Ansari MJ, M. Althubaiti, MO Ibnouf, MK Anwer, MM Ahmed, F Fatima, S Jamil. Enhanced Antibacterial Effects of Ciprofloxacin Enclosed In Cyclodextrin and Nano-Suspension Carrier Systems. Bulletin of Environment, Pharmacology and Life Sciences, 2015, 4(11):14-18. (ISI indexed).
This paper presents enhanced antimicrobial activities of ciprofloxacin when it was delivered through molecular inclusion complex system or nano-suspension carrier system. Ciprofloxacin is a broad spectrum second generation fluoroquinolone antibiotic which is effective against gram positive and gram negative bacteria. It kills bacteria by interfering
with topoisomerase which stops synthesis of DNA and of protein. It is practically insoluble in water and sensitive to sunlight losing its antibacterial activity. Objective of this research is to enhance solubility of ciprofloxacin so as to achieve better efficacy. Solubility enhancement of ciprofloxacin was achieved using a classical cyclodextrin inclusion complex and a current nanotechnology approach. Inclusion complexes were prepared with beta-cyclodextrin using kneading method.
Nanosuspension of ciprofloxacin was prepared by anti solvent precipitation method. Pure ciprofloxacin suspension and equivalent amount of nano-suspension and inclusion complexes were tested and compared for antibacterial activity using agar diffusion method against gram positive bacteria such as MRSA ATCC # 33591, B. subtilis ATCC # 10400, E. coli
ATCC # 13706, K. pneumoniae ATCC # 13368, P. aeruginosa ATCC # 27853. Observed zone of inhibition by all treatment were statistically analyzed to achieve a valid conclusion. Statistical significance was determined by one-way analysis of variance with p<0.05 considered as significant. All tested treatments were found effective against all tested strains. The statistical analysis revealed that there is significant difference (p<0.05) between pure ciprofloxacin and its formulations such as inclusion complex and nanosuspension however there was no significant difference between the formulations.
Enhanced Antibacterial Effects of Ciprofloxacin Enclosed In Cyclodextrin and Nano-Suspension Carrier
محتويات مواقع أعضاء هيئة التدريس بما فيها من نصوص وملفات وصور وأبحاث وأية مواد أخرى هي مسئولية عضو هيئة التدريس بالكامل بصفته صاحب الموقع وبما له من صلاحية مطلقة في الإضافة والحذف، وتخلي الجامعة مسئوليتها عن محتويات تلك المواقع.
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