أعضاء هيئة التدريس | مواقع أعضاء هيئة التدريس

د.احمد عادل عاشور محمد

أستاذ مشارك كلية الصيدلة بالخرج

الخرج
011-588-8888
ahmed.mohamed@psau.edu.sa

السيرة الذاتية
الأبحاث العلمية

المؤهلات العلمية

PhD: Faculty of Pharmacy, Mansoura University (Egypt)- Kyushu University (Japan) 2014 M.Sc.: Faculty of Pharmacy, Mansoura University 2010 B.Sc.: Faculty of Pharmacy, Mansoura University May 2007

الاهتمامات البحثية

Natural product chemistry; natural functional foods; bioactivity; Structure elucidation
Biotransformation of medicinal plant wastes into valuable chemicals and pharmaceuticals using two stage fermentation protocol.

الأبحاث العلمية

1- Amer, M., El-Sharkawy, S., Marzouk, A., Ashour, A.; “Chemical Constituents of Corncobs” Journal of Environmental Science, 40 (2), 251-258 (2011)
2- Amer, M., El-Sharkawy, S., Abdel Bar, F., Ashour, A.; “Phytochemical investigation of unused parts of Hibiscus Sabdariffa” Journal of American Science, 8 (12), 29-35 (2012).
3- Ashour, A., El-Sharkawy, S., Amer, M., Abdel Bar, F., Mera, A., Nagata, T., Kondo, R., Shimizu, K.; “Biotransformation of khellin to khellol by Aspergillus niger and the Evaluation of their Biological activities” The Open Bioactive Compounds Journal, 4, 1-3 (2013)
4- Ashour, A., El-Sharkawy, S., Amer, M., Abdel Bar, F., Kondo, R., Shimizu, K.; “Melanin Biosynthesis Inhibitory Activity of Compounds Isolated from unused parts of Ammi visinaga” Journal of Cosmetics, Dermatological Sciences and Application, 3 (3B), 40-43 (2013).
5- Ashour, A., Amer, M., Marzouk, A., Shimizu, K., Kondo, K., El-Sharkawy, S.; “Corncobs as a Potential Source of Functional Chemicals” Molecules , 18 (11), 13823-13830 (2013).
6- Ashour, A., El-Sharkawy, S., Amer, M., Abdel Bar, F., Katakura, Y., Miyamoto, T., Toyota, N., Hai Bang, T., Kondo, R., Shimizu, K.; “Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti-cancer drugs” Bioorganic and Medicinal Chemistry, 22 (1), 211-220 (2014).
7- Ashour, A., El-Sharkawy, S., Amer, M., Marzouk, A., Awad, A., Kishikawa, A., Ohzono, M., Kondo, K., Shimizu, K.; “Production of citric acid from Corn cobs with its biological evulation” Journal of Cosmetics, Dermatological Sciences and Application, 4 (3), 141-149 (2014).
8- Tan, H., Ashour, A., Katakura, Y., Shimizu, K.; “A structure-activity relationship study on antiosteoclastogenesis effect of triterpenoids from the leaves of loquat (Eriobotrya japonica) ” Phytomedicine, 22, 498-503 (2015).
9- Kishikawa, A., Ashour, A., Zhu, Q., Yasuda, M., Ishikawa, H., Shimizu, K.; “Multiple biological effects of olive oil by-products such as leaves, stems, flowers, olive milled waste, fruit pulp, and seeds of the olive plant on skin” Phytotherpary Research, 29, 877-886 (2015).
10- Zaki, A., Ashour, A., Mira, A., Kishikawa, A., Nakagawa, T., Zhu, Q., Shimizu, K.; “ Biological activities of oleanolic acid derivatives from Calendula officinalis seeds” Phytotherpary Research, 30 (5), 835-841(2016).
11- Amen, Y., Zhu, Q., Hai Bang, T., Afifi, M., Halim, A., Ashour, A., Mira, A., Shimizu, K.; “ Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells” Journal of Natural Medicines, 70, 661-666 (2016).
12- Amen, Y., Zhu Q., Afifi, M., Halim, A., Ashour, A., Shimizu, K.; “New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi ” Phytochemistry letter, 17, 64-70 (2016).
13- Elbermawi, A., Sallam, A., Ashour, A., Ebrahim, W., Lahloub, M., Saa, H.; “Biologically Active Metabolites from Penicillium sp., An Endophyte Isolated from Glaucium arabicum” Journal of American Science, 12, 33-41 (2016).
14- Sallam, A., Mira, A., Ashour, A., Shimizu, K.; “ Acetyl choline esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis” Phytomedicine, 23 (10), 1005-1011 (2016).
15- Horiba, H., Nakagawa, T., Zhu, Q., Ashour, A., Watanabe, A., Shimizu, K.; “Biological Activities of Extracts from Different Parts of Cryptomeria japonica” Natural Product Communication, 11(9), 1337-1342 (2016).
16- Amen, Y., Zhu, Q., Tran, H., Afifi, M., Halim, A., Ashour, A., Shimizu, K.; “Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors” Journal of Natural Medicines, 71 (2), 380-388 (2017)
17- Amen, Y., Arung, E., Afifi, M., Halim, A., Ashour, A., Fujimoto, R., Goto, T., Shimizu, K.; “Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells” Natural Product Research, 31 (23), 2712-2718 (2017).
18- Lahloub, M.F., Amer, M., Zaki, A., Ashour, A., Amen, Y., Samara, R.; “Bioactive compounds from Malva rotundifolia L.” World Journal of Pharmaceutical Science, 5(8), 171-176 (2017).
19- Amen, Y., Arung, E., Afifi, M., Halim, A., Ashour, A., Shimizu, K.; “Rho-kinase inhibitors from Adlay seeds” Natural Product Research, 32 (16), 1955-1959 (2018).
20- Satria, D., Amen, Y., Niwa, Y., Ashour, A., Allam, A., Shimizu, K., “Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)” Natural Product Research, 33 (2), 189-195 (2018).
21- Taga, Y., Hayashida, O., Ashour, A., Amen, Y., Kusubata, M., Ogawa-Goto, K., Shimizu, k., Hattori, S.; “Characterization of Angiotensin-Converting Enzyme Inhibitory Activity of X-Hyp-Gly-Type Tripeptides: Importance of Collagen-Specific Prolyl Hydroxylation” Journal of Agricultural and Food Chemistry, 66 (33), 8737-8743 (2018).
22- Ashour, A., Amen, Y., Nakagawa, T., Niwa, Y., Mira, A., Ohnuki, K., Murakami, S., Imao, M., Shimizu, K.; “A New aliphatic ester of hydroxy salicyclic acid from fermented Carica papaya L. preparation with a potential hair growth stimulating activity” Natural Product Research, Accepted (2018).
23- Nakagawa, T., Ashour, A., Amen, Y., Ohnuki, K., Fujimoto, N., Shimizu, K.; “Antioxidant and anti-lipase compounds isolated from heartwood of Yakushima native cedar (Cryptomeria japonica)” Journal of Wood Chemistry and Technology, Accepted (2019).
24- Ashour, A., Amen, Y., Allam, A., Kudo, T., Nagata, M., Ohnuki, K., Shimizu, K.; “New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus” Phytochemistry letters, 32, 10-14 (2019).
25- Elbermawi, A., Halim, A., Mansour, E., Ahmad, K., Ashour, A., Amen, Y., Shimizu, K.; “A new glucoside with a potent α-glucosidase inhibitory activity from Lycium schweinfurthii” Natural Product Research, Accepted (2019).
26- Mwakalukwa, R., Ashour, A., Amen, Y., Niwa, Y., Tamrakar, S., Miyamoto, T., Shimizu, K.; “Anti-allergic activity of polyphenolic compounds isolated from olive mill wastes” Journal of Functional Foods, 58, 207-217 (2019).
27- Nakagawa, T., Ashour, A., Amen, Y., Koba, Y., Ohnuki, K., and Shimizu, K.; “α-Glucosidase inhibitory activity of resin from Sakhalin fir tree (Abies sachalinensis) and its bioactive compounds” Natural Product Communication, 1-4 (2019).
28- Abdelkarem, F., Desoky, E., Nafady, A., Allam, A., Mahdy, A., Ashour, A., Mohamed, G., Miyamoto, T., Shimizu, K.; “Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae)” Natural Product Research, 35 (2), 236-243 (2021).
29- Elkattan, A., Gohar, A., Amer, M., Naeem, Z., Ashour, A., Shimizu, K.; “Melanin Synthesis inhibitors from Olea europeae” Records of Natural Products, Accepted (2019)
30- Zaki, A., Ashour, A., Qiu, L.; “New sesquiterpene glycoside ester with antiprotozoal activity from the flowers of Calendula officinalis L” Natural Product Research, Accepted (2020).
31- Hassan, A., Ashour, A., Amen, Y., Nagata, M., El-Toumy, S., Shimizu, K.; “A new cycloartane triterpene and other phytoconstituents from the aerial parts of Euphorbia dendroides” Natural Product Research, Accepted (2020).
32- Shams, A., Soliman, A., Ashour, A., Marzouk, A, El-Sharkawy, S.; “Utilization of Wood Industrial Wastes for Production of Chemicals and Pharmaceuticals” Indian Journal of Science and Technology, Accepted (2020).
33- Zaki, A., Al‐Karmalawy, A., El-Amier, Y., Ashour, A.; “Molecular docking reveals the potential of Cleome amblyocarpa isolated compounds to inhibit COVID-19 virus main protease” New Journal of Chemistry, 44, 16752-16758 (2020).
34- Abdelkarem, F., Desoky, E., Nafady, A., Allam, A., Mahdy, A., Ashour, A., Shimizu, K.; “Diadema setosum: Isolation of bioactive secondary metabolites with cytotoxic activity toward human cervical cancer” Natural Product Research, Accepted (2020).
35- Samra, R., Soliman, A., Zaki, A., Ashour, A., Al‐Karmalawy, A., Hassan, M., Zaghloul, A.; “Bioassay-guided isolation of a new cytotoxic Ceramide from Cyperus rotundus L.” South African Journal of Botany, Accepted (2021).
36- Elbermawi, A., Halim, A., Mansour, E., Ahmad, K., Elsbaey, M., Ashour, A., Amen, Y., El-Gamil, M., Miyamoto, T., Shimizu, K.; “Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities” Natural Product Research, Accepted (2021).
37- Zaki, A., Ashour, A., Elhady, S., Darwish, K., Al‐Karmalawy, A.; “Calendulaglycoside A Showing Potential Activity Against SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and SAR Studies” journal of traditional and complementary medicine, Accepted (2021).
38- Allam, A., Amen, Y., Ashour, A., Assaf, H., Hassan, H., Mohamed, I., Sayed, A., Shimizu, K.; “In silico study of natural compounds from Sesame against COVID-19 by targeting Mpro, PLpro and RdRp” RSC advances, Accepted (2021).
39- Zaki, A., Al‐Karmalawy, A., Khodir, A., El-Amier, Y., Ashour, A.; “Isolation of cytotoxic active compounds from Reichardia tingitana with investigation of apoptosis mechanistic induction: in silico, in vitro, and SAR studies” South African Journal of Botany, 144, 115-123 (2022).
40- Zaki, A., Kaddah, M., Abulkhair, H., Ashour, A.; “Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from Panicum turgidum” RSC advances, Accepted (2022).
41- Zaki, A., El-Amier, Y., Ashour, A.; “Two new cytotoxic tetralin derivatives from Panicum turgidum” Natural Product Research, Accepted (2022).
42- Saleh, M., Antar, S., Abdo, W., Ashour, A., Zaki, A.; “Genistin Modulates High-Mobility Group Box Protein 1 (HMGB1) and Nuclear Factor kappa-B (NF-κB) in Ehrlich-Ascites-Carcinoma-Bearing Mice” Environmental Science and Pollution Research, Accepted (2022).
43- Elbermawi, A., Ali, A., Amen, Y., Ashour, A., Ahmad, K., Mansour, E., Halim, A.; “Anti-diabetic activities of phenolic compounds of Alternaria sp. an endophyte isolated from the leaves of desert plants growing in Egypt” RSC advances, Accepted (2022).
44- Ashour, A., Elbermawi, A., Amen, Y., Allam, A., Ikeda, H., Nagata, M., Kumagae, K., Azuma, T., Taguchi, A., Takemoto, T., Matsumoto, M., Shimizu, K.; “Melanin synthesis inhibition activity of compounds isolated from Bamboo shoot skin (Phyllostachys pubescens)” Molecules, 28 (1), 1-12 (2023).
45- Ali, A., Makki, A., Ibraheem, W., Abdelrahman, M., Osman, W., Sherif, A., Ashour, A., Ibrahim, S., Ghazawi, K., Samman, W., Alzain, A.; “Design of Novel Phosphoinositol 3-kinase Inhibitors for Non-Hodgkin’s Lymphoma: Molecular Docking, Molecular Dynamics, and Density Functional Theory Studies on Gold Nanoparticle” Molecules, 28 (5), 1-19 (2023).
46- Edris, A., Abdelrahman, M., Osman, W., Sherif, A., Ashour, A., Garelnabi, E., Ibrahim, S., Bafail, R., Samman, W., Ghazawi, K., Mohamed, G., Alzain, A.; “Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theortical Studies on Gold Nanoparticle” Metabolites, 13 (583), 1-17 (2023).
47- Alzain, A., Mukhtar, R., Abdelmoniem, N., Elbadwi, F., Hussien, A., Garelnabi, E., Osman, W., Sherif, A., Khedr, A., Ghazawi, K., Samman, W., Ibrahim, S., Mohamed, G., Ashour, A., “Computational Insights into Natural Antischistosomal Metabolites as SmHDAC8 Inhibitors: Molecular Docking, ADMET Profiling, and Molecular Dynamics Simulation” Metabolites 13 (5), 1-16 (2023).
48- Mukhtar, R., Abdelmoniem, N., Elrufaie, H., Edris, A., Ghaboosh, H., Mahgoub, M., Garelnabi, E., Osman, W., Sherif, A., Ashour, A., Ghazawi, K., Samman, W., Alhaddad, A., Bafail, R., Ibrahim, S., Mohamed, G., Alzain, A.; “Unlocking the Potential of Approved Drugs for the Allosteric Inhibition of Tropomyosin-receptor Kinase A (TrkA) Using Molecular Docking and Molecular Dynamics Studies” Frontier in Chemistry, Accepted, 1-12 (2023).
49- Hussain, M., Mohamed, M., Altayb, H., Mohamed, A., Ashour, A., Osman, W., Sherif, A., Ghazawi, K., Miski, S., Ibrahim, S., Mohamed, G., Sindi, I., Alshamrani, A., Elgaml, A.; “Comparative Genomic Analysis of Multi-Drug Resistant Pseudomonas aeruginosa Sequence Type 235 Isolated from Sudan” Microorganisms 11(6), 1-17 (2023).
50- Hassan, M., Hussain, M., Ali, S., Mahdi, M., Mohamed, N., AbdElbagi, H., Mohamed, O., Sherif, A, Osman, W., Ibrahim, S., Ghazawi, K., Miski, S., Mohamed, G., Ashour, A.; “Detection of Nonsynonymous Single Variants in human HLA-DRB1 Exon 2 associated with renal transplant rejection” Medicina 59, 1-12 (2023).
51- Hussain, M., Hassan, M., Bashir, B., Gamar, T., Gasmalbari, E., Mohamed, A., Osman A., Sherif, A., Elgaml, A., Alhaddad, A., Ghazawi, K., Miski, S., Ainousah, B., Andijani, Y., Ibrahim, S., Mohamed, G., Ashour, A.; “Potential Therapeutic Target and Vaccines for SARS-CoV-2. Pathogens” Pathogens 12 (7), (2023) https://doi.org/10.3390/pathogens12070926
52- Shoaib, T., Ibraheem, W., Abdelrahman, M., Osman A., Sherif, A., Ashour, A., Ibrahim, S., Ghazawi, K., Miski, S., Almadani, S., Alsiyud, D., Mohamed, G., Alzain, A.; “Exploring the potential of approved drugs for triple-negative breast cancer treatment by targeting casein kinase 2: Insights from computational studies” PLOS ONE 18 (8), 2023. https://doi.org/10.1371/journal.pone.0289887
53- Elamin, E., Eshage, S., Mohmmode, S., Mukhtar, R., Mahjoub, M., Sadelin, E., Shoaib, T., Edris, A., Elshamly, E., Makki, A., Ashour, A., Sherif, A, Osman, W., Ibrahim, S., Mohamed, G., Alzain, A.; “Discovery of dual-target natural antimalarial agents against DHODH and PMT of Plasmodium falciparum: pharmacophore modelling, molecular docking, quantum mechanics, and molecular dynamics simulations” SAR and QSAR in Environmental Research, 2023, Accepted.
54- Shoiab, T., Almogaddam, M., Andijani, Y., Saib, S., Almaghrabi, N., Elyas, A., Azzouni, R., Awad, E., Mohamed, S., Mohamed, G., Ibrahim, S., Hussein, H., Osman, W., Ashour, A., Sherif, A., Alzain, A.; “Marine-Derived Compounds for CDK5 Inhibition in Cancer: Integrating Multi-Stage Virtual Screening, MM/GBSA Analysis and Molecular Dynamics Investigations” Metabolites 13 (10), 1-17 (2023).
55- Ashour, A., Sherif, A., El-Sayed, S., Kim, J., Jang, D., Anvari, A., Farahat, A., Ibrahim, S., Mohamed, G., Ainousah, B., Aljohani, R., Al-Hejaili, R., Khoja, R., Hassan, A., Zaki, A.; “Tetraenone A: A new β-ionone Derivative from Tetraena aegyptia” Metabolites 13 (12), 1-17 (2023).
56- Nabag, M., Osman, B., Abdoon, I, Osman, W., Sherif, A., Khedr, A., Ibrahim, S., Mohamed, G., Ghazawi, K., Mohamed, S., Hussein, H., Ashour, A., “Antinociceptive and Analgesic Activities of Asparagus Flagellaris (Kunth) Baker, Tephrosia Uniflora Pers., and Acacia Gerrardii Benth” Egyptian Journal of Chemistry 66 (13), 1645-1656 (2023).
57- Osman, W., Maaz, M., Ali, A., Fadul, E., Arbab, A., Al-Nour, M., Ashour, A., Sherif, A., Abulkhair, H., Ibrahim, S., Ghazawi, K., Mohamed, G., Mohamed, M., “Geigeria Alata-Apotential source for Anti-Alzheimer’s constituents: In vitro and Computational investigations” Indonesian Journal of Pharmacy 34(4), 602-615 (2023).
58- Antar, S., Ashour, A., Abdo, W., Khodir, A., Sherif, A., Qiu, L., Zaki, A. “Anti-tumor effects of Soyasaponin IV as a natural product in Ehrlich ascites carcinoma bearing mice: modulation of monocyte vascular endothelial growth factor (VEFG) and nuclear factor kappa B (NF-κB) pathways” Arab Journal of Basic and Applied Sciences 31(1), 71-82 (2024).
59- Osman, W., Mirghani, M., Mohamed, M., Sherif, A., Ashour, A., Sweilam, S., Subki, H. “Chromatographical fingerprint analysis, in silico investigation and identification of hepatoprotective active compounds from Capparis decidua Edgwe (Forssk.)” Journal of Applied Pharmaceutical Sciences, 14 (8), 112-124, 2024 (Accepted).
60- Alzain, A., Elbadwi, F., Shoaib, T., Sherif, A., Osman, W., Ashour, A., Mohamed, G., Ibrahim, S., Roh, E., Hassan, A. “Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studies” Frontier in Chemistry 12, 1-14 (2024).
61- Abdelkarim, O., Abubakar, U., Hussain, M., Abadi, A., Mohamed, A., Osman, W., Sherif, A., Ebrahim, S., Ahmed, A., Ahmed, M., Ashour, A. “Knowledge, Perception, and Self-Confidence of Antibiotic Resistance, Appropriate Antibiotic Therapy, and Antibiotic Stewardship Among Undergraduate Pharmacy Students in Sudan” Infection and Drug Resistance 17, 935-949 (2024).
62- Ainousah, B., Ibrahim, S., Alzain, A., Mohamed, S., Hussein, H., Ashour, A., Abdallah, H., Mohamed, G. “Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties” Archives of Microbiology, 206-216 (2024).
63- Ashour, A., Samra, R., Darwish, M., Abou-Zeid, N., Zaki, A. “Antidiabetic and prebiotic activities of flavonoids from Cyperus conglomeratus rottb” Biochemical Systematic and Ecology, 116, 1-7 (2024).
64- Elkattan, A., Matsumoto, M., Nagata, M., Mittraphab, Y., Abdel Wahab, G., Ashour, A., Zaki, A., Hamed, E., Shimizu, K. “Isolation of holostane-type saponins from the black sea cucumber Holothuria atra and evaluating their anti-allergic activity: in vitro and in silico study” Cytotechnology, 2024 (Accepted).
65- Ashour, A., Amen, Y., Allam, A., Mwakalukwa, R., Niwa, Y., Shimizu, K. “The peels of sacred Lotus (Nelumbo nucifera) rhizomes suppress allergic reactions by inhibiting the A23187-induced degranulation in rat basophilic leukemia (RBL 2H3) cells” Fitoteropia, 178, 1-7, 2024 (Accepted).
66- Osman, W., Shantier, S., Mohamed, N., Abdalla, S., Mohamed, M., Umar, Y., Sherif, A., Elamin, K., Ashour, A., “Prediction of ADMET, molecular docking, DFT, and QSPR of potential phytoconstituents from Ambrosia maritima L. targeting xanthine oxidase” Pharmacia, 71, 1-10, 2024 (Accepted).
67- Gibreel, H., Kordofani, M., Warrag, E., Ashour, A., Sherif, A., Osman, W., Ibrahim, S., Mohamed, G., Sindi, I., Abulkhair, H., Mohamed, M. “A Taxonomic analysis of the Sudanese medicinal plant, Vachellia nilotica L. (Syn: Acacia nilotica L.) based on pods, seeds, and vegetative traits” Pakistan Journal of Botany, 56 (4), 1507-1516, 2024.
68- Zhang, C., Zhang, B., Zhang, L., Ashour, A., Wang, Y., Zhang, Y., Tan, H., Li, L., Jiao, X. “Malvidin-3-O-galactoside ameliorates colonic mucosal barrier function via the Notch signaling pathway” Food Innovation and advances, 3 (3), 279-287, 2024.
69- Alwossabi, A., Elamin, E., Ahmed, E., Ismail, E., Ashour, A., Osman, W., Sherif, A., Mira, A., Bafail, R., Andijani, Y., Ibrahim, S., Mohamed, G., Abdelrahman, M. “Enhanced Oral Bioavailability and Stability Studies of Loratadine Tablets Based on Solid Dispersion of Modified Ziziphus spina-christi Gum” Recent advances in Drug Delivery and Formulation, 18 (3), 208-224, 2024.

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د.احمد عادل عاشور محمد

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مواقع أعضاء هيئة التدريس

د.احمد عادل عاشور محمد

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الأبحاث العلمية

إدارة العلاقات العامة والإعلام