أعضاء هيئة التدريس | مواقع أعضاء هيئة التدريس

أ.د.عبدالملك صالح موسى التميمي

أستاذ كلية الصيدلة بالخرج

الخرج
011-588-6072
as.altamimi@psau.edu.sa

السيرة الذاتية
الأبحاث العلمية

المؤهلات العلمية

1433: دكتوراه. العلوم الصيدلانية [كيمياء صيدلانية] ، جامعة الملك سعود ، الرياض ، المملكة العربية السعودية. 1422: ماجستير. العلوم الصيدلانية [علم الأدوية] ، جامعة الملك سعود ، الرياض ، المملكة العربية السعودية. 1415: بكالوريوس. العلوم الصيدلانية ، جامعة الملك سعود ، الرياض ، المملكة العربية السعودية.

الاهتمامات البحثية

تحضير مركبات غير متجانسة و ذات فعالية دوائية

الخبرات

01-2-1443 - حتى الآن - أستاذ دكتور في الكيمياء الدوائية - جامعة الأمير سطام بن عبد العزيز
16-6-1438 - 01-2-1443 - أستاذ مشارك في الكيمياء الدوائية - جامعة الأمير سطام بن عبد العزيز
1-4-1434 - 16-6-1438 - أستاذ مساعد في الكيمياء الدوائية - جامعة الأمير سطام بن عبد العزيز

مهام ومسؤوليات

• وكيل كلية الصيدلة للدراسات العليا و البحث و الجودة منذ 24-11-1447 هـ حتى الان. • رئيس قسم الكيمياء الصيدلية بكلية الصيدلة بجامعة الأمير سطام بن عبد العزيز منذ 16-11-1437 حتى 01-07-1446 هـ. • وكيل عمادة البحث العلمي 1-6-1435حتى 30-5-1437 • رئيس قسم الكيمياء الصيدلية بكلية الصيدلة بجامعة الأمير سطام بن عبد العزيز 18-10-1434 حتى 30-5-1435هـ. • عدد كبير من المناصب الإدارية بوزارة الصحة بين 1415 و 1432.

الأبحاث العلمية

1. Riadi, Y., Matine, A., Es-Sounni, B., Bakhouch, M., Zeroual, A., Altamimi, A. S., ... & Janiski, R. (2026). Investigation of a Synergistic Corrosion Inhibitor for Mild Steel in Acidic Solutions: Theoretical and Experimental Analysis. Journal of Bio-and Tribo-Corrosion, 12(1), 30.‏
2. Afzal, O., Altharawi, A., Alqahtani, S. M., Alossaimi, M. A., Aldakhil, T., Altamimi, A. S., ... & Alamri, M. A. (2025). Anticancer potential of novel benzothiazolyl piperidine-3-carboxamide derivatives as CDKs and VEGFR2 multi-target kinase inhibitors. Journal of Computer-Aided Molecular Design, 39(1), 1-25.‏
3. El Abass, S. A., Altamimi, A. S., Aldakhil, T., El Sherbiny, D., Wahba, M. E., & Draz, M. E. (2025). BAGI‐Validated First Derivative Synchronous Fluorescence Spectroscopy for Sustainable Impurity Profiling of Meclizine: Clinical Implications for Maternal–Fetal Safety. Luminescence, 40(11), e70360.‏
4. Abdallah, N. A., Elmansi, H., Alossaimi, M. A., Altamimi, A. S., El Abass, S. A., & Elama, H. S. (2025). Harmonizing drug analysis and sustainability: Spectroscopic quantification of antiplatelet-anticoagulant regimens. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 126769.‏
5. Kumar, P., Singh, A. K., Almalki, W. H., Alruwaili, N. K., Alzahrani, A., Alhamyani, A., ... Altamimi, A. S., & Rahman, M. (2025). Development, Characterization, In Vitro, Ex Vivo, and Stability Evaluation of a Miconazole Nitrate Nanocrystal-loaded Hydrogel for Topical Application. Current Medicinal Chemistry.‏
6. Altamimi, A. S. (2025). New heterocyclic benzoxazole-pyrrolidin-2-one derivatives: Synthesis, biological assessment, DFT and docking investigations. Arabian Journal of Chemistry, 18.‏
7. Pathak, P., Almalki, W. H., Alruwaili, N. K., Alzahrani, A., Almujri, S. S., Alhamyani, A., Altamimi, A. S.,... & Rahman, M. (2025). Thymoquinone-loaded Nanosized Ethosomal-based Hydrogels: Their Preparation, Characterization, In Vitro, Ex Vivo, and Antimicrobial Evaluation against Staphylococcus aureus. Current Medicinal Chemistry, 32(22), 4585-4601.‏
8. Hussain, M. S., Altamimi, A. S. A., Afzal, M., Babu, M. A., Goyal, K., Kaur, I., ... & Balaraman, A. K. (2025). Chitosan-Based Hydrogels: Revolutionizing Corneal Wound Healing with Antibacterial and Regenerative Properties. Experimental Eye Research, 110503.‏
9. Afzal, O., Alamri, M. A., Altharawi, A., Alossaimi, M. A., Mohamed, M. A., Altamimi, A. S., & Firoz, A. Rational design, docking, simulation, synthesis, and in vitro studies of small benzothiazole molecules as selective BACE1 inhibitors. Journal of biomolecular structure & dynamics, 1-12.‏
10. Imran, M., Altamimi, A. S., Afzal, M., Babu, M. A., Goyal, K., Ballal, S., ... & Ali, H. (2025). Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach. Biogerontology, 26(1), 45.‏
11. Goyal, K., Afzal, M., Altamimi, A. S. A., Babu, M. A., Ballal, S., Kaur, I., ... & Gupta, G. (2025). Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic target. Biogerontology, 26(1), 32.‏
12. Balaraman, A. K., Altamimi, A. S. A., Babu, M. A., Goyal, K., PadmaPriya, G., Bansal, P., ... & Thangavelu, L. (2025). The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics. Biogerontology, 26(1), 46.‏
13. Bhat, A. A., Altamimi, A. S. A., Goyal, A., Goyal, K., Kaur, I., Kumar, S., ... & Gupta, G. (2025). The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology. International Immunopharmacology, 144, 113675.‏
14. Alzahrani, A. R., Mohamed, D. I., Abo Nahas, H. H., Alaa El-Din Aly El-Waseef, D., Altamimi, A. S., Youssef, I. H., ... & Saied, E. M. (2024). Trimetazidine alleviates bleomycin-induced pulmonary fibrosis by targeting the long noncoding RNA CBR3-AS1-mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis. Drug Design, Development and Therapy, 3959-3986.‏
15. Imran, M., Altamimi, A. S. A., Babu, M. A., Goyal, K., Kaur, I., Kumar, S., ... & Ali, H. (2024). Non-coding RNAs (ncRNAs) as Therapeutic Targets and Biomarkers in Oligodendroglioma. Pathology-Research and Practice, 155708.‏
16. Mohamed, M. A., Ali, A., Ali, A., Afzal, O., Ahsan, M. F., Alamri, M. A., Altamimi, A. S. A., & Ahsan, M. J. (2024). Targeting EGFR by Newer 1-(3, 5-Bis ((E)-4‑hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)-2-((substituted phenyl) amino) ethan-1-one Analogues for the Treatment of Cancer: Synthesis, In-vitro and In-silico Studies. Journal of Molecular Structure, 1315, 138826.‏
17. Kulshrestha, R., Singla, N., Afzal, O., Goyal, A., Saini, M., Altamimi, A. S. Altamimi, A. S., Ghaboura, N., Balaraman, A. K., Rajput, P., Bansal, P., Rawat, S., ... & Deb, P. K. (2024). Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment. Pathology-Research and Practice, 155657.‏
18. Altamimi, A. S. A., & Gupta, G. (2024). Role of Nutraceuticals in Treating Erectile Dysfunction via Inhibition of Phosphodiesterase-5 Enzyme: A Mini Review. Current Pharmaceutical Biotechnology, 25(15), 1905-1914.‏
19. Thangavelu, L., Altamimi, A. S., Ghaboura, N., Babu, M. A., Roopashree, R., Sharma, P., ... & Rawat, S. (2024). Targeting the p53-p21 Axis in Liver Cancer: Linking Cellular Senescence to Tumor Suppression and Progression. Pathology-Research and
20. Shaikh, M. A. J., Babu, M. A., Ghaboura, N., Altamimi, A. S., Sharma, P., Rani, R., ... & Kazmi, I. (2024). Non-Coding RNAs: Key Regulators of CDK and Wnt/β-catenin signaling in Cancer. Pathology-Research and Practice, 155659.‏
21. Salem, M. G., Alqahtani, A. M., Mali, S. N., Alshwyeh, H. A., Jawarkar, R. D., Altamimi, A. S., ... & Youssef, M. F. (2024). Synthesis and antiproliferative evaluation of novel 3, 5, 8-trisubstituted coumarins against breast cancer. Future Medicinal Chemistry, 16(11), 1053-1073.‏
22. Elshaer, S. E., Hamad, G. M., Sobhy, S. E., Darwish, A. M. G., Baghdadi, H. H., H. Abo Nahas, H., Altamimi, A. S.,.. & Saied, E. M. (2024). Supplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis. Frontiers in pharmacology, 15, 1378249.‏
23. Sahoo, A., Dwivedi, K., Almalki, W. H., Mandal, A. K., Alhamyani, A., Afzal, O., Altamimi, A. S.,..& Rahman, M. (2024). Secondary metabolites in topical infectious diseases and nanomedicine applications. Nanomedicine, 19(13), 1191-1215.‏
24. Rahman, M., Sahoo, A., Almalki, W. H., Almujri, S. S., Altamimi, A. S. A., Alhamyani, A., & Akhter, S. (2024). Peptide spiders are emerging as novel therapeutic interventions for nucleic acid delivery. Drug Discovery Today, 104021.‏
25. Hussain, M. S., Altamimi, A. S. A., Afzal, M., Almalki, W. H., Kazmi, I., Alzarea, S. I., ... & Subramaniyan, V. (2024). Kaempferol: Paving the path for advanced treatments in aging-related diseases. Experimental gerontology, 188, 112389.‏
26. Alharbi, K. S., Almalki, W. H., Alzarea, S. I., Kazmi, I., Al-Abbasi, F. A., Afzal, O., Altamimi, A. S.,..& Gupta, G. (2024). Anaesthesia-induced changes in genomic expression leading to neurodegeneration. CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders), 23(4), 411-419.‏
27. Sarma, K., Akther, M. H., Ahmad, I., Afzal, O., Altamimi, A. S., Alossaimi, M. A., ... & Gautam, P. (2024). Adjuvant novel nanocarrier-based targeted therapy for lung cancer. Molecules, 29(5), 1076.‏
28. Kazmi, I., Altamimi, A. S. A., Afzal, M., Majami, A. A., AlGhamdi, A. S., Alkinani, K.
29. catenin signaling pathway in Prostate Cancer. Pathology-Research and Practice, 254, 155134.‏
30. Shaikh, M. A. J., Altamimi, A. S. A., Afzal, M., Gupta, G., Singla, N., Gilhotra, R., ... & Dua, K. (2024). Unraveling the impact of miR-21 on apoptosis regulation in glioblastoma. Pathology-Research and Practice, 254, 155121.‏
31. Rahman, M., Afzal, O., Ullah, S. N. M. N., Alshahrani, M. Y., Alkhathami, A. G., Sahoo, A., ., Altamimi, A. S. A.,... & Beg, S. (2024). Nanocarriers for delivering nucleic acids and chemotherapeutic agents as combinational approach: Challenges, clinical progress, and unmet needs. Journal of Drug Delivery Science and Technology, 92, 105326.‏
32. Priyanka J Vyas, Shivani S Wagh, Mohan G Kalaskar, Kalpesh R Patil, Ajay Kumar Sharma, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Gaurav Gupta, Chandragouda R Patil, Volatile Oil Containing Plants as Phytopharmaceuticals to Treat Psoriasis: A Review, Current pharmaceutical biotechnology, 2024.
33. Parveen Kumar, Nishant Yadav, Benu Chaudhary, Srikant Umakanthan, Vijay Kumar Chattu, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Gaurav Gupta, Madan Mohan Gupta, Lipid Nanocapsule: A Novel Approach to Drug Delivery System Formulation Development‏, Current Pharmaceutical Biotechnology, 2024.
34. Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I Alzarea, Imran Kazmi, Fahad A Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Mohammed Albratty, Asim Najmi, Gaurav Gupta, Anaesthesia-induced changes in genomic expression leading to neurodegeneration, Journal of Alzheimer's Disease, 2023, Preprint: 1-.
35. Mahfoozur Rahman, Obaid Afzal, Shehla Nasar Mir Najib Ullah, Mohammad Y Alshahrani, Ali G Alkhathami, Abdulmalik Saleh Alfawaz Altamimi, Salem Salman Almujri, Waleed H Almalki, Eman M Shorog, Manal A Alossaimi, Ashok Kumar Mandal, Alhamyani abdulrahman, Ankit Sahoo, Nanomedicine-Based Drug-Targeting in Breast Cancer: Pharmacokinetics, Clinical Progress, and Challenges, ACS Omega, 2023.
36. Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal, Abdullah A Majami, Fahad Al Abbasi, Waleed Hassan Almalki, Sami I Alzera, Neelima Kukreti, Neeraj Kumar Fuloria, Shivkanya Fuloria, Mahendran Sekar, Abida Khan, Non-Coding RNAs: Emerging Biomarkers and Therapeutic Targets in Ulcerative Colitis, Pathology-Research and Practice, 2023 ,155037.
37. Md Sadique Hussain, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal, Imran Kazmi, Sami I Alzarea, Shakir Saleem, Parteek Prasher, Brian Oliver, Sachin Kumar Singh, Ronan MacLoughlin, Kamal Dua, Gaurav Gupta, From Carcinogenesis to Therapeutic Avenues: lncRNAs and mTOR Crosstalk in Lung Cancer, Pathology-Research and Practice, 2023, 155015.
38. Ahmad Alzamami, Eman M Radwan, Eman Abo-Elabass, Mohammed El Behery, Hussah Abdullah Alshwyeh, Ebtesam Al-Olayan, Abdulmalik Saleh Alfawaz Altamimi, Nashwah GM Attallah, Najla Altwaijry, Mariusz Jaremko, Essa M Saied, Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization, BMC chemistry, 17, 2023, 174.
39. Manal A Alossaimi, Abdulmalik Saleh Alfawaz Altamimi, Heba Elmansi, Galal Magdy, A green sustainable ultrasensitive micelle-sensitized spectrofluorimetric approach for the estimation of tafamidis in different matrices at picogram levels, Sustainable Chemistry and Pharmacy, 36,2023, 101321.
40. Sarwar Beg, Obaid Afzal, Imran Kazmi, Ali G Alkhathami, Shehla Nasar Mir Najib Ullah, Mohammad Y Alshahrani, Salem Salman Almujri, Waleed H Almalki, Abdulmalik Saleh Alfawaz Altamimi, Abdulaziz Alzahrani, Fahad A Al-Abbasi, Mahfoozur Rahman, Natural microbial surfactant containing self-nanoemulsifying formulation with improved performance of paclitaxel therapy: A newer avenue in breast cancer treatment, Journal of Drug Delivery Science and Technology, 90, 2023, 105105.
41. Manal A Alossaimi, Abdulmalik Saleh Alfawaz Altamimi, Heba Elmansi, Galal Magdy, Green synthesized nitrogen-doped carbon quantum dots for the sensitive determination of larotrectinib in biological fluids and dosage forms: Evaluation of method greenness and selectivity, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 300, 2023, 122914.
42. Mohamed Jawed Ahsan, Abuzer Ali, Amena Ali, Obaid Afzal, Mohammad Yusuf, Abdulmalik Saleh Alfawaz Altamimi, Omprakash Sharma, Manal A Alossaimi, Md Afroz Bakht, Synthesis of New 4′-(Substituted phenyl) spiro [indoline-3, 3′-[1, 2, 4] triazolidine]-2, 5′-diones as Antimicrobial, Antitubercular, and Antifungal Agents: An Insight into the ADME and Toxicity Prediction as well as in-silico Molecular Docking Studies, Journal of Molecular Structure, 1290, 2023, 135846.
43. Mushtaq Ahmad Mir, Md Habban Akhter, Obaid Afzal, Safia Obaidur Rab, Abdulmalik Saleh Alfawaz Altamimi, Manal A Alossaimi, Shehla Nasar Mir Najib Ullah, Mariusz Jaremko, Abdul-Hamid Emwas, Sarfaraz Ahmad, Nawazish Alam, Md Sajid Ali, Design-of-Experiment-Assisted Fabrication of Biodegradable Polymeric Nanoparticles: In Vitro Characterization, Biological Activity, and In Vivo Assessment ACS omega 8 (42), 38806-38821.‏
44. Vetriselvan Subramaniyan, Shivkanya Fuloria, Gaurav Gupta, Darnal Hari Kumar, Mahendran Sekar, Kathiresan Sathasivam, Kalvatala Sudhakar, Khalid Saad Alharbi, Waleed Hassan Al-Malki, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Neeraj Kumar Fuloria A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer Chemico-Biological Interactions 351 109735 2022
45. Yassine Riadi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Abuzer Ali, Amena Ali Ultrasonic-Mediated Green Synthesis of Novel S-Arylated-Pyridopyrimidines and Antimicrobial Evaluation against Escherichia coli and Staphylococcus aureus Polycyclic Aromatic Compounds 42 9 6546-6553 2022
46. Shumin Li, Zhongkai Xu, Majed Alrobaian, Obaid Afzal, Imran Kazmi, Waleed H. Almalki, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Khalid S Alharbi, Waleed M Altowayan, Tanuja Singh, Md Habban Akhter, Manish Gupta, Mahfoozur Rahman, Sarwar Beg EGF-functionalized lipid-polymer hybrid nanoparticles of 5-Fluorouracil and Sulphoraphane with enhanced bioavailability and anticancer activity against colon carcinoma Biotechnology and Applied Biochemistry 69 5 2205-2221 2022
47. Afzal Hussain, Mohammad A. Altamimi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Abuzer Ali, Amena Ali, Fleming Martinez, Mohd Usman Mohd Siddique, William E. Acree Jr., Abolghasem Jouyban Preferential Solvation Study of the Synthesized Aldose Reductase Inhibitor (SE415) in the {PEG 400 (1) + Water (2)} Cosolvent Mixture and GastroPlus-Based Prediction ACS Omega 7 1 1197–1210 2022
48. Afzal Hussain, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Abuzer Ali, Amena Ali, Fleming Martinez, Mohd Usman Mohd Siddique, William E. Acree Jr, Naushad Ali Preferential solvation study of (Z)-N-benzyl-2-{5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetamide(3) in {NMP (1) + Water (2)} co-solvent mixture and GastroPlus software based in vitro simulation Journal of Molecular Liquids 349 118491 2022
49. Md Habban Akhter, Irfan Ahmad, Mohammad Y. Alshahrani, Alhanouf I. Al-Harbi, Habibullah Khalilullah, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Shehla N.M. Najib Ullah, Abhijeet Ojha, Shahid Karim Drug Delivery Challenges and Current Progress in Nanocarrier-Based Ocular Therapeutic System Gels 8 2 82 2022
50. Abdulmalik Saleh Alfawaz Altamimi, Yassine Riadi. Microwave-Assisted Synthesis of Novel Antimicrobial N-Arylated-Pyridopyrimidines, Polycyclic Aromatic Compounds 42 6 3339-3347 2022
51. Mir Mohammad Shahroz, Hemant Kumar Sharma, Abdulmalik Saleh Alfawaz Altamimi, Mubarak A. Alamri, Abuzer Ali, Amena Ali, Safar Alqahtani, Ali Altharawi, Alhumaidi B. Alabbas, Manal A. Alossaimi, Yassine Riadi, Ahmad Firoz, Obaid Afzal* Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study Molecules 27 4 1159 2022
52. Mohammad Islamuddin, Abuzer Ali, Obaid Afzal, Amena Ali, Intzar Ali, Abdulmalik Saleh Alfawaz Altamimi, Mubarak A. Alamri, Kentaro Kato, and Shama Parveen Thymoquinone Induced Leishmanicidal Effect via Programmed Cell Death in Leishmania donovani ACS Omega 7 12 10718-10728 2022
53. Khalid Saad Alharbi, Yogendra Singh, Waleed Hassan Almalki, Sushama Rawat, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Sachin Kumar Singh, Shvetank Bhatt, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora Chemico-Biological Interactions 358 109898 2022
54. Shahid Karim, Md Habban Akhter, Abdulhadi S. Burzangi, Huda Alkreathy, Basma Alharthy, Sabna Kotta, Shadab Md, Md Abdur Rashid, Obaid Afzal, Abdulmalik S. A. Altamimi, Habibullah Khalilullah Phytosterol-Loaded Surface-Tailored Bioactive-Polymer Nanoparticles for Cancer Treatment: Optimization, In Vitro Cell Viability, Antioxidant Activity, and Stability Studies Gels 8 4 219 2022
55. Kumar Venkatesan, Nazima Haider, Mohammad Yusuf, Afzal Hussain, Obaid Afzal, Sabina Yasmin, Abdulmalik S.A. Altamimi Water/transcutol/lecithin/M− 812 green cationic nanoemulsion to treat oxytetracycline contaminated aqueous bulk solution Journal of Molecular Liquids 357 119154 2022
56. Mohammad Arshad Javed Shaikh, Khalid Saad Alharbi, Waleed Hassan Almalki, Syed Sarim Imam, Mohammed Albratty, Abdulkarim M. Meraya, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Yogendra Singh, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta Sodium alginate based drug delivery in management of breast cancer Carbohydrate Polymers 292 119689 2022
57. Mayank Handa, Waleed H. Almalki, Rahul Shukla, Obaid Afzal, AbdulMalik Saleh Alfawaz Altamimi, Sarwar Beg, Mahfoozur Rahman Active pharmaceutical ingredients (APIs) in ionic liquids: an effective approach for API physiochemical parameter optimization Drug Discovery Today 27 9 2415-2424 2022
58. Alossaimi M.A., Altamimi A.S.A., Alqahtani S.M., Hassan M.Z., Rashid M., Kamal M., Afzal O HPLC Method Development and Validation for the Estimation of Thymoquinone in Nigella sativa Seed Extract by Quality by Design (QbD) Approach Latin American Journal of Pharmacy 41 6 1110-1118 2022
59. S.M. Kawish, Shwetakshi Sharma, Waleed H Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Sarwar Beg and Farhan J Ahmad Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes. Current Drug Metabolism 23 8 616 - 629 2022
60. Suman Rohilla, Mahaveer Singh, Sami I. Alzarea, Waleed Hassan Al-Malki, Fahad A. Al-Abbasi, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta Recent developments and challenges in the molecular targeted therapies of non-small cell lung cancer Journal of Environmental Pathology, Toxicology and Oncology 42 1 27-50 2022
61. Obaid Afzal, Hisham Abdulaziz Alshammari, Mohammad A. Altamimi, Afzal Hussain, Basmah Almohaywi, Abdulmalik S.A. Altamimi Hansen solubility parameters and green nanocarrier based removal of trimethoprim from contaminated aqueous solution Journal of Molecular Liquids 361 119657 2022
62. Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta A narrative review on the biology of piezo1 with platelet-rich plasma in cardiac cell regeneration Chemico-Biological Interactions 363 110011 2022
63. Aljurbui S.J., Hussain A., Yusuf M., Ramzan M., Afzal O., Almohaywi B., Yasmin S., Altamimi A.S.A. Impact of Composition and Morphology of Ketoconazole-Loaded Solid Lipid Nanoparticles on Intestinal Permeation and Gastroplus-Based Prediction Studies ACS Omega 7 26 22406–22420 2022
64. Khalid Saad Alharbi, Tabinda Ali, Yogendra Singh, Ahmed Saleh Ali Al-Ghamdi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta Biochemical interaction of pyrvinium in gentamicin-induced acute kidney injury by modulating calcium dyshomeostasis and mitochondrial dysfunction Chemico-Biological Interactions 363 110020 2022
65. Madhu Gupta, Vikas Sharma, Kalicharan Sharma, Anoop Kumar, Ajay Sharma, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Gaurav Gupta, Keshav Raj Paudel, Philip M. Hansbro, Kamal Dua A kNGR Peptide-Tethered Lipid–Polymer Hybrid Nanocarrier-Based Synergistic Approach for Effective Tumor Therapy: Development, Characterization, Ex-Vivo, and In-Vivo Assessment Pharmaceutics 14 7 1401 2022
66. Sarwar Beg, Mayank Handa, Rahul Shukla, Mahfoozur Rahman, Waleed H. Almalki, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi Wearable smart devices in cancer diagnosis and remote clinical trial monitoring: transforming the healthcare applications Drug Discovery Today 27 10 103314 2022
67. Khalid Saad Alharbi, Navneet Joshi, Yogendra Singh, Waleed Hassan almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Gaurav Gupta Molecular exploration of hidden pleiotropic activities of azoles on dermatophytes in human tinea corporis infection Journal of Medical Mycology 32 4 101311 2022
68. Beg M.A., Shivangi, Afzal O., Akhtar M.S., Altamimi A.S.A., Hussain A., Imam M.A., Ahmad M.N., Chopra S., Athar F. Potential Efficacy of β-Amyrin Targeting Mycobacterial Universal Stress Protein by In Vitro and In Silico Approach Molecules 27 14 4581 2022
69. Shaharyar M.A., Bhowmik R., Afzal O., Altamimi A.S.A., Alzarea S.I., Almalki W.H., Ali S.Z., Mandal P., Mandal A., Ayoob M., Kazmi I., Karmakar S. Anti-Hypertensive Activity of Some Selected Unani Formulations: An Evidence-Based Approach for Verification of Traditional Unani Claims Using LC-MS/MS for the Evaluation of Clinically Relevant Blood Parameters in Laboratory Rats Journal of Clinical Medicine 11 15 4628 2022
70. Obaid Afzal, Md Habban Akhter, Irfan Ahmad, Khursheed Muzammil, Adam Dawria, Mohammad Zeyaullah, Abdulmalik SA Altamimi, Habibullah Khalilullah, Shehla Nasar Mir Najib Ullah, Mohammad Akhlaquer Rahman, Abuzer Ali, Naiyer Shahzad, Mariusz Jaremko, Abdul-Hamid Emwas, Ibrahim Abdel Aziz Ibrahim A β–Sitosterol Encapsulated Biocompatible Alginate/Chitosan Polymer Nanocomposite for the Treatment of Breast Cancer Pharmaceutics 14 8 1711 2022
71. Khalid Saad Alharbi, Mohammad Arshad Javed Shaikh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy Chemico-Biological Interactions 366 110108 2022
72. Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M Balaramnavar, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Gaurav Gupta, Madan Mohan Gupta Anti-Cancer Phytochemical-Based Nano-Formulations: Therapeutic Intervention in Cancer Cell Lines Journal of Environmental Pathology, Toxicology and Oncology 42 1 79-93 2022
73. Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.) Metabolites 12 9 854 2022
74. Khalid Saad Alharbi, Yogendra Singh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Dinesh Kumar Chellappan, Sachin Kumar Singh, Kamal Dua & Gaurav Gupta Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders Molecular Biology Reports 49 11 11101–11111 2022
75. Khalid Saad Alharbi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik S. A. Altamimi, Waleed Hassan Almalki, Muhammad Shahid Nadeem, Muhammad Afzal, Nadeem Sayyed, Imran Kazmi Effects of the Anthocyanin Hirsutidin on Gastric Ulcers: Improved Healing through Antioxidant Mechanisms Journal of Natural Products 85 10 2406–2412 2022
76. Mohamed Jawed Ahsan, Amena Ali, Abuzer Ali, Arunkumar Thiriveedhi, Mohammed A. Bakht, Mohammad Yusuf, Salahuddin, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders ACS Omega 7 43 38207–38245 2022
77. Obaid Afzal, Mohammad Yusuf, Mohamed Jawed Ahsan, Abdulmalik Saleh Alfawaz Altamimi, Md. Afroz Bakht, Amena Ali, Salahuddin Chemical Modification of Curcumin into Its Semi-Synthetic Analogs Bearing Pyrimidinone Moiety as Anticancer Agents Plants 11 20 2737 2022
78. Obaid Afzal, Abdulmalik S. A. Altamimi, Bismillah Mubeen, Sami I. Alzarea, Waleed Hassan Almalki, Salwa D. Al-Qahtani, Eman M. Atiya, Fahad A. Al-Abbasi, Fatima Ali, Inam Ullah, Muhammad Shahid Nadeem, Imran Kazmi mTOR as a Potential Target for the Treatment of Microbial Infections, Inflammatory Bowel Diseases, and Colorectal Cancer International Journal of Molecular Science 23 20 12470 2022
79. Khalid Saad Alharbi, Mohammad Arshad Javed Shaikh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, M Ravindra Babu, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta Oligonucleotides: A novel area of interest for drug delivery in neurodegenerative diseases Journal of Drug Delivery Science and Technology 77 103849 2022
80. Huan Li, Jian Li, Juanli Wang, Obaid Afzal, Abdulmalik SA Altamimi, Shehla Nasar Mir Najib Ullah, Sireen Abdul Rahim Shilbayeh, Alnada Abdalla Ibrahim, Shahanavaj Khan Analysis of Anti-Arrhythmic Impacts of Crocin through Estimation of Expression of Cx43 in Myocardial Infarction Using a Rat Animal Model ACS Omega 7 42 37164–37169 2022
81. Pankaj Kumar, Bharti Mangla, Sarwar Beg, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed H. Almalki, Shehla Nasar Mir Najib Ullah, Geeta Aggarwal Optimization and validation of stability indicating RP-HPLC method for the quantification of gefitinib in bulk drug and nanoformulations: An application towards in vitro and ex vivo performance evaluation Arabian Journal of Chemistry 15 12 104333 2022
82. Asma B. Omer, Mahmood Hassan Dalhat, Mohammad Kaleem Khan, Obaid Afzal, Abdulmalik S. A. Altamimi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi Butin Mitigates Memory Impairment in Streptozotocin-Induced Diabetic Rats by Inhibiting Oxidative Stress and Inflammatory Responses Metabolites 12 11 1050 2022
83. Obaid Afzal, Mahmood Hassan Dalhat, Abdulmalik S. A. Altamimi, Rabia Rasool, Sami I. Alzarea, Waleed Hassan Almalki, Bibi Nazia Murtaza, Saima Iftikhar, Shamaila Nadeem, Muhammad Shahid Nadeem, Imran Kazmi Green tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits Molecules 27 21 7604 2022
84. Mahfoozur Rahman, Waleed H. Almalki, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Shehla Nasar Mir Najib Ullah, Md. Abul Barkat, Sarwar Beg Chiral-engineered supraparticles: Emerging tools for drug delivery Drug Discovery Today 28 1 103420 2023
85. Barkat A., Rahman M., Alharbi K.S., Altowayan W.M., Alrobaian M., Afzal O., Altamimi A.S.A., Alhodieb F.S., Almalki W.H., Choudhry H., Singh T., Beg S. Biocompatible Polymeric Nanoparticles for Effective Codelivery of Tamoxifen with Ganoderic Acid A: Systematic Approach for Improved Breast Cancer Therapeutics Journal of Cluster Science 2022
86. Md Sayeed Akhtar, Md Quamrul Hassan, Obaid Afzal, Abdulmalik S A Altamimi, Mohd Zaheen Hassan, Arun Kumar, Asif Ansari Shaik Mohammad, Fauzia Tabassum Comparative efficacy of levosimendan, ramipril, and sacubitril/valsartan in isoproterenol induced experimental heart failure: a hemodynamic and molecular approach. Current Molecular Pharmacology 2022
87. Khalid Saad Alharbi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Hafiz A. Makeen, Mohammed Albratty Potential role of nutraceuticals via targeting a Wnt/β-catenin and NF-κB pathway in treatment of osteoarthritis. Journal of Food Biochemistry e14427 2022
88. Mahfoozur Rahman, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Majed Alrobaian, Md. Abul Barkat, Shehla Nasar Mir Najib Ullah, Waleed H. Almalki, Tanuja Singh, Sarwar Beg, Hani Choudhry Paclitaxel and Curcumin as Dual-Drug-Loaded Lipid Nanocapsules in the Management of Brain Tumour Journal of Cluster Science 2022
89. Md Sayeed Akhtar, Md Quamrul Hassan, Aisha Siddiqui, Sirajudeen S Alavudeen, Obaid Afzal, Abdulmalik SA Altamimi, Syed Obaidur Rahman, Mallika Khurana, Mohamed Jawed Ahsan, Arun Kumar, Fauzia Tabassum Levosimendan: mechanistic insight and its diverse future aspects in cardiac care Acta Cardiologica 2022
90. Benu Chaudhary, Deepak Singla, Preeti Arya, Abhishek Dabra, Parveen Kumar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Gaurav Gupta, Madan Mohan Gupta Versatile Imidazole Synthesis Via Multicomponent Reaction Approach Journal of Heterocyclic Chemistry 2022
91. Khalid Saad Alharbi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Hafiz A. Makeen, Mohammed Albratty A study of the molecular mechanism of quercetin and dasatinib combination as senolytic in alleviating age-related and kidney diseases Journal of Food Biochemistry e14471 2022
92. Afzal Hussain, Obaid Afzal, Mohammad A Altamimi, Abdulmalik Saleh Alfawaz Altamimi, Mohhammad Ramzan, Mohd Zaheen Hassan, Wael A Mahdi, Thomas J Webster Improved Subcutaneous Delivery of Ketoconazole Using EpiDerm and HSPiP Software-Based Simulations as Assessed by Cell Viability, Cellular Uptake, Permeation, and Hemolysis In Vitro Studies ACS Omega 2022
93. Rajeshwar Kamal Kant Arya, Juyal Vijay, Dheeraj Bisht, Mohammad Rashid, Abdulmalik Saleh Alfawaz Altamimi, Obaid Afzal, Neeraj Kumar Sethiya Enhanced Brain Delivery via Intranasal Administration of Carbamazepine Loaded Solid Lipid Nanoparticles: Optimization, Pharmacokinetic analysis, In-vitro and In-vivo Drug Release Study. Current Drug Delivery 2022Lihua Chen, Majed Alrobaian, Obaid Afzal, Imran Kazmi, Sunil K. Panda, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Waleed H. Almalki, Hanadi A. Katouah, Tanuja Singh, Kriti Soni, Abdul Hafeez, Sarwar Beg, Vikas Kumar, Mahfoozur Rahman
Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro, in vivo evaluation, and dermatokinetic studies, Drug Delivery, 28, 2021, 1972-1981.
94. A Hussain, S Alshehri, M Ramzan, O Afzal, ASA Altamimi, MA Alossaimi‏
Biocompatible solvent selection based on thermodynamic and computational solubility models, in-silico GastroPlus prediction, and cellular studies of ketoconazole for Journal of Drug Delivery Science and Technology 65, 2021, 102699‏.
95. Yassine Riadi, Obaid Afzal, Abdul-Malek S Al-Tamimi, Abuzer Ali, Amena Ali Ultrasonic-Mediated Green Synthesis of Novel S-Arylated-Pyridopyrimidines and Antimicrobial Evaluation against Escherichia coli and Staphylococcus aureus, Polycyclic Aromatic Compounds, 1-8.
96. Mohammad Islamuddin, Obaid Afzal, Wajihul Hasan Khan, Malik Hisamuddin, Abdulmalik Saleh Alfawaz Altamimi, Ibraheem Husain, Kentaro Kato, Mubarak A.
Alamri, Shama Parveen
Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-methyl-3-(3-morpholinopropanoyl) quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins, ACS Omega, 6, 2021, 9791-9803.
97. Afzal Hussain, Sultan Alshehri, Mohd Ramzan, Obaid Afzal, Abdulmalik S. A. Altamimi, Manal A. Alossaimi
Biocompatible solvent selection based on thermodynamic and computational solubility models, in-silico GastroPlus prediction, and cellular studies of ketoconazole for subcutaneous delivery, Journal of Drug Delivery Science and Technology, 2021, 102699.
98. Bin Wang, Lin Sun, Mingyun Wen, Youchun Tan, Waleed H Almalki, Hanadi Katouah, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Majed Alrobaian, Khalid S Alharbi, Sattam K Alenezi, Adel F Alghaith, Sarwar Beg, Mahfoozur Rahman,
Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma‏
Saudi Pharmaceutical Journal 29 (8), 843-856‏
99. Yang Gao, Waleed H Almalki, Obaid Afzal, Sunil K Panda, Imran Kazmi, Majed Alrobaian, Hanadi A Katouah, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Sultan Alshehri, Kriti Soni, Ibrahim Abdel Aziz Ibrahim, Mahfoozur Rahman, Sarwar Beg
Systematic development of lectin conjugated microspheres for nose-to-brain delivery of rivastigmine for the treatment of Alzheimer’s disease‏, Biomedicine & Pharmacotherapy 141, 2021, 111829‏.
100. A Hussain, O Afzal, ASA Altamimi, R Ali‏,
Application of green nanoemulsion to treat contaminated water (bulk aqueous solution) with azithromycin,‏ Environmental Science and Pollution Research, 2021, 1-11‏
101. Mohammad Khalid, Mohammed H Alqarni, Ambreen Shoaib, Muhammad Arif, Ahmed I Foudah, Obaid Afzal, Abuzer Ali, Amena Ali, Saad S Alqahtani, Abdulmalik SA Altamimi,
Anti-Arthritic and Anti-Inflammatory Potential of Spondias mangifera Extract Fractions: An In Silico, In Vitro and In Vivo Approach‏, Plants 10 (5), 2021, 825‏.
102. M Rashid, O Afzal, ASA Altamimi‏,
BENZIMIDAZOLE MOLECULE HYBRID WITH OXADIAZOLE RING AS ANTIPROLIFERATIVE AGENTS: IN-SILICO ANALYSIS, SYNTHESIS AND BIOLOGICAL EVALUATION‏, Journal of the Chilean Chemical Society 66 (2), 2021, 5164-5182‏.
103. Sarwar Beg, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Waleed H Almalki, Saad Alghamdi, Majed Alrobaian, Khalid S Alharbi, Mohammed S Alshammari, Sunil K Panda, Ibrahim Abdel Aziz Ibrahim, Tanuja Singh, Mahfoozur Rahman, Implications of phospholipid-based nanomixed micelles of olmesartan medoxomil with enhanced lymphatic drug targeting ability and systemic bioavailability‏, Journal of Drug Delivery Science and Technology 62, 2021, 102273‏
104. Oussama ouerghi, Mohammed H. Geesi, Abdellah Kaibaa, El Hassane Anouar, Abdul-Malek S. Al-Tamimi, Philippe Guionneaud, Elmutasim O Ibnouf, Rachid Azzallou, Md Afroz Bakht, Yassine Riadi
Synthesis, antibacterial evaluation, crystal structure and molecular interactions analysis of new 6-Bromo-2–chloro–3-butylquinazolin-4(3H)-one, Journal of Molecular Structure, 1225, 2021, 129166.
105. Abdul-Malek S. Al-Tamimi, Yassine Riadi
Microwave-Assisted Synthesis of Novel Antimicrobial N-Arylated-Pyridopyrimidines, Polycyclic Aromatic Compounds, 2020, 1-9.
106. Abdulmalik Saleh Alfawaz Altamimi, Sandhya Bawa, Fareeda Athar, Md Quamrul Hassan, Yassine Riadi, Obaid Afzal
Pyrrolidin-2-one linked benzofused heterocycles as novel small molecule monoacylglycerol lipase inhibitors and antinociceptive agents, Chem Biol Drug Des. 2020, 00:1–15.
107. Andrea Angelia, Thomas S. Peat, Silvia Selleri, Abdulmalik Saleh Alfawaz Altamimi, Claudiu T. Supurana, Fabrizio Cartaa,
X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX, Bioorganic Chemistry, 2020, 97, 103669.
108. GAMAL A. SOLIMAN, SHERIF A. ABDEL-GAWAD, MOHD N. ANSARI, ABDUL-MALEK S. ALTAMIMI, HOSSNY A. EL-BANNA, HISHAM Y. ELZORBA, NOHA F. HASSAN, The Potential Cardioprotective Effect Of Matricaria Chamomilla Extract Against Diabetes-Induced Oxidative Stress In Rats, FARMACIA, 2020, 68, 269-279.
109. Abdul-Malek S. Al-Tamimi, Mikel Etxebeste-Mitxeltoren, Carmen Sanmartin, Antonio Jimenez-Ruiz, Leo Syrjanen, Seppo Parkkila, Silvia Selleri, Fabrizio Carta, Discovery of new organoselenium compounds as antileishmanial agents, Bioorganic Chemistry, 2019, 86, 339–345.
110. Claudiu T. Supuran, Abdulmalik Saleh Alfawaz Altamimi & Fabrizio Carta,
Carbonic anhydrase inhibition and the management of glaucoma: a literature and patent review 2013-2019. Expert Opinion on Therapeutic Patents, 2019, 29, 781-792.
111. Murat Bozdag, Abdulmalik Saleh Alfawaz Altamimi, Daniela Vullo, Claudiu T. Supuran, Fabrizio Carta,
State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes, Current Medicinal Chemistry, 2019, 26, 2558 – 2573.
112. Murat Bozdag, Marta Ferraroni, Carol Ward, Fabrizio Carta, Silvia Bua, Andrea Angeli, Simon P. Langdon, Ian H. Kunkler, Abdul-Malek S. Al-Tamimi, Claudiu T. Supuran.
Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast, European Journal of Medicinal Chemistry 2019, 182, 111600.
113. Y. Kalisha Vali, Rambabu Gundla, Om V. Singh, Yasinalli Tamboli, Lorenzo Di Cesare Manelli, Carla Ghelardini, Abdul-Malek S. Al-Tamimi, Fabrizio Carta, Andrea Angelie, Claudiu T. Supurane,
Spirocyclic sulfonamides with carbonic anhydrase inhibitory and antineuropathic pain activity, Bioorganic Chemistry, 2019, 92, 103210.
114. Lamya H. Al-Wahaibi, Nandakumar Santhosh Kumar, Ali A. El-Emam, Natarajan S. Venkataramanan, Hazem A. Ghabbour, Abdul-Malek S. Al-Tamimi,
Investigation of potential anti-malarial lead candidate 2-(4- fluorobenzylthio)-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole: Insights from crystal structure, DFT, QTAIM and hybrid QM/MMbinding energy analysis, Journal of Molecular Structure 1175, 2019, 230-240.
115. Mohamed Jawed Ahsan, Rupesh Kumar Kumawat, Surender Singh Jadav, Mohammed H. Geesi, Mohammed Afroz Bakht, Mohd. Zaheen Hassan, Abdulmalik Bin Saleh Al-Tamimi, Yassine Riadi , Salahuddin, Afzal Hussainc, Narayan Murthy Ganta, Habibullah Khalilullah Mohamed, H. K.
Synthesis, Cytotoxic Evaluation, and Molecular Docking Studies of N-(7- Hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)acetamide/benzamide Analogues. Lett. Drug Des. Discov. 2019,16, online, doi:10.2174/1570180815666180501160047.
116. Lamya H. Al-Wahaibi, NuriÖztürk, Hanan M. Hassan, Yusuf Sertd, Ali A. El- Emam, Abdul-Malek S. Al-Tamimi, Halil Gökce, Experimental (FT-IR, Laser-Raman and NMR) and theoretical comparative study on 2-benzylsulfanyl-4-pentyl-6-(phenylsulfanyl)pyrimidine-5-carbonitrile, a potential bioactive agent, Journal of Theoretical and Computational Chemistry, 17, 2018, 1850035.
117. Dehbi, O.; Ishak, E. A.; Bakht, M. A.; Geesi, M. H.; Alshammari, M. B.; Chagnault, V.; Kaiba, A.; Lazar, S.; Altamimi A. M. S.; Riadi, Y, Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation. Green Chem. Lett. Rev. 2018, 11, 62 (Corrigendum) GREEN CHEMISTRY LETTERS AND REVIEWS, 2018, 11, NO. 2, 165.
118. Abdul-Malek S. Al-Tamimi , Y. Sheena Mary, Pankaj B. Miniyar, Lamya H. Al-Wahaibi, Ali A. El-Emam, Stevan Armakovi, Sanja J. Armakovi
Synthesis, spectroscopic analyses, chemical reactivity and molecular docking study and anti-tubercular activity of pyrazine and condensed oxadiazole derivatives, Journal of Molecular Structure, 1225, 2021, 129166.
119. Ozlem Akgul, Lorenzo Di Cesare Mannelli, Daniela Vullo, Andrea Angeli, Carla Ghelardini, Gianluca Bartolucci, Abdulmalik Saleh Alfawaz Altamimi, Andrea Scozzafava, Claudiu T. Supuran, and Fabrizio Carta,
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs−CAIs) for the Management of Rheumatoid Arthritis J. Med. Chem. 2018, 61, 4961−4977.
120. Ahsan, M. J.; Choupra, A.; Sharma, R. K.; Jadav, S. S.; Padmaja, P.; Hassan, M.; Al-Tamimi, A.; Geesi, M. H.; Bakht, M. A. Rationale Design, Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of 1, 3, 4-oxadiazole Analogues. Anti-Cancer Agents Med. Chem. (Formerly Curr. Med. Chem. Agents) 2018, 18, 121–138, doi:10.2174/1871520617666170419124702.
121. M. J. Ahsan, R. P. Yadav, S. Saini, Mohd. Z. Hassan, M. A. Bakht, S. S. Jadav, A. B. S. Al-Tamimi, M. H. Geesi, Md Y.Ansari, H. Khalilullah, Y. Riadi, Synthesis, Cytotoxic Evaluation, and Molecular Docking Studies of New Oxadiazole Analogues, Lett. Org. Chem. 2018, 15, 49–56.
122. Abdul-Malek S. Al-Tamimi, Y. Sheena Mary, Hanan M. Hassan c, K.S. Resmi , Ali A. El-Emam d, B. Narayana, B.K. Sarojini, Study on the structure, vibrational analysis and molecular docking of fluorophenyl derivatives using FT-IR and density functional theory computations, Journal of Molecular Structure, 2018, 1164, 172-179.
123. Abdul-Malek S. Altamimi, Ahmed M. Alafeefy, Agnese Balode, Igor Vozny, Aleksandrs Pustenko, Mohey Eldin El Shikh, Fatmah A. S. Alasmary, Sherif A. Abdel-Gawad & Raivis Žalubovskis, Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A., Journal of Enzyme Inhibition and Medicinal Chemistry, 33:1, 147-150
124. Murat Bozdag, Ahmed Mahmoud Alafeefy, Abdul Malik Altamimi, Fabrizio Carta, Claudiu T. Supuran, Daniela Vullo., Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 25 (2017) 2782–2788.
125. Murat Bozdag, Ahmed Mahmoud Alafeefy, Abdul Malik Altamimi, Daniela Vullo, Fabrizio Carta,Claudiu T. Supuran., Coumarins and other fused bicyclic heterocycles with selective tumorassociated carbonic anhydrase isoforms inhibitory activity, Bioorganic and Medicinal Chemistry, 25,(2), 2017, 677-683.
126. Abdul-Malek S. Al-Tamimi, Electronic structure, hydrogen bonding and spectroscopic profile of a new 1,2,4-triazole-5(4H)-thione derivative: A combined experimental and theoretical (DFT) analysis, Journal of Molecular Structure 1120 (2016) 215-227.
127. Murat Bozdag , Ahmed M. Alafeefy , Fabrizio Carta , Mariangela Ceruso , Abdul-Malek S. Al-Tamimi ,Abdulla A. Al-Kahtani , Fatmah A. S. Alasmary , Claudiu T. Supuran , Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties, Bioorganic & Medicinal Chemistry 24 (2016) 4100–4107.
128. Ahmed M. Alafeefy , Fabrizio Carta , Mariangela Ceruso , Abdul-Malek S. Al-Tamimi ,Abdulla A. Al-Kahtani , Claudiu T. Supuran,
Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma, Bioorganic & Medicinal Chemistry 24 (2016) 1402–1407.
129. Monirah A. Al-Alshaikh, Hazem A. Ghabbour, Abdul-Malek S. Al-Tamimi, Mohammed S.M. Abdelbaky, Santiago Garcia-Granda and Ali A. El-Emam, Crystal structure of 5-(adamantan-1-yl)-3-[(4-chloroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione, C19H22ClN3OS, Z. Kristallogr. NCS 2016;v 231, p301-303.
130. Ahmed M. Alafeefy , Rehan Ahmad , Maha Abdulla , Wagdy M. Eldehna ,Abdul-Malek S. Al-Tamimi , Hatem A. Abdel-Aziz , Omar Al-Obaid , Fabrizio Carta ,Abdulla A. Al-Kahtani , Claudiu T. Supuran ,
Development of certain new 2-substituted-quinazolin-4-ylaminobenzenesulfonamide as potential antitumor agents, European Journal of Medicinal Chemistry 109 (2016) 247e253.
131. Ebtehal S. Al-Abdullah, Hazem A. Ghabbour, Hamad M. Alkahtani, Abdul-Malek S. Al-Tamimi and Ali A. El-Emam,
Crystal structure of N-(adamantan-1-yl)-4-phenylpiperazine-1-carbothioamide, C21H29N3S, Z. Kristallogr. NCS 2016; aop.
132. Haya I. Aljohar, Hazem A. Ghabbour, Abdul-Malek S. Al-Tamimi, Haitham AlRabiah and Ali A. El-Emam,
Crystal structure of 4-[(E)-(2-chloro-6-fluorobenzylidene)amino] -1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one, C18H15ClFN3O, Z. Kristallogr. NCS 2016; aop.
133. Abdul-Malek S. Al-Tamimi, Hazem A. Ghabbour and Ali A. El-Emam,
Crystal structure of N'-(adamantan-2-ylidene)pyridine-3-carbohydrazide, C16H19N3O, Z. Kristallogr. NCS 2016; 231(2): 573–575.
134. Abdul-Malek S. Al-Tamimi, Hazem A. Ghabbour and Ali A. El-Emam,
Crystal structure of 6-oxo-4-propyl-2-(propylthio)-1,6-dihydropyrimidine-5-carbonitrile, C11H15N3OS, Z. Kristallogr. NCS 2016; 231(2): 583–585.
135. Murat Bozdag , Ahmed M. Alafeefy , Daniela Vullo , Fabrizio Carta , Nurcan Dedeoglu ,Abdul-Malek S. Al-Tamimi , Nabila A. Al-Jaber , Andrea Scozzafava , Claudiu T. Supuran ,
Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity, Bioorganic & Medicinal Chemistry 23 (2015) 7751–7764.
136. Alafeefy AM, Ceruso, M, Al-Tamimi AM, Del Prete S, Supuran CT, Capasso C. Inhibition studies of quinazoline-sulfonamide derivatives against the gamma-CA (PgiCA) from the pathogenic bacterium, Porphyromonas gingivalis. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. AUG 2015; 30(4): 592-596.
137. Alafeefy AM, Abdel-Aziz HA, Vullo D, Al-Tamimi AM, Awaad AS, Mohamed MA, Capasso C, Supuran CT. Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. FEB 2015; 30(1): 52-56.
138. Sebastian SSHR, Al-Tamimi AM, El-Brollosy NR, El-Emam AA, Panicker, CY, Van Alsenoy C. Vibrational spectroscopic (FT-IR and FT-Raman) studies, HOMO-LUMO, NBO analysis and MEP of 6-methyl-1-({[(2E)-2-methyl-3-phenyl-prop-2-en-l-yl]oxy}methyl)-1,2,3,4-tetra-hydroquinazoline-2,4-dione, a potential chemotherapeutic agent, using density functional methods. SPECTROCHIMICA ACTA PART A. JAN 5 2015; 134: 316-325.
139. Mary YS, Al-Tamimi AM, El-Brollosy NR, El-Emam AA, Jojo PJ, Panicker CY, Van Alsenoy C. Molecular structure and vibrational spectra of 2-Ethoxymethyl-6-ethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione, a potential chemotherapeutic agent, by density functional methods. SPECTROCHIMICA ACTA PART A. DEC 10 2014; 133: 439-448.
140. Alafeefy AM, Ceruso M, Al-Tamimi AM, Del Prete S, Capasso C, Supuran CT. Quinazoline-sulfonamides with potent inhibitory activity against the alpha-carbonic anhydrase from Vibrio cholera. BIOORGANIC & MEDICINAL CHEMISTRY. OCT 1 2014; 22: 5133-5140.
141. Sert Y, El-Emam AA, Al-Abdullah ES, Al-Tamimi AM, Cirak C, Ucun F. Use of vibrational spectroscopy to study 4-benzyl-3-(thiophen-2-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thione: A combined theoretical and experimental approach. SPECTROCHIMICA ACTA PART A. MAY 21 2014; 126: 280-290.
142. Al-Tamimi AM, El-Emam AA, Al-Deeb OA, Prasad O, Pathak SK, Srivastava R, Sinha L. Structural and spectroscopic characterization of a novel potential anti-inflammatory agent 3-(adamantan-1-yl)-4-ethyl-1H-1,2,4-triazole-5(4H)thione by first principle calculations. SPECTROCHIMICA ACTA PART A. APR 24 2014; 124: 108-123.
143. Alafeefy AM, Abdel-Aziz HA, Vullo D, Al-Tamimi AM, Al-Jaber NA, Capasso C, Supuran CT. Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfuri hydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl-or2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties. Bioorganic Med Chem. 2014 Jan 1; 22(1):141-7.
144. Abdul-Malek S. Al-Tamimi, Ahmed M. Alafeefy, Ali A. El-Emam, Seik Weng Ng and Edward R. T. Tiekink. 5-(Adamantan-1-yl)-N-methyl-1,3,4-thiadiazol-2-amine. Acta Crystallographica Section E. Online April 2013.
145. El-Emam AA, Al-Tamimi AM, Al-Omar MA, Alrashood KA, Habib EE. Synthesis and antimicrobial activity of novel 5-(1-adamantyl)-2-aminomethyl-4-substituted-1,2,4-triazoline-3-thiones. Eur J Med Chem. 2013;68C:96-102.
146. Abdul-Malek S. Al-Tamimi, Ebtehal S. Al-Abdullah, Ali A. El-Emam, Seik Weng Ng and Edward R. T. Tiekink. 3-(Adamantan-1-yl)-4-[(E)-(2,6-difluorobenzylidene) amino]-1-[(4-ethylpiperazin-1-yl)methyl]-4,5—dihydro-1H-1,2,4-triazole-5-thione. Acta Crystallographica Section E. Online April 2013.
147. Abdul-Malek S. Al-Tamimi, Ahmed M. Alafeefy, Ali A. El-Emam, Seik Weng Ng and Edward R. T. Tiekink. 5-(Adamantan-1-yl)-3-[(4-fluoroanilino)methyl]-2,3—dihydro-1,3,4-oxadiazole-2-thione. Acta Crystallographica. E69, o730, Online April 2013.
148. Abdul-Malek S. Al-Tamimi, Omar A. Al-Deeb, Ali A. El-Emam, Seik Weng Ng and Edward R. T. Tiekink. 5-(Adamantan-1-yl)-3-anilinomethyl]-2,3—dihydro-1,3,4-oxadiazole-2-thione. Acta Crystallographica. E69, o729, Online April 2013.
149. Ali A. El-Emam, Abdul-Malek S. Al-Tamimi, Khalid A.Alrashood, Seik Weng Ng . and Edward R. T. Tiekink. 3-(Adamantan-1-yl)-4-methyl-1-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}-methyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione. Acta Crystallographica ,E69, o695–o696, Online April 2013.
150. Abdul-Malek S. Al-Tamimi, Ebtehal S. Al-Abdullah,Ali A. El-Emam, Seik Weng Ng and Edward R. T.Tiekink, 3-(Adamantan-1-yl)-4-[(E)-(2,6-difluorobenzylidene)amino]-1-[(4-ethylpiperazin-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione, Acta Crystallographica , E69, o685–o686, Online April 2013.
151. Ali A. El-Emam, Abdul-Malek S. Al-Tamimi, Khalid A. Al-Rashood, Hriday N. Misra, Vijay Narayan, Onkar Prasad, Leena Sinha. Structural and spectroscopic characterization of a novel potential chemotherapeutic agent 3-(1-adamantyl)-1-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-methyl-1H-1,2,4-triazole-5(4H)-thione by first principle calculations. Journal of Molecular Structure, Volume 1022, 29 August 2012, Pages 49-60.
152. El-Emam AA, Al-Omar MA, Al-Tamimi AM, Ng SW, Tiekink ER. 3-(Adamantan-1-yl)-1-[(4-benzyl-piperazin-1-yl)meth-yl]-4-[(E)-(2-hy-droxy-benzyl-idene)amino]-1H-1,2,4-triazole-5(4H)-thione. Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1766-7. doi: 10.1107/S1600536812021204.
153. El-Emam AA, Alrashood KA, Al-Omar MA, Al-Tamimi AM. Synthesis and antimicrobial activity of N'-heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-adamantyl)-4-acetyl-5-[5-(4-substitutedphenyl-3-isoxazolyl)]-1,3,4-oxadiazolines. Molecules. 2012 Mar 16;17(3):3475-83. doi: 10.3390/molecules17033475.
154. El-Emam AA, Alrashood KA, Al-Tamimi AM, Ng SW, Tiekink ER. 3-(Adamantan-1-yl)-1-[(4-ethyl-piperazin-1-yl)meth-yl]-4-[(E)-(4-hy-droxy-benzyl-idene)amino]-1H-1,2,4-triazole-5(4H)-thione. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o657-8. doi: 10.1107/S1600536812005107.
155. El-Emam AA, Al-Omar MA, Al-Tamimi AM, Ng SW, Tiekink ER. 3-(Adamantan-1-yl)-4-methyl-1-[(4-phenyl-piperazin-1-yl)meth-yl]-1H-1,2,4-triazole-5(4H)-thione dichloro-methane hemisolvate. Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1772-3. doi: 10.1107/S1600536812021393.
156. Al-Tamimi AM, Bari A, Al-Omar MA, El-Emam AA, Ng SW. N'-[(2-n-Butyl-4-chloro-1H-imidazol-5-yl)-methyl-idene]adamantane-1-carbo-hydrazide sesquihydrate ethanol hemi-solvate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 31;66(Pt 8):o2131. doi: 10.1107/S1600536810029260.
157. Al-Tamimi AM, Bari A, Al-Omar MA, Alrashood KA, El-Emam AA. 3-(1-Adamant-yl)-1-{[4-(2-meth-oxy-phen-yl)piperazin-1-yl]meth-yl}-4-methyl-1H-1,2,4-triazole-5(4H)-thione. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 23;66(Pt 7):o1756. doi: 10.1107/S1600536810022695.

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