أعضاء هيئة التدريس | مواقع أعضاء هيئة التدريس

د.عبيد افضل محمد اكرم

أستاذ مشارك كلية الصيدلة بالخرج

كيمياء الصيدلة كلية الصيدلة الخرج 11942 المملكة العربية السعودية
011-588-6094
o.akram@psau.edu.sa

السيرة الذاتية
الأبحاث العلمية

المؤهلات العلمية

Ph.D (Pharmaceutical Chemistry)
Master of Pharmacy (M. Pharm.)
Bachelor of Pharmacy (B. Pharm.)
PostDoc

الخبرات

05/2024 - حتى الآن - Associate Professor - - Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, KSA.
08/2019 - 05/2024 - Assistant Professor - - Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, KSA.
04/2017 - 03/2019 - National Postdoctoral Fellow (SERB-DST) - Centre for Interdisciplinary Research in Basic Sciences (CIRBSc) at Jamia Millia Islamia, New Delhi, India.
08/2015 - 03/2017 - Assistant Professor - Goel Institute of Pharmacy and Sciences, Lucknow, India.
11/2014 - 06/2015 - Executive (API) in Regulatory Affairs Department - MYLAN INC., Hyderabad, India.

الأبحاث العلمية

1. Ahmad Firoz, Adeel Malik, Obaid Afzal, Vivekanand Jha. ContPro: a web tool for calculating amino acid contact distances in protein from 3D‐structures at different distance threshold. Bioinformation. 5(2), 55, 2010.
2. Nadeem Siddiqui, Andalip, Sandhya Bawa, Ruhi Ali, Obaid Afzal, M Jawaid Akhtar, Bishmillah Azad, Rajiv Kumar. Antidepressant potential of nitrogen-containing heterocyclic moieties: an updated review. Journal of Pharmacy and Bioallied Sciences. 3(2), 194, 2011.
3. Sandhya Bawa, Rajiv K Tonk, Gita Chawla, Suresh Kumar, Obaid Afzal. 1-(8-Chloro-3-methyl-1H-pyrazolo[4,3-c]cinnolin-1-yl)-2-(2-chlorophenyl) ethanone. Molbank. 2011(4), M744, 2011.
4. Obaid Afzal, Sandhya Bawa, Suresh Kumar, Rajiv K Tonk. Nꞌ-{[2-(Piperidin-1-yl)quinolin-3-yl]methylene}pyridine-4-carbohydrazide. Molbank. 2012(1), M748, 2012.
5. Rajiv Kumar Tonk, Sandhya Bawa, Gita Chawla, Girdhar Singh Deora, Suresh Kumar, Vandana Rathore, Naveen Mulakayala, Azad Rajaram, Arunasree M Kalle, Obaid Afzal. Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents. European Journal of Medicinal Chemistry. 57, 176-184, 2012.
6. Rajiv K Tonk, Gita Chawla, Suresh Kumar, Himanshu Gupta, Obaid Afzal. Pyrazole incorporated 1,2-diazanaphthalene derivatives: Synthesis and in-vivo pharmacological screening as anti-inflammatory and analgesic agents. African Journal of Pharmacy and Pharmacology. 6(6), 425-433, 2012.
7. Imran Kazmi, Mahfoozur Rahman, Muhammad Afzal, Gaurav Gupta, Shakir Saleem, Obaid Afzal, Md Adil Shaharyar, Ujjwal Nautiyal, Sayeed Ahmed, Firoz Anwar. Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara. Fitoterapia. 83(1), 142-146, 2012.
8. Muhammad Afzal, Gaurav Gupta, Imran Kazmi, Mahfoozur Rahman, Obaid Afzal, Jahangir Alam, Khalidur Rahman Hakeem, Mohammad Pravez, Ritu Gupta, Firoz Anwar. Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. Fitoterapia. 83(5), 853-858, 2012.
9. Obaid Afzal, Sandhya Bawa, Suresh Kumar, Rajiv Kumar, Md. Quamrul Hassan. Design, synthesis and evaluation of novel 2-piperidinyl quinoline chalcones/amines as potential antidepressant agents. Letters in Drug Design & Discovery. 10(1), 75-85, 2013.
10. Adeel Malik, Ahmad Firoz, Obaid Afzal, Vivekanand Jha, Inho Choi. Protein Structure Databases and 3D Structure Prediction Tools. Advances in Protein Chemistry. 2013.
11. Neelima Goel, Sushma Drabu, Obaid Afzal, Sandhya Bawa. Antimicrobial screening and one-pot synthesis of 4-(substituted-anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives. Journal of Pharmacy & Bioallied Sciences. 6(4), 253, 2014.
12. Obaid Afzal, Suresh Kumar, Rajiv Kumar, Manu Jaggi, Sandhya Bawa. 3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors. Journal of Pharmacy & Bioallied Sciences. 6(4), 260, 2014.
13. Suresh Kumar, Neeraj Upmanyu, Obaid Afzal, Sandhya Bawa. Synthesis and Antitubercular Screening of [(2‐Chloroquinolin‐3‐yl) methyl] Thiocarbamide Derivatives. Chemical Biology & Drug Design. 84(5), 522-530, 2014.
14. Mohd Rashid, Asif Husain, Mohammad Shaharyar, Ravinesh Mishra, Afzal Hussain, Obaid Afzal. Design and synthesis of pyrimidine molecules endowed with thiazolidin-4-one as new anticancer agents. European Journal of Medicinal Chemistry. 83, 630-645, 2014.
15. Obaid Afzal, Suresh Kumar, Rajiv Kumar, Ahmad Firoz, Manu Jaggi, Sandhya Bawa. Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors. Bioorganic & Medicinal Chemistry Letters. 24(16), 3986-3996, 2014.
16. Obaid Afzal, Suresh Kumar, Md Rafi Haider, Md Rahmat Ali, Rajiv Kumar, Manu Jaggi, Sandhya Bawa. A review on anticancer potential of bioactive heterocycle quinoline. European Journal of Medicinal Chemistry. 97, 871-910, 2015.
17. Suresh Kumar, Neelima Goel, Obaid Afzal, Md Rahmat Ali, Sandhya Bawa. In vitro antibacterial/antifungal screening of 2-chloroquinoline scaffold derivatives. Journal of Antibiotics Research. 1(1), 101, 2015.
18. Rahmat Ali, Suresh Kumar, Obaid Afzal, Sandhya Bawa. In-vitro antimicrobial screening and molecular docking studies of synthesized 2-chloro-N-(4-phenylthiazol-2-yl) acetamide derivatives. Drug Development & Therapeutics. 6(2), 2015.
19. Md Rahmat Ali, Suresh Kumar, Obaid Afzal, Nishtha Shalmali, Manju Sharma, Sandhya Bawa. Development of 2‐(substituted benzylamino)‐4‐methyl‐1, 3‐thiazole‐5‐carboxylic acid derivatives as xanthine oxidase inhibitors and free radical scavengers. Chemical Biology & Drug Design. 87(4), 508-516, 2016.
20. Obaid Afzal, Md Sayeed Akhtar, Suresh Kumar, Md Rahmat Ali, Manu Jaggi, Sandhya Bawa. Hit to lead optimization of a series of N-[4-(1, 3-benzothiazol-2-yl) phenyl] acetamides as monoacylglycerol lipase inhibitors with potential anticancer activity. European Journal of Medicinal Chemistry. 121, 318-330, 2016.
21. Md. Rahmat Ali, Suresh Kumar, Obaid Afzal, Nishtha Shalmali, Wazid Ali, Manju Sharma and Sandhya Bawa. 2-Benzamido-4-methylthiazole-5-carboxylic Acid Derivatives as Potential Xanthine Oxidase Inhibitors and Free Radical Scavengers. Archiv der Pharmazie. 350(2), 1600313, 2017.
22. Md Rahmat Ali, Suresh Kumar, Nishtha Shalmali, Obaid Afzal, Sabir Azim, Damini Chanana, Ozair Alam, Yam Nath Paudel, Manju Sharma, Sandhya Bawa. Development of Thiazole-5-carboxylate Derivatives as Selective Inhibitors of Monoacylglycerol Lipase as Target in Cancer. Mini Reviews in Medicinal Chemistry. 19(5), 410-423, 2019.
23. Md Quamrul Hassan, Md Sayeed Akhtar, Obaid Afzal, Ibraheem Hussain, Mohd Akhtar, Syed Ehtaishamul Haque, Abul Kalam Najmi. Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced cardiotoxicity. Clinical and Experimental Hypertension. 42(5), 381-392, 2020.
24. Abdulmalik Saleh Alfawaz Altamimi, Sandhya Bawa, Fareeda Athar, Md Quamrul Hassan, Yassine Riadi, Obaid Afzal. Pyrrolidin‐2‐one linked benzofused heterocycles as novel small molecule monoacylglycerol lipase inhibitors and antinociceptive agents. Chemical Biology & Drug Design. 96(6), 1418-1432, 2020.
25. Rehan Abdur Rub, Sarwar Beg, Imran Kazmi, Obaid Afzal, Waleed H. Almalki, Saad Alghamdi, Sohail Akhter, Asgar Ali, Farhan J. Ahmed. Systematic development of a bioanalytical UPLC-MS/MS method for estimation of risperidone and its active metabolite in long-acting microsphere formulation in rat plasma. Journal of Chromatography B. 1160, 122433, 2020.
26. M. A. Alamri, Obaid Afzal, M.A. Alamri. Computational screening of natural and natural-like compounds to identify novel ligands for sigma-2 receptor. SAR and QSAR in Environmental Research. 31(11), 837-856, 2020.
27. Mahfoozur Rahman, Waleed H Almalki, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Hani Choudhry, Sattam K Alenezi, Md Abul Barkat, Sarwar Beg, Vikas Kumar, Abdulsalam Alhalmi. Cationic Solid Lipid Nanoparticles of Resveratrol for Hepatocellular Carcinoma Treatment: Systematic Optimization, in vitro Characterization and Preclinical Investigation. International Journal of Nanomedicine. 15, 9283-9299, 2020.
28. Predeepkumar Narayanappa Shiroorkar, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Kumar Shiva Gubbiyappa, Nagaraja Sreeharsha. Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction. Molecules. 25(23), 5622, 2020.
29. Zonghua Shi, Majed Alrobaian, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Waleed H. Almalki, Abdullah A. Baothman, Hani Choudhry, Mahfoozur Rahman. Cationic self-nanoemulsifying formulations of tamoxifen with improved biopharmaceutical attributes and anticancer activity: Systematic development and evaluation. Journal of Molecular Liquids. 320, 114534, 2020.
30. Ying Zhang, Jing Zhao, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik S. A. Altamimi, Zhen Yang. Neuroprotective role of chrysin‐loaded poly(lactic‐co‐glycolic acid) nanoparticle against kindling‐induced epilepsy through Nrf2/ARE/HO‐1 pathway. Journal of Biochemical and Molecular Toxicology. 35(2), e22634, 2021.
31. Sarwar Beg, Ankit K Malik, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Waleed H Almalki, Md Abul Barkat, SM Kawish, Debi Prasad Pradhan. Systematic Development and Validation of a RP-HPLC Method for Estimation of Abiraterone Acetate and its Degradation Products. Journal of Chromatographic Science. 59(1), 79-87, 2021.
32. Mahfoozur Rahman, Waleed H Almalki, Imran Kazmi, Obaid Afzal, Hanadi A Katouah, Majed Alrobaian, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Mohammed S Alshammari, Rehan Abdur Rub. Development and validation of a new UPLC-MS/MS method for quantification of ganoderic acid-A loaded nanolipidic carrier in rat plasma and application to pharmacokinetic studies. Journal of Chromatography B. 1163, 122501, 2021.
33. Mahfoozur Rahman, Waleed H Almalki, Obaid Afzal, Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Saad Alghamdi, Fahad A Al-Abbasi, Waleed M Altowayan, Majed Alrobaian, Khalid S.Alharbi. Diosmin-loaded solid nanoparticles as nano-antioxidant therapy for management of hepatocellular carcinoma: QbD-based optimization, in vitro and in vivo evaluation. Journal of Drug Delivery Science and Technology. 61, 102213, 2021.
34. Mohammad Islamuddin, Obaid Afzal, Wajihul Hasan Khan, Malik Hisamuddin, Abdulmalik Saleh Alfawaz Altamimi, Ibraheem Husain, Kentaro Kato, Mubarak A Alamri, Shama Parveen. Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-Methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins. ACS omega. 6(14), 9791–9803, 2021.
35. Sarwar Beg, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Waleed H Almalki, Saad Alghamdi, Majed Alrobaian, Khalid S Alharbi, Mohammed S. Alshammari. Implications of phospholipid-based nanomixed micelles of olmesartan medoxomil with enhanced lymphatic drug targeting ability and systemic bioavailability. Journal of Drug Delivery Science and Technology. 62, 102273, 2021.
36. Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Mir Mohammad Shahroz, Hemant Kumar Sharma, Yassine Riadi, Md Quamrul Hassan. Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase. Molecules. 26(8), 2389, 2021.
37. Mohammad Khalid, Mohammed H. Alqarni, Ambreen Shoaib, Muhammad Arif, Ahmed I. Foudah, Obaid Afzal, Abuzer Ali, Amena Ali, Saad S. Alqahtani, Abdulmalik S. A. Altamimi. Anti-Arthritic and Anti-Inflammatory Potential of Spondias mangifera Extract Fractions: An In Silico, In Vitro and In Vivo Approach. Plants. 10(5), 825, 2021.
38. Mubarak A Alamri, Muhammad Tahir ul Qamar, Obaid Afzal, Alhumaidi B Alabbas, Yassine Riadi, Safar M Alqahtani. Discovery of anti-MERS-CoV small covalent inhibitors through pharmacophore modeling, covalent docking and molecular dynamics simulation. Journal of Molecular Liquids. 330, 115699, 2021.
39. Mohammad Rashid, Obaid Afzal, Altamimi, Abdulmalik Saleh Alfawaz. BENZIMIDAZOLE MOLECULE HYBRID WITH OXADIAZOLE RING AS ANTIPROLIFERATIVE AGENTS: IN-SILICO ANALYSIS, SYNTHESIS AND BIOLOGICAL EVALUATION. Journal of the Chilean Chemical Society. 66(2), 5164-5182, 2021.
40. Yang Gao, Waleed H. Almalki, Obaid Afzal, Sunil K. Panda, Imran Kazmi, Majed Alrobaian, Hanadi A. Katouah, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Sultan Alshehri, Kriti Soni, Ibrahim Abdel Aziz Ibrahim, Mahfoozur Rahman, Beg Sarwar. Systematic development of lectin conjugated microspheres for nose-to-brain delivery of rivastigmine for the treatment of Alzheimer’s disease. Biomedicine & Pharmacotherapy. 141, 111829, 2021.
41. Afzal Hussain, Obaid Afzal, Abdulmalik S.A. Altamimi, Raisuddin Ali. Application of green nanoemulsion to treat contaminated water (bulk aqueous solution) with azithromycin. Environmental Science and Pollution Research. 28, 61696–61706, 2021.
42. Bin Wang, Lin Sun, Mingyun Wen, Youchun Tan, Waleed H Almalki, Hanadi Katouah, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Majed Alrobaian, Khalid S Alharbi, Sattam K Alenezi, Adel F. Alghaith, Sarwar Beg, Rahman Mahfoozur. Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma. Saudi Pharmaceutical Journal. 29(8), 843-856, 2021.
43. Afzal Hussain, Sultan Alshehri, Mohd Ramzan, Obaid Afzal, Abdulmalik S. A. Altamimi, Manal A. Alossaimi. Biocompatible solvent selection based on thermodynamic and computational solubility models, in-silico GastroPlus prediction, and cellular studies of ketoconazole for subcutaneous delivery. Journal of Drug Delivery Science and Technology. 65, 102699, 2021.
44. Maged S Abdel-Kader, Prawez Alam, Gamal A Soliman, Ramadan Al-Shdefat, Obaid Afzal. Eco-friendly stability-indicating RP-HPTLC method for sildenafil analysis, characterization and biological evaluation of its oxidized stress degradation product. Scientific Reports. 11(1), 1-14, 2021.
45. Sherif A Abdel-Gawad, Obaid Afzal. Spectrodensitometric and ultra-performance liquid chromatographic quantification of dapagliflozin and saxagliptin in their dosage form and human plasma. Tropical Journal of Pharmaceutical Research. 20(6), 1223-1231, 2021.
46. Rahul Chadar, Obaid Afzal, Safar M. Alqahtani, Prashant Kesharwani. Carbon nanotubes as an emerging nanocarrier for the delivery of doxorubicin for improved chemotherapy. Colloids and Surfaces B: Biointerfaces. 208, 112044, 2021.
47. Sherif A. Abdel-Gawad, Obaid Afzal, Hany H. Arab, Alhumaidi B. Alabbas and Abdulmalik M. Alqarni. Fabrication of membrane sensitive electrodes for the validated electrochemical quantification of anti-osteoporotic drug residues in pharmaceutical industrial wastewater. Molecules. 26(16), 5093, 2021.
48. Shadab Md, Nabil A Alhakamy, Mohamed A Alfaleh, Obaid Afzal, Abdulmalik SA Altamimi, Ashif Iqubal, Rasheed A Shaik. Mechanisms Involved in Microglial-Interceded Alzheimer’s Disease and Nanocarrier-Based Treatment Approaches. Journal of Personalized Medicine. 11(11), 1116, 2021.
49. Lihua Chen, Majed Alrobaian, Obaid Afzal, Imran Kazmi, Sunil K. Panda, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Waleed H. Almalki, Hanadi A. Katouah, Tanuja Singh, Kriti Soni, Abdul Hafeez, Sarwar Beg, Vikas Kumar, Mahfoozur Rahman. Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro, in vivo evaluation, and dermatokinetic studies. Drug Delivery. 28(1), 1972-1981, 2021.
50. M.A. Alamri, A.D. Alafnan, Obaid Afzal, A.B. Alabbas, S.M. Alqahtani. Structure prediction of SPAK C-terminal domain and analysis of its binding to RFXV/I motifs by homology modelling, docking, and molecular dynamics simulation studies. Current Computer-Aided Drug Design. 17(5), 666-675, 2021.
51. Obaid Afzal, Tuhfa, Mubarak A. Alamri, Abdulmalik S. A. Altamimi, Abdul Roouf Bhat, Fareeda Athar. Thiazolidinone Derivatives: Synthesis, Characterization, Antimicrobial Evaluation, and Cytotoxicity Studies. Indian Journal of Heterocyclic Chemistry. 31(4), 621-634, 2021.
52. Vetriselvan Subramaniyan, Shivkanya Fuloria, Gaurav Gupta, Darnal Hari Kumar, Mahendran Sekar, Kathiresan Sathasivam, Kalvatala Sudhakar, Khalid Saad Alharbi, Waleed Hassan Al-Malki, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Neeraj Kumar Fuloria. A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer. Chemico-Biological Interactions. 351, 109735, 2022.
53. Majed Alrobaian, Sagar Suman Panda, Obaid Afzal, Imran Kazmi, Manal A Alossaimi, Fahad A Al-Abbasi, Waleed H Almalki, Kriti Soni, Ozair Alam, Md Naushad Alam, Rehan A Rub, Mahfoozur Rahman, Sarwar Beg. Development of a Validated Bioanalytical UPLC–MS/MS Method for Quantification of Neratinib: A Recent Application to Pharmacokinetic Studies in Rat Plasma. Journal of Chromatographic Science. 60(6), 551–558, 2022.
54. Majed Alrobaian, Sagar Suman Panda, Waleed H Almalki, Obaid Afzal, Imran Kazmi, Manal A Alossaimi, Fahad A Al-Abbasi, Hanadi A Katouah, Rehan A Rub, BVV Kumar, Mahfoozur Rahman, Sarwar Beg. Development and Validation of Chemometrics-Assisted Green UPLC-MS/MS Bioanalytical Method for Simultaneous Estimation of Capecitabine and Lapatinib in Rat Plasma. Journal of Chromatographic Science. 60(6), 559–570, 2022.
55. Mahfoozur Rahman, Obaid Afzal, Sunil K Panda, Imran Kazmi, Ahmed Mahmoud Abdelhaleem Ali, Manal A Alossaimi, Fahad A Al-Abbasi, Waleed H Almalki, Hanadi A Katouah, Vikas Kumar, Md Abul Barkat, Rehan A Rub, Sarwar Beg. UPLC–MS/MS Method Validation for Estimation of Resveratrol in Rat Skin from Liposphere Gel Formulation and Its Application to Dermatokinetic Studies in Rats. Journal of Chromatographic Science. 60(7), 663–670, 2022.
56. Yassine Riadi, Obaid Afzal, Abdul-Malek S Al-Tamimi, Abuzer Ali, Amena Ali. Ultrasonic-Mediated Green Synthesis of Novel S-Arylated-Pyridopyrimidines and Antimicrobial Evaluation against Escherichia coli and Staphylococcus aureus. Polycyclic Aromatic Compounds. 42(9), 6546-6553, 2022.
57. Shumin Li, Zhongkai Xu, Majed Alrobaian, Obaid Afzal, Imran Kazmi, Waleed H. Almalki, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Khalid S Alharbi, Waleed M Altowayan, Tanuja Singh, Md Habban Akhter, Manish Gupta, Mahfoozur Rahman, Sarwar Beg. EGF-functionalized lipid-polymer hybrid nanoparticles of 5-Fluorouracil and Sulphoraphane with enhanced bioavailability and anticancer activity against colon carcinoma. Biotechnology and Applied Biochemistry. 69(5), 2205-2221, 2022.
58. Afzal Hussain, Mohammad A. Altamimi, Obaid Afzal, Abdulmalik S. A. Altamimi, Abuzer Ali, Amena Ali, Fleming Martinez, Mohd Usman Mohd Siddique, William E. Acree Jr., Abolghasem Jouyban. Preferential Solvation Study of the Synthesized Aldose Reductase Inhibitor (SE415) in the {PEG 400 (1) + Water (2)} Cosolvent Mixture and GastroPlus-Based Prediction. ACS Omega. 7(1), 1197–1210, 2022.
59. Afzal Hussain, Obaid Afzal, Abdulmalik S.A. Altamimi, Abuzer Ali, Amena Ali, Fleming Martinez, Mohd Usman Mohd Siddique, William E. Acree Jr, Naushad Ali. Preferential solvation study of (Z)-N-benzyl-2-{5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetamide(3) in {NMP (1) + Water (2)} co-solvent mixture and GastroPlus software based in vitro simulation. Journal of Molecular Liquids. 349, 118491, 2022.
60. Md Habban Akhter, Irfan Ahmad, Mohammad Y. Alshahrani, Alhanouf I. Al-Harbi, Habibullah Khalilullah, Obaid Afzal, Abdulmalik S.A. Altamimi, Shehla N.M. Najib Ullah, Abhijeet Ojha, Shahid Karim. Drug Delivery Challenges and Current Progress in Nanocarrier-Based Ocular Therapeutic System. Gels. 8(2), 82, 2022.
61. Khalid Saad Alharbi, Obaid Afzal, Waleed Hassan Al-Malki, Imran Kazmi, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Monica Gulati, Sachin K. Singh, Niraj Kumar Gupta, Piyush Kumar Jha, Dinesh Kumar Chellappan, Brian George Oliver, Kamal Dua, Gaurav Gupta. Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases. Chemico-Biological Interactions. 354, 109842, 2022.
62. Mir Mohammad Shahroz, Hemant Kumar Sharma, Abdulmalik S. A. Altamimi, Mubarak A. Alamri, Abuzer Ali, Amena Ali, Safar Alqahtani, Ali Altharawi, Alhumaidi B. Alabbas, Manal A. Alossaimi, Yassine Riadi, Ahmad Firoz, Obaid Afzal. Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study. Molecules. 27(4), 1159, 2022.
63. Mohammad Islamuddin, Abuzer Ali, Obaid Afzal, Amena Ali, Intzar Ali, Abdulmalik Saleh Alfawaz Altamimi, Mubarak A. Alamri, Kentaro Kato, and Shama Parveen. Thymoquinone Induced Leishmanicidal Effect via Programmed Cell Death in Leishmania donovani. ACS Omega. 7(12), 10718-10728, 2022.
64. Khalid Saad Alharbi, Yogendra Singh, Waleed Hassan Almalki, Sushama Rawat, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Sachin Kumar Singh, Shvetank Bhatt, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta. Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora. Chemico-Biological Interactions. 358, 109898, 2022.
65. Shahid Karim, Md Habban Akhter, Abdulhadi S. Burzangi, Huda Alkreathy, Basma Alharthy, Sabna Kotta, Shadab Md, Md Abdur Rashid, Obaid Afzal, Abdulmalik S. A. Altamimi, Habibullah Khalilullah. Phytosterol-Loaded Surface-Tailored Bioactive-Polymer Nanoparticles for Cancer Treatment: Optimization, In Vitro Cell Viability, Antioxidant Activity, and Stability Studies. Gels. 8(4), 219, 2022.
66. Kumar Venkatesan, Nazima Haider, Mohammad Yusuf, Afzal Hussain, Obaid Afzal, Sabina Yasmin, Abdulmalik S.A. Altamimi. Water/transcutol/lecithin/M− 812 green cationic nanoemulsion to treat oxytetracycline contaminated aqueous bulk solution. Journal of Molecular Liquids. 357, 119154, 2022.
67. Mohammad Arshad Javed Shaikh, Khalid Saad Alharbi, Waleed Hassan Almalki, Syed Sarim Imam, Mohammed Albratty, Abdulkarim M. Meraya, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Yogendra Singh, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta. Sodium alginate based drug delivery in management of breast cancer. Carbohydrate Polymers. 292, 119689, 2022.
68. Mayank Handa, Waleed H. Almalki, Rahul Shukla, Obaid Afzal, AbdulMalik Saleh Alfawaz Altamimi, Sarwar Beg, Mahfoozur Rahman. Active pharmaceutical ingredients (APIs) in ionic liquids: an effective approach for API physiochemical parameter optimization. Drug Discovery Today. 27(9), 2415-2424, 2022.
69. M.A. Alossaimi, A.S.A. Altamimi, S.M. Alqahtani, M.Z. Hassan, M. Rashid, M. Kamal, Obaid Afzal. HPLC Method Development and Validation for the Estimation of Thymoquinone in Nigella sativa Seed Extract by Quality by Design (QbD) Approach. Latin American Journal of Pharmacy. 41(6), 1110-1118, 2022.
70. S.M. Kawish, Shwetakshi Sharma, Waleed H Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Sarwar Beg and Farhan J Ahmad. Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes. Current Drug Metabolism. 23(8), 616 – 629, 2022.
71. Suman Rohilla, Mahaveer Singh, Sami I. Alzarea, Waleed Hassan Al-Malki, Fahad A. Al-Abbasi, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta. Recent developments and challenges in the molecular targeted therapies of non-small cell lung cancer. Journal of Environmental Pathology, Toxicology and Oncology. 42(1), 27-50, 2022.
72. Obaid Afzal, Hisham Abdulaziz Alshammari, Mohammad A. Altamimi, Afzal Hussain, Basmah Almohaywi, Abdulmalik S.A. Altamimia. Hansen solubility parameters and green nanocarrier based removal of trimethoprim from contaminated aqueous solution. Journal of Molecular Liquids. 361, 119657, 2022.
73. Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta. A narrative review on the biology of piezo1 with platelet-rich plasma in cardiac cell regeneration. Chemico-Biological Interactions. 363, 110011, 2022.
74. S. J. Aljurbui, A. Hussain, M. Yusuf, M. Ramzan, Obaid Afzal, B. Almohaywi, S. Yasmin, A.S.A. Altamimi. Impact of Composition and Morphology of Ketoconazole-Loaded Solid Lipid Nanoparticles on Intestinal Permeation and Gastroplus-Based Prediction Studies. ACS Omega. 7(26), 22406–22420, 2022.
75. Khalid Saad Alharbi, Tabinda Ali, Yogendra Singh, Ahmed Saleh Ali Al-Ghamdi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta. Biochemical interaction of pyrvinium in gentamicin-induced acute kidney injury by modulating calcium dyshomeostasis and mitochondrial dysfunction. Chemico-Biological Interactions. 363, 110020, 2022.
76. Madhu Gupta, Vikas Sharma, Kalicharan Sharma, Anoop Kumar, Ajay Sharma, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Gaurav Gupta, Keshav Raj Paudel, Philip M. Hansbro, Kamal Dua. A kNGR Peptide-Tethered Lipid–Polymer Hybrid Nanocarrier-Based Synergistic Approach for Effective Tumor Therapy: Development, Characterization, Ex-Vivo, and In-Vivo Assessment. Pharmaceutics. 14(7), 1401, 2022.
77. Sarwar Beg, Mayank Handa, Rahul Shukla, Mahfoozur Rahman, Waleed H. Almalki, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi. Wearable smart devices in cancer diagnosis and remote clinical trial monitoring: transforming the healthcare applications. Drug Discovery Today. 27(10), 103314, 2022.
78. Khalid Saad Alharbi, Navneet Joshi, Yogendra Singh, Waleed Hassan almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Gaurav Gupta. Molecular exploration of hidden pleiotropic activities of azoles on dermatophytes in human tinea corporis infection. Journal of Medical Mycology. 32(4), 101311, 2022.
79. M.A. Beg, Shivangi, Obaid Afzal, M.S. Akhtar, A.S.A. Altamimi, A. Hussain, M.A. Imam, M.N. Ahmad, S. Chopra, F. Athar. Potential Efficacy of β-Amyrin Targeting Mycobacterial Universal Stress Protein by In Vitro and In Silico Approach. Molecules. 27(14), 4581, 2022.
80. M.A. Shaharyar, R. Bhowmik, Obaid Afzal, A.S.A. Altamimi, S.I. Alzarea, W.H. Almalki, S.Z. Ali, P. Mandal, A. Mandal, M. Ayoob, I. Kazmi, S. Karmakar. Anti-Hypertensive Activity of Some Selected Unani Formulations: An Evidence-Based Approach for Verification of Traditional Unani Claims Using LC-MS/MS for the Evaluation of Clinically Relevant Blood Parameters in Laboratory Rats. Journal of Clinical Medicine. 11(15), 4628, 2022.
81. Obaid Afzal, Md Habban Akhter, Irfan Ahmad, Khursheed Muzammil, Adam Dawria, Mohammad Zeyaullah, Abdulmalik SA Altamimi, Habibullah Khalilullah, Shehla Nasar Mir Najib Ullah, Mohammad Akhlaquer Rahman, Abuzer Ali, Naiyer Shahzad, Mariusz Jaremko, Abdul-Hamid Emwas, Ibrahim Abdel Aziz Ibrahim. A β–Sitosterol Encapsulated Biocompatible Alginate/Chitosan Polymer Nanocomposite for the Treatment of Breast Cancer. Pharmaceutics. 14(8), 1711, 2022.
82. Khalid Saad Alharbi, Mohammad Arshad Javed Shaikh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta. An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy. Chemico-Biological Interactions. 366, 110108, 2022.
83. Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M Balaramnavar, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Gaurav Gupta, Madan Mohan Gupta. Anti-Cancer Phytochemical-Based Nano-Formulations: Therapeutic Intervention in Cancer Cell Lines. Journal of Environmental Pathology, Toxicology and Oncology. 42(1), 79-93, 2022.
84. Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan. Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.). Metabolites. 12(9), 854, 2022.
85. Khalid Saad Alharbi, Yogendra Singh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Dinesh Kumar Chellappan, Sachin Kumar Singh, Kamal Dua & Gaurav Gupta. Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders. Molecular Biology Reports. 49(11), 11101–11111, 2022.
86. Khalid Saad Alharbi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik S. A. Altamimi, Waleed Hassan Almalki, Muhammad Shahid Nadeem, Muhammad Afzal, Nadeem Sayyed, Imran Kazmi. Effects of the Anthocyanin Hirsutidin on Gastric Ulcers: Improved Healing through Antioxidant Mechanisms. Journal of Natural Products. 85(10), 2406–2412, 2022.
87. Mohamed Jawed Ahsan, Amena Ali, Abuzer Ali, Arunkumar Thiriveedhi, Mohammed A. Bakht, Mohammad Yusuf, Salahuddin, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi. Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders. ACS Omega. 7(43), 38207–38245, 2022.
88. Obaid Afzal, Mohammad Yusuf, Mohamed Jawed Ahsan, Abdulmalik Saleh Alfawaz Altamimi, Md. Afroz Bakht, Amena Ali, Salahuddin. Chemical Modification of Curcumin into Its Semi-Synthetic Analogs Bearing Pyrimidinone Moiety as Anticancer Agents. Plants. 11(20), 2737, 2022.
89. Obaid Afzal, Abdulmalik S. A. Altamimi, Bismillah Mubeen, Sami I. Alzarea, Waleed Hassan Almalki, Salwa D. Al-Qahtani, Eman M. Atiya, Fahad A. Al-Abbasi, Fatima Ali, Inam Ullah, Muhammad Shahid Nadeem, Imran Kazmi. mTOR as a Potential Target for the Treatment of Microbial Infections, Inflammatory Bowel Diseases, and Colorectal Cancer. International Journal of Molecular Sciences. 23(20), 12470, 2022.
90. Khalid Saad Alharbi, Mohammad Arshad Javed Shaikh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, M Ravindra Babu, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta. Oligonucleotides: A novel area of interest for drug delivery in neurodegenerative diseases. Journal of Drug Delivery Science and Technology. 77, 103849, 2022.
91. Huan Li, Jian Li, Juanli Wang, Obaid Afzal, Abdulmalik SA Altamimi, Shehla Nasar Mir Najib Ullah, Sireen Abdul Rahim Shilbayeh, Alnada Abdalla Ibrahim, Shahanavaj Khan. Analysis of Anti-Arrhythmic Impacts of Crocin through Estimation of Expression of Cx43 in Myocardial Infarction Using a Rat Animal Model. ACS Omega. 7(42), 37164–37169, 2022.
92. Pankaj Kumar, Bharti Mangla, Sarwar Beg, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed H. Almalki, Shehla Nasar Mir Najib Ullah, Geeta Aggarwal. Optimization and validation of stability indicating RP-HPLC method for the quantification of gefitinib in bulk drug and nanoformulations: An application towards in vitro and ex vivo performance evaluation. Arabian Journal of Chemistry. 15(12), 104333, 2022.
93. Asma B. Omer, Mahmood Hassan Dalhat, Mohammad Kaleem Khan, Obaid Afzal, Abdulmalik S. A. Altamimi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi. Butin Mitigates Memory Impairment in Streptozotocin-Induced Diabetic Rats by Inhibiting Oxidative Stress and Inflammatory Responses. Metabolites. 12(11), 1050, 2022.
94. Obaid Afzal, Mahmood Hassan Dalhat, Abdulmalik S. A. Altamimi, Rabia Rasool, Sami I. Alzarea, Waleed Hassan Almalki, Bibi Nazia Murtaza, Saima Iftikhar, Shamaila Nadeem, Muhammad Shahid Nadeem, Imran Kazmi. Green tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits. Molecules. 27(21), 7604, 2022.
95. Tahreem Fiaz, Muhammad Shahid Nadeem, Obaid Afzal, Abdulmalik S. A. Altamimi, Sami I. Alzarea, Waleed Hassan Almalki, Hafsa Ahmed Khan, Iahtisham-Ul-Haq, Sharoon Hanook, Imran Kazmi, Muhammad Mustafa. Peripheral mRNA Expression and Prognostic Significance of Emotional Stress Biomarkers in Metastatic Breast Cancer Patients. International Journal of Molecular Sciences, 23(22), 14097, 2022.
96. Md Sayeed Akhtar, Md Quamrul Hassan, Obaid Afzal, Abdulmalik S.A. Altamimi, Mohd Zaheen Hassan, Arun Kumar, Asif Ansari Shaik Mohammad, Fauzia Tabassum. Comparative efficacy of levosimendan, ramipril, and sacubitril/valsartan in isoproterenol induced experimental heart failure: a hemodynamic and molecular approach. Current Molecular Pharmacology. 16(6), 629-639, 2022.
97. Khalid Saad Alharbi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Hafiz A. Makeen, Mohammed Albratty. Potential role of nutraceuticals via targeting a Wnt/β-catenin and NF-κB pathway in treatment of osteoarthritis. Journal of Food Biochemistry. 46(12):e14427, 2022.
98. Khalid Saad Alharbi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Hafiz A. Makeen, Mohammed Albratty. A study of the molecular mechanism of quercetin and dasatinib combination as senolytic in alleviating age-related and kidney diseases. Journal of Food Biochemistry. 46(12), e14471, 2022.
99. Afzal Hussain, Obaid Afzal, Mohammad A Altamimi, Abdulmalik Saleh Alfawaz Altamimi, Mohhammad Ramzan, Mohd Zaheen Hassan, Wael A Mahdi, Thomas J Webster. Improved Subcutaneous Delivery of Ketoconazole Using EpiDerm and HSPiP Software-Based Simulations as Assessed by Cell Viability, Cellular Uptake, Permeation, and Hemolysis in Vitro Studies. ACS Omega. 7(46), 42593–42606, 2022.
100. Rajeshwar Kamal Kant Arya, Juyal Vijay, Dheeraj Bisht, Mohammad Rashid, Abdulmalik Saleh Alfawaz Altamimi, Obaid Afzal, Neeraj Kumar Sethiya. Enhanced Brain Delivery via Intranasal Administration of Carbamazepine Loaded Solid Lipid Nanoparticles: Optimization, Pharmacokinetic analysis, In-vitro and In-vivo Drug Release Study. Current Drug Delivery. 20(5), 587-600, 2022.
101. Mahfoozur Rahman, Joina Gunjan Singh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Majed Alrobaian, Jamshed Haneef, Md Abul Barkat, Waleed H Almalki, Mayank Handa, Rahul Shukla, Shehla Nasar Mir Najib Ullah, Vikas Kumar, Sarwar Beg. Preparation, Characterization, and Evaluation of Curcumin–Graphene Oxide Complex-Loaded Liposomes against Staphylococcus aureus in Topical Disease. ACS Omega. 7(48), 43499–43509, 2022.
102. Asif Ahmad Bhat, Gaurav Gupta, Khalid Saad Alharbi, Obaid Afzal, Abdulmalik SA Altamimi, Waleed Hassan Almalki, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Dinesh Kumar Chellappan, Sachin Kumar Singh, Ronan MacLoughlin, Brian G Oliver, Kamal Dua. Polysaccharide-Based Nanomedicines Targeting Lung Cancer. Pharmaceutics. 14(12), 2788, 2022.
103. Khalid Saad Alharbi, Muhammad Shahid Nadeem, Obaid Afzal, Sami I Alzarea, Abdulmalik SA Altamimi, Waleed Hassan Almalki, Bismillah Mubeen, Samia Iftikhar, Luqman Shah, Imran Kazmi. Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications. Metabolites. 12(12), 1274, 2022.
104. Obaid Afzal, Abdulmalik S. A. Altamimi, Muhammad Shahid Nadeem, Sami I. Alzarea, Waleed Hassan Almalki, Aqsa Tariq, Bismillah Mubeen, Bibi Nazia Murtaza, Saima Iftikhar, Naeem Riaz, Imran Kazmi. Nanoparticles in Drug Delivery: From History to Therapeutic Applications. Nanomaterials. 12(24), 4494, 2022.
105. Gupta KK, Sharma KK, Chandra H, Panwar H, Bhardwaj N, Altwaijry NA, Alsfouk AA, Dlamini Z, Afzal O, Altamimi AS, Khan S. The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule: Targeting cancer cells signaling PI3K and AKT kinase pathway. Frontiers in oncology. 2022 Dec 15;12:950835.
106. Mahfoozur Rahman, Waleed H. Almalki, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Shehla Nasar Mir Najib Ullah, Md. Abul Barkat, Sarwar Beg. Chiral-engineered supraparticles: Emerging tools for drug delivery. Drug Discovery Today. 28(1), 103420, 2023.
107. Benu Chaudhary, Deepak Singla, Preeti Arya, Abhishek Dabra, Parveen Kumar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Gaurav Gupta, Madan Mohan Gupta. Versatile Imidazole Synthesis Via Multicomponent Reaction Approach. Journal of Heterocyclic Chemistry. 60(4), 523-536, 2023.
108. Md Sayeed Akhtar, Md Quamrul Hassan, Aisha Siddiqui, Sirajudeen S Alavudeen, Obaid Afzal, Abdulmalik SA Altamimi, Syed Obaidur Rahman, Mallika Khurana, Mohamed Jawed Ahsan, Arun Kumar, Fauzia Tabassum. Levosimendan: mechanistic insight and its diverse future aspects in cardiac care. Acta Cardiologica. 78(2), 170-187, 2023.
109. Mahfoozur Rahman, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Majed Alrobaian, Md. Abul Barkat, Shehla Nasar Mir Najib Ullah, Waleed H. Almalki, Tanuja Singh, Sarwar Beg, Hani Choudhry. Paclitaxel and Curcumin as Dual-Drug-Loaded Lipid Nanocapsules in the Management of Brain Tumour. Journal of Cluster Science. 2022. 34, 1927–1938, 2023.
110. Barkat, M. Rahman, K.S. Alharbi, W.M. Altowayan, M. Alrobaian, Obaid Afzal, A.S.A. Altamimi, F.S. Alhodieb, W.H. Almalki, H. Choudhry, T. Singh, S. Beg. Biocompatible Polymeric Nanoparticles for Effective Codelivery of Tamoxifen with Ganoderic Acid A: Systematic Approach for Improved Breast Cancer Therapeutics. Journal of Cluster Science. 2022. 34, 1483–1497, 2023.
111. Obaid Afzal, Gopal Prasad Agrawal, Ghadah Rashed Ghazi Alotaibi, Raid Saleh Ali Shatat, Habibullah Khalilullah, Zabih Ullah, Mohammad Rashid, Ahmed F Elkirdasy, Benson Mathai K. Design, Synthesis and Molecular Docking Studies of (S)-1-(2-(substituted benzylamino)-3-methylbutanoyl)pyrrolidin-2-one analogues as GABA Mediated Anticonvulsant agents. Indian Journal of Pharmaceutical Education and Research. 57(1), 182-193, 2023.
112. Asif Ahmed Bhat, Gaurav Gupta, Obaid Afzal, Imran Kazmi, Fahad A Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I Alzarea, Sachin Kumar Singh, Kamal Dua. Neuropharmacological effect of risperidone: From chemistry to medicine. Chemico-Biological Interactions. 369, 110296, 2023.
113. Mohammad Adnan, Obaid Afzal, Abdulmalik SA Altamimi, Mubarak A Alamri, Tanweer Haider, Md Faheem Haider. Development and optimization of transethosomal gel of apigenin for topical delivery: In-vitro, ex-vivo and cell line assessment. International Journal of Pharmaceutics. 631, 122506, 2023.
114. Bharti Chauhan, Rajnish Kumar, Salahuddin, Himanshu Singh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Mohd Mustaqeem Abdullah, Mohammad Shahar Yar, Mohamed Jawed Ahsan, Neeraj Kumar, Sanjay Kumar Yadav. Design, Synthesis, In Vivo, and In Silico Evaluation of Benzothiazoles Bearing a 1,3,4-Oxadiazole Moiety as New Antiepileptic Agents. ACS Omega. 8(2), 2520–2530, 2023.
115. Manish Purohit, Gaurav Gupta, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sami I Alzarea, Imran Kazmi, Waleed Hassan Almalki, Monica Gulati, Indu Pal Kaur, Sachin Kumar Singh, Kamal Dua. Janus kinase/signal transducers and activator of transcription (JAK/STAT) and its role in Lung inflammatory disease. Chemico-Biological Interactions. 371, 110334, 2023.
116. Sumel Ashique, Obaid Afzal, Sabina Yasmin, Afzal Hussain, Mohammad A Altamimi, Thomas J Webster, Abdulmalik SA Altamimi. Strategic nanocarriers to control neurodegenerative disorders: concept, challenges, and future perspective. International Journal of Pharmaceutics. 633, 122614, 2023.
117. Yassine Riadi, Obaid Afzal, Mohammed H Geesi, Waleed H Almalki, Tanuja Singh. Baicalin-Loaded Lipid–Polymer Hybrid Nanoparticles Inhibiting the Proliferation of Human Colon Cancer: Pharmacokinetics and In Vivo Evaluation. Polymers. 15(3), 598, 2023.
118. Debjyoti Talukdar, Parveen Kumar, Benu Chaudhary, Deepak Sharma, Nishant Yadav, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I Alzarea, Imran Kazmi, Ashutosh Pareek, Gaurav Gupta, Madan Mohan Gupta. Biotransformation, multifunctional recycling mechanism of nanostructures, and evaluation of the safety of nanoscale materials. Particuology. 82, 76-86, 2023.
119. Imran Kazmi, Mohammad Arshad Javed Shaikh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I Alzarea, Fahad A Al-Abbasi, Manisha Pandey, Harish Dureja, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta. Chitosan-based nano drug delivery system for lung cancer. Journal of Drug Delivery Science and Technology. 81, 104196, 2023.
120. Obaid Afzal, Abdulamalik SA Altamimi, Mubarak A Alamri, Ali Altharawi, Manal A Alossaimi, Md Sayeed Akhtar, Fauzia Tabassum, Waleed H Almalki, Tanuja Singh. Resveratrol-Loaded Chia Seed Oil-Based Nanogel as an Anti-Inflammatory in Adjuvant-Induced Arthritis. Gels. 9(2), 131, 2023.
121. Asma B Omer, Obaid Afzal, Abdulmalik SA Altamimi, Shaktipal Patil, Shareefa A AlGhamdi, Amira M Alghamdi, Sami I Alzarea, Waleed Hassan Almalki, Imran Kazmi. Neuroprotective Effect of Barbaloin on Streptozotocin-Induced Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory Cytokines Pathway─TNF-α/IL-1β/IL-6/NF-κB. ACS Omega. 8(8), 8110–8118, 2023.
122. Mohammad Arshad Javed Shaikh, Gaurav Gupta, Obaid Afzal, Madan Mohan Gupta, Ahsas Goyal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi, Poonam Negi, Sachin Kumar Singh, Kamal Dua. Sodium alginate-based drug delivery for diabetes management: A review. International Journal of Biological Macromolecules. 236, 123986, 2023.
123. Handa M, Afzal O, Beg S, SanapNasik S, Kaundal RK, Verma RK, Shukla R. Harnessing personalized tailored medicines to digital-based data-enriched edible pharmaceuticals. Drug Discovery Today. 2023, 28(5), 103555.
124. Afzal O, Rizwanullah M, Altamimi AS, Alossaimi MA, Kamal M, Ahmad J. Harnessing natural polysaccharides-based nanoparticles for oral delivery of phytochemicals: Knocking down the barriers. Journal of Drug Delivery Science and Technology. 2023 Mar 16:104368.
125. Hussain A, Afzal O, Yasmin S, Haider N, Altamimi AS, Martinez F, Acree Jr WE, Ramzan M. Preferential Solvation Study of Rosuvastatin in the {PEG400 (1) + Water (2)} Cosolvent Mixture and GastroPlus Software-Based In Vivo Predictions. ACS omega. 2023 Mar 28;8(14):12761-72.
126. Thapa R, Afzal O, Altamimi AS, Goyal A, Almalki WH, Alzarea SI, Kazmi I, Jakhmola V, Singh SK, Dua K, Gilhotra R. Galangin as an inflammatory response modulator: An updated overview and therapeutic potential. Chemico-Biological Interactions. 2023 Apr 10:110482.
127. AlGhamdi SA, Al-Abbasi FA, Alghamdi AM, Omer AB, Afzal O, Altamimi AS, Alamri A, Alzarea SI, Almalki WH, Kazmi I. Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels. Royal Society Open Science. 2023, 10(4):230013.
128. Ashique S, Afzal O, Hussain A, Zeyaullah M, Altamimi MA, Mishra N, Ahmad MF, Dua K, Altamimi AS, Anand K. It's all about plant derived natural phytoconstituents and phytonanomedicine to control skin cancer. Journal of Drug Delivery Science and Technology. 2023, 84, 104495.
129. Panda SS, Afzal O, Altamimi AS, Beg S. Simultaneous estimation of neratinib and naringenin from pharmaceuticals using a stability-indicating liquid chromatographic method: Application to analytical quality by design concept and multi-tool method greenness assessment. Microchemical Journal. 2023, 191, 108848.
130. Bhat AA, Thapa R, Afzal O, Agrawal N, Almalki WH, Kazmi I, Alzarea SI, Altamimi AS, Prasher P, Singh SK, Dua K. The pyroptotic role of Caspase-3/GSDME signalling pathway among various cancer: A Review. International Journal of Biological Macromolecules. 2023, 242(2), 124832.
131. Ahsan MJ, Ali A, Ali A, Afzal O, Yusuf M, Altamimi AS, Sharma O, Alossaimi MA, Bakht MA. Synthesis of New 4′-(Substituted phenyl)spiro[indoline-3,3′-[1,2,4] triazolidine]-2,5′-diones as Antimicrobial, Antitubercular, and Antifungal Agents: An Insight into the ADME and Toxicity Prediction as well as in-silico Molecular Docking Studies. Journal of Molecular Structure. 2023 Oct 15;1290:135846.
132. Shaikh MA, Afzal O, Kazmi I, Alzarea SI, Jafar M, Altamimi AS, Jakhmola V, Anand K, Singh SK, Dua K, Gupta G. Harnessing chitosan-adorned liposomes for enhanced drug delivery in cancer. Journal of Drug Delivery Science and Technology. 2023, 85, 104619.
133. Mir Najib Ullah SN, Afzal O, Altamimi AS, Ather H, Sultana S, Almalki WH, Bharti P, Sahoo A, Dwivedi K, Khan G, Sultana S. Nanomedicine in the Management of Alzheimer’s Disease: State-of-the-Art. Biomedicines. 2023 Jun 18;11(6):1752.
134. Alam MN, Singh L, Khan NA, Asiri YI, Hassan MZ, Afzal O, Altamimi ASA, Hussain MS. Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ-Induced Kindled Epilepsy in Rats: In Vivo and In Silico. Pharmaceuticals. 2023 Aug 30;16(9):1223.
135. Virmani T, Kumar G, Sharma A, Pathak K, Akhtar MS, Afzal O, Altamimi AS. Amelioration of cancer employing chitosan, its derivatives, and chitosan-based nanoparticles: Recent updates. Polymers. 2023 Jul 1;15(13):2928.
136. Sharma AK, Bisht P, Gupta B, Akhtar MS, Alavudeen SS, Afzal O, Altamimi AS. Investigating miRNA subfamilies: can they assist in the early diagnosis of acute myocardial infarction? Drug Discovery Today. 2023, 28(10), 103695.
137. Ashique S, Afzal O, Khalid M, Ahmad MF, Upadhyay A, Kumar S, Garg A, Ramzan M, Hussain A, Altamimi MA, Altamimi AS. Biogenic nanoparticles from waste fruit peels: Synthesis, applications, challenges and future perspectives. International Journal of Pharmaceutics. 2023 Aug 25;643:123223.
138. Ashique S, Faiyazuddin M, Afzal O, Gowri S, Hussain A, Mishra N, Garg A, Maqsood S, Akhtar MS, Altamimi AS. Advanced nanoparticles, the hallmark of targeted drug delivery for osteosarcoma-an updated review. Journal of Drug Delivery Science and Technology. 2023, 87, 104753.
139. Agarwal M, Afzal O, Salahuddin, Altamimi AS, Alamri MA, Alossaimi MA, Sharma V, Ahsan MJ. Design, Synthesis, ADME, and Anticancer Studies of Newer N-Aryl-5-(3, 4, 5-Trifluorophenyl)-1, 3, 4-Oxadiazol-2-Amines: An Insight into Experimental and Theoretical Investigations. ACS omega. 2023 Jul 20;8(30):26837-49.
140. Ahmad I, Farheen M, Kukreti A, Afzal O, Akhter MH, Chitme H, Visht S, Altamimi AS, Alossaimi MA, Alsulami ER, Jaremko M. Natural Oils Enhance the Topical Delivery of Ketoconazole by Nanoemulgel for Fungal Infections. ACS omega. 2023 Jul 26;8(31):28233-48.
141. Thapa R, Ali H, Afzal O, Bhat AA, Almalki WH, Alzarea SI, Kazmi I, Altamimi AS, Jain N, Pandey M, Fuloria NK. Unlocking the potential of mesoporous silica nanoparticles in breast cancer treatment. Journal of Nanoparticle Research. 2023 Aug;25(8):169.
142. Thapa R, Afzal O, Kumar G, Bhat AA, Almalki WH, Alzarea SI, Kazmi I, Altamimi AS, Subramaniyan V, Thangavelu L, Singh SK. Unveiling the connection: long-chain non-coding RNAs and critical signaling pathways in breast cancer. Pathology-Research and Practice. 2023, 249, 154736.
143. Hussain MS, Afzal O, Kumar G, Altamimi AS, Almalki WH, Alzarea SI, Kazmi I, Fuloria NK, Sekar M, Meenakshi DU, Thangavelu L. Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling. Pathology-Research and Practice. 2023,249, 154738.
144. Adnan M, Akhter MH, Afzal O, Altamimi AS, Ahmad I, Alossaimi MA, Jaremko M, Emwas AH, Haider T, Haider MF. Exploring Nanocarriers as Treatment Modalities for Skin Cancer. Molecules. 2023 Aug 5;28(15):5905.
145. Afzal O, Ali A, Ali A, Altamimi AS, Alossaimi MA, Bakht MA, Salahuddin, Alamri MA, Ahsan MF, Ahsan MJ. Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1, 3, 4-oxadiazol-2-yl) amino) phenol Analogues: An Insight into Experimental and Theoretical Studies. Molecules. 2023 Aug 16;28(16):6086.
146. Dwivedi K, Mandal AK, Afzal O, Altamimi AS, Sahoo A, Alossaimi MA, Almalki WH, Alzahrani A, Barkat MA, Almeleebia TM, Mir Najib Ullah SN. Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders. Gels. 2023 Aug 18;9(8):671.
147. Hussain MS, Afzal O, Gupta G, Altamimi AS, Almalki WH, Alzarea SI, Kazmi I, Kukreti N, Gupta S, Sulakhiya K, Singh SK. Probing the Links: Long Non-Coding RNAs and NF-κB Signalling in Atherosclerosis. Pathology-Research and Practice. 2023, 249, 154773.
148. Keshwania P, Kaur N, Chauhan J, Sharma G, Afzal O, Alfawaz Altamimi AS, Almalki WH. Superficial Dermatophytosis across the World’s Populations: Potential Benefits from Nanocarrier-Based Therapies and Rising Challenges. ACS omega. 2023, 8(35), 31575–31599.
149. Hussain A, Ashique S, Hassan MZ, Afzal O, Yasiri YI, Kumar P, Dua K, Webster TJ, Altamimi AS, Altamimi MA. Pharmaceutical contaminants in aquatic systems, conventional and green strategies, recent updates, challenges and policies, and potential outcomes. Journal of Molecular Liquids. 2023, 389, 122905.
150. Hussain A, Altamimi MA, Afzal O, Altamimi AS, Ramzan M, Khuroo T. Mechanistic of Vesicular Ethosomes and Elastic Liposomes on Permeation Profiles of Acyclovir across Artificial Membrane, Human Cultured EpiDerm, and Rat Skin: In Vitro-Ex Vivo Study. Pharmaceutics. 2023 Aug 24;15(9):2189.
151. Abou-Taleb HA, Aldosari BN, Zaki RM, Afzal O, Tulbah AS, Shahataa MG, Abo El-Ela FI, Salem HF, Fouad AG. Formulation and Therapeutic Evaluation of Isoxsuprine-Loaded Nanoparticles against Diabetes-Associated Stroke. Pharmaceutics. 2023 Aug 30;15(9):2242.
152. Najib Ullah SN, Afzal O, Altamimi AS, Alossaimi MA, Almalki WH, Alzahrani A, Barkat MA, Almeleebia TM, Alshareef H, Shorog EM, Khan G. Bedaquiline-Loaded Solid Lipid Nanoparticles Drug Delivery in the Management of Non-Small-Cell Lung Cancer (NSCLC). Pharmaceuticals. 2023 Sep 15;16(9):1309.
153. Hussain A, Ashique S, Afzal O, Altamimi MA, Malik A, Kumar S, Garg A, Sharma N, Farid A, Khan T, Altamimi AS. A correlation between oxidative stress and diabetic retinopathy: An updated review. Experimental Eye Research. 2023, 236, 109650.
154. Bhat AA, Afzal O, Agrawal N, Thapa R, Almalki WH, Kazmi I, Alzarea SI, Altamimi AS, Kukreti N, Chakraborty A, Singh SK. A comprehensive review on the emerging role of long non-coding RNAs in the regulation of NF-κB signaling in inflammatory lung diseases. International Journal of Biological Macromolecules. 2023, 253(4), 126951.
155. Beg S, Afzal O, Kazmi I, Alkhathami AG, Ullah SN, Alshahrani MY, Almujri SS, Almalki WH, Altamimi AS, Alzahrani A, Al-Abbasi FA. Natural microbial surfactant containing self-nanoemulsifying formulation with improved performance of paclitaxel therapy: A newer avenue in breast cancer treatment. Journal of Drug Delivery Science and Technology. 2023, 90, 105105.
156. Mir MA, Akhter MH, Afzal O, Rab SO, Altamimi AS, Alossaimi MA, Nasar Mir Najib Ullah S, Jaremko M, Emwas AH, Ahmad S, Alam N. Design-of-Experiment-Assisted Fabrication of Biodegradable Polymeric Nanoparticles: In Vitro Characterization, Biological Activity, and In Vivo Assessment. ACS Omega, 2023, 8(42), 38806–38821.
157. Husain A, Monga J, Narwal S, Singh G, Rashid M, Afzal O, Alatawi A, Almadani NM. Prodrug Rewards in Medicinal Chemistry: An Advance and Challenges Approach for Drug Designing. Chemistry & Biodiversity. 2023, 20(11), e202301169.
158. Thapa R, Afzal O, Bhat AA, Goyal A, Alfawaz Altamimi AS, Almalki WH, Alzarea SI, Kazmi I, Singh SK, Dua K, Thangavelu L. New horizons in lung cancer management through ATR/CHK1 pathway modulation. Future medicinal chemistry. 2023, 15(19), 1807-1818.
159. Rahman M, Afzal O, Ullah SN, Alshahrani MY, Alkhathami AG, Altamimi AS, Almujri SS, Almalki WH, Shorog EM, Alossaimi MA, Mandal AK. Nanomedicine-Based Drug-Targeting in Breast Cancer: Pharmacokinetics, Clinical Progress, and Challenges. ACS omega. 2023, 8(51), 48625–48649.
160. Akhter MH, Al-Keridis LA, Saeed M, Khalilullah H, Rab SO, Aljadaan A, Rahman MA, Jaremko M, Emwas AH, Ahmad S, Alam N, Ali MS, Khan G, Afzal O. Enhanced Drug Delivery and Wound Healing Potential of Berberine-loaded Chitosan/Alginate Nanocomposite Gel: Characterization and in vivo Assessment. Frontiers in Public Health. 2023, 11, 1238961.
161. Afzal O, Ahsan MJ. An Efficient Synthesis of 1-(1, 3-Dioxoisoindolin-2-yl)-3-aryl Urea Analogs as Anticancer and Antioxidant Agents: An Insight into Experimental and In Silico Studies. Molecules. 2024, 29(1):67.
162. Hussain MS, Afzal O, Gupta G, Goyal A, Almalki WH, Kazmi I, Alzarea SI, Altamimi AS, Kukreti N, Chakraborty A, Singh SK. Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review. EXCLI Journal. 2024, 23, 34-52.
163. Bhat AA, Afzal O, Afzal M, Gupta G, Thapa R, Ali H, Kazmi I, Alzarea SI, Saleem S, Samuel VP, Gubbiyappa SK. MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting. Pathology-Research and Practice. 2024, 253, 154991.
164. Mahmoud DM, Ali MR, Aldosari BN, Zaki RM, Afzal O, Tulbah AS, Naguib DM, Zanaty MI, Attia ME, El-Ela FI, Fouad AG. Functional candesartan loaded lipid nanoparticles for the control of diabetes-associated stroke: In vitro and in vivo studies. International Journal of Pharmaceutics: X. 2024, 7, 100227.
165. Thapa R, Afzal O, Afzal M, Gupta G, Bhat AA, Kazmi I, Alzarea SI, Saleem S, Arora P, Singh SK, Dua K. From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression. Pathology-Research and Practice. 2024, 253, 154959.
166. Rahman M, Afzal O, Ullah SN, Alshahrani MY, Alkhathami AG, Sahoo A, Altamimi AS, Almalki WH, Almujri SS, Alotaibi AR, Alossaimi MA. Nanocarriers for delivering nucleic acids and chemotherapeutic agents as combinational approach: Challenges, clinical progress, and unmet needs. Journal of Drug Delivery Science and Technology. 2024, 92, 105326.
167. Vyas PJ, Wagh SS, Kalaskar MG, Patil KR, Sharma AK, Kazmi I, Al-Abbasi FA, Alzarea SI, Afzal O, AS AA, Gupta G. Volatile oil containing plants as phytopharmaceuticals to treat psöriasis: A Review. Current Pharmaceutical Biotechnology. 2024, 25(3), 313-339.
168. Kumar P, Yadav N, Chaudhary B, Umakanthan S, Chattu VK, Kazmi I, Al-Abbasi FA, Alzarea SI, Afzal O, AS AA, Gupta G. Lipid Nanocapsule: A Novel Approach to Drug Delivery System Formulation Development. Current Pharmaceutical Biotechnology. 2024, 25(3), 268-284.
169. Alharbi KS, Almalki WH, Alzarea SI, Kazmi I, Al-Abbasi FA, Afzal O, Altamimi AS, Albratty M, Najmi A, Gupta G. Anaesthesia-induced Changes in Genomic Expression Leading to Neurodegeneration. CNS & Neurological Disorders-Drug Targets, 2024, 23(4), 411-419.
170. Alamri MA, Afzal O, Akhtar MJ, Karim S, Husain M, Alossaimi MA, Riadi Y. Synthesis, in silico and in vitro studies of novel quinazolinone derivatives as potential SARS-CoV-2 3CLpro inhibitors. Arabian Journal of Chemistry. 2024, 17(1), 105384.
171. Alossaimi MA, Riadi Y, Alnuwaybit GN, Md S, Alkreathy HM, Elekhnawy E, Geesi MH, Alqahtani SM, Afzal O. Design, synthesis, molecular docking, and in vitro studies of 2-mercaptoquinazolin-4(3H)-ones as potential anti-breast cancer agents. Saudi Pharmaceutical Journal. 2024, 32(3), 101971.
172. Sarma K, Akther MH, Ahmad I, Afzal O, Altamimi ASA, Alossaimi MA, Jaremko M, Emwas AH, Gautam P. Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer. Molecules. 2024, 29(5), 1076.

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