molecules 2021, 26, 2992. https://doi.org/10.3390/26102992.
2) Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors. Adel S. El-Azab , Alaa A.-M. Abdel-Aziza , Sivia Buab , Alessio Nocentinib , Manal A. El-Gendya , Menshawy A. Mohamed , Taghreed Z. Shawere , Nawaf A. AlSaifa , Claudiu T. Supuranb, Bioorganic Chemistry 87 (2019) 78–90.
3) Sonochemistry (Applications of Ultrasound in Chemical Synthesis and Reactions): A Review Part III, Menshawy A. Mohamed, Journal of Pharmaceutical Research International, 31(6): 1-19, 2019.
4) SYNTHESIS AND EVALUATION OF SOME UMBELLIFERONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, Menshawy A. Mohamed, Adnan A. Beckeit , Adel S. El-Azab , Ghada F. Mohamed , Sami G. Abdel-Hamid , and Maged S. Abdel-Kader, IAJPS 2018, 05 (12), 16165-16177.
5) Determination of Cefoxitin Sodium in Presence of Its Alkaliinduced Degradation Product Using a Univariate Constant Center Spectrophotometric Method and Three Multivariate Chemometric Methods: A Comparative Study, Ahmed I. Foudah, Ghada F. Mohamed,Menshawy A.Mohamed, Sami G. Abdel-hamid, Adv. Biores., Vol 9 (4) July 2018: 155-166.
6) Spectroscopic and reactive properties of a newly synthesized quinazoline derivative: Combined experimental, DFT, molecular dynamics and docking study. Adel S. El-Azab , Y. Shyma Mary , Y. Sheena Mary , C. Yohannan Panicker , Alaa A.-M. Abdel-Aziz , Menshawy A. Mohamed , Stevan Armakovi , Sanja J. Armakovi , Christian Van Alsenoy, Journal of Molecular Structure 1134 (2017) 863-881.
7) Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties. Menshawy A. Mohamed , Alaa A.-M. Abdel-Aziz , Helmy M. Sakr , Adel S. El-Azab , Silvia Bua , Claudiu T. Supuran, Bioorganic & Medicinal Chemistry 25 (2017) 2524–2529.
8) Sonochemistry (Applications of Ultrasound in Chemical Synthesis and Reactions): A Review Part II, Menshawy A. Mohamed, Adv. Biores., Vol 8 (3) May 2017: 01-11.
9) Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies. Alaa A.-M. Abdel-Aziz , Laila A. Abou-Zeid , Kamal Eldin H. ElTahir , Menshawy A. Mohamed , Mohamed A. Abu El-Enin , Adel S. El-Azab, Bioorg. Med. Chem. 24 (2016) 3818–3828.
10) Synthesis and antitumor evaluation of trimethoxyanilides based on 4(3H)-quinazolinone scaffolds. Menshawy A. Mohamed , Rezk R. Ayyad , Taghreed Z. Shawer , Alaa A.-M. Abdel-Aziz , Adel S. El-Azab. European Journal of Medicinal Chemistry 112 (2016) 106-113
11) Synthesis, antitumor activity and molecular docking study of some novel 3- benzyl-4(3H)quinazolinone analogues. Ibrahim A. Al-Suwaidan, Alaa A.-M. Abdel-Aziz, Taghreed Z. Shawer, Rezk R. Ayyad, Amer M. Alanazi, Ahmad M. El-Morsy, Menshawy A. Mohamed, Naglaa I. Abdel-Aziz, Magda A.-A. El-Sayed & Adel S. El-Azab, J Enzyme Inhib Med Chem, 2016; 31(1): 78–89.
12) Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives, A. S. El-Azab, H. A. Ghabbour, W. M. El-Husseiny, A. R. Maarouf, M. A. Mohamed, A. A.-M. Abdel-Aziz, Russian Journal of General Chemistry, volme 86, issue 12, p 2837-2844 (2016).
13) Design, synthesis and evaluation of some novel 3-allyl-6-iodo-2-substituted thioquinazolinone derivatives for anticonvulsant activity, Menshawy A. Mohamed , al-azhar journal of Pharmaceutical sciences vol. 50, 2014, 178-196.
14) “ Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-,[1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties” Ahmed M. Alafeefy, Hatem A. Abdel-Aziz, Daniela Vullo, Abdul-Malek S. AlTamimi, Amani S. Awaad, Menshawy A. Mohamed, Clemente Capasso, and Claudiu T.Supuran. J. of Enzyme Inhibition and Medicinal Chemistry, volume 30,issue 1, 2015 july 15.
15) “Synthesis of Some New Quinazoline Derivatives as Potential Anti-Infective Agents” Menshawy Mohamed , Ahmed M. Alafeefy, Sami G. Abdel Hamid. Life Sci J 2014; 11(11): X-X] (ISSN: 1097-8135).
16) “ Synthesis and hypoglycemic activity of some new theophylline derivatives” Ahmed M. Alafeefy, Saleh I. Alqasoumi, Sami G. Abdel Hamid, Kamal E. H. El-tahir, Menshawy Mohamed, Mohamed E. Zain, and Amani S. Awaad. J. of Enzyme Inhibition and Medicinal Chemistry2014 Jun;29(3):443-8. .
17) “Design synthesis and biological evaluation of some novel substituted 2-mercapto-3-phenethylquinazolines as antitumor agents”. Amer M. Alanazi, Ibrahim A. Al-suwidan, Alaa A.-M. Abdel-aziz, Menshawy A. Mohamed, Ahmed M. El_morsy, Adel S. Azab. Med. Chem. Res.. (2013)22: 5566-5577.
18) “Design synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: molecular docking study”.Ibrahim A. Al-suwidan, Amer M. Alanazi, Alaa A.-M. Abdel-aziz, Menshawy A. Mohamed, Adel S. Azab. Bioorganic and Med. Chem. Lett. 23(2013) 3935-3941.
19) “Quinazoline-Tyrphostin as a new class of antitumor agents, molecular properties prediction, synthesis and biological testing”. Ahmed M.Alafeefy, Saleh I. Alqasoumi, Abdelkader . Ashour, Vijay Masand, Nabila A. Al- Jaber, Taibi Ben Hadda,, Menshawy A. Mohamed,.. Eur.J. of Med. Chem.. 53, 33 -65 (2012 ).
20) “Synthesis of some new substituted Iodoquinoline derivatives and their antimicrobial screening”. Ahmed M. Alafeefy, AdelS. Azab, Menshawy A.Mohamed, Mohamed Afroz Bakhat, and S.G. Abdel Hamide. . J.Saudi Chem. Soc.. 15, 319-325 (2011 ).
21) “ Modeling, synthesis and anticonvulsant activity of some new , quinazolinones”. Mohamed K. Ibrahim, Abd-elghany A. El-helby, Hassanin H. Hassanin, Helmy M. Sakr, Minshawy A. Menshawy, Rezk R. Ayyad, Amir A. Alfaky, Al-Azhar Journal of Pharmaceutical sciences 41, 45-65 (2010).
22) “ Modeling, synthesis and antichyperglycemic activity of novel quinazolinones containing sulphonylurea moiety”, Mohamed K. Ibrahim, Abd-elghany A. El-helby, Adel h. ghiaty, Ashraf H. Biomy, Ashraf A. Abd-el Rahman, Rezk R. Ayyad, Minshawy A. Menshawy, Ibrahim H. Eissa, Al-Azhar Journal of Biology and Pharmaceutical sciences 7, July40-50 (2009 ).
23) “ Synthesis, Molecular Modeling and anticonvulsant activity of benzoxazole derivatives”, A. A. El-helby, M. K. Ibrahim, A. A.abdelrahman, Rezk R. Ayyad, M. A. Menshawy, K. Aladel. Al-Azhar Journal of Pharmaceutical sciences 40, 252-271 (2009) .
24) “ More than a simple lipophilic contact a detailed thermodynamic analysis
of nonbasic residue in the S1- pocket of thrombin” (JMB Journal of
Molecular Biology volume 390, issue 1, 3 July 2009).

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