Ansari MJ, Kohli K, Ali J, Anwer MK, Jamil S, Ahmad MM. Physicochemical characterizations and dissolution behavior of curcumin and α-cyclodextrin molecular inclusion complexes. Der Pharmacia Letter, 2014; 6(6):1-7. (Scopus H index 13).
The aim of present work was to enhance the aqueous solubility and dissolution rate of the curcumin, a water
insoluble yellow colored phenolic pigment with good anti-inflammatory property obtained from dried rhizomes of
plant Cucrcuma longa. This paper presents physicochemical evaluations of curcumin and its molecular inclusion
complexes with α-cyclodextrin. Phase solubility studies revealed linear relationships (AL type) indicating 1:1 ratios
of curcumin and α-cyclodextrin. Based upon the stoichiometric ratio as obtained from phase solubility studies, solid
inclusion complexes were prepared by grinding, kneading and freeze drying methods and then investigated by
differential scanning calorimetry (DSC), infra red spectroscopy (IR) and X-ray diffractometry (XRD). All tested
curcumin complexes behaved as amorphous solid mixture in XRD and FT IR investigations. Prepared inclusion
complexes were compared with pure curcumin for their dissolution behavior. Dissolution study revealed 10.5%
release of curcumin at 1 hour and a maximum of 40.9% release was obtained by the end of 6 hours, which was due
to poor water solubility of curcumin. In contrast, curcumin complexes demonstrated faster and better release
behaviors. At least 3 fold increases in dissolution of all tested complexes were observed at one hour as compared to
pure curcumin, with a maximum increase of approximately 3.5 fold as shown by kneaded and freeze dried
complexes. At the end of 6 hours, approximately 60-65% release was observed from all inclusion complexes with a
maximum release of 65% exhibited by freeze dried complex. Cyclodextrin complexation of curcumin enhanced
dissolution of practically insoluble curcumin.
Physicochemical characterizations and dissolution behavior of curcumin and α-cyclodextrin molecular
محتويات مواقع أعضاء هيئة التدريس بما فيها من نصوص وملفات وصور وأبحاث وأية مواد أخرى هي مسئولية عضو هيئة التدريس بالكامل بصفته صاحب الموقع وبما له من صلاحية مطلقة في الإضافة والحذف، وتخلي الجامعة مسئوليتها عن محتويات تلك المواقع.
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