FDA approves first absorbable stent for coronary artery disease

FDA approves first absorbable stent for coronary artery disease

July 5, 2016 -- The U.S. Food and Drug Administration today approved the first fully absorbable stent to treat coronary artery disease. The Absorb GT1 Bioresorbable Vascular Scaffold System (BVS), which releases the drug everolimus to limit the growth of scar tissue, is gradually absorbed by the body in approximately three years.

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published in: 2016-08-18 10:13:57

FDA Approves First Generic Version of Widely Used Influenza Drug Tamiflu

FDA Approves First Generic Version of Widely Used Influenza Drug Tamiflu

On August 3, 2016, the U.S. Food and Drug Administration approved the first generic version of Tamiflu (oseltamivir phosphate), a widely used medication for the treatment of the flu (influenza A and B) in patients two weeks of age and older who have had flu symptoms for no more than 48 hours; and prevention of the flu in patients one year of age and older. Tamiflu was approved in 1999. The FDA is committed to improving patient access to safe and effective generic drugs.

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published in: 2016-08-18 10:12:26

New analysis shows only minority of COPD patients may benefit from inhaled corticosteroids

New analysis shows only minority of COPD patients may benefit from inhaled corticosteroids

Boehringer Ingelheim has announced a new publication showing that levels of white blood cells called eosinophils can help identify patients with COPD who may and may not benefit from the addition of ICS treatment. (1) In WISDOM, for 80 percent of patients, the use of ICS on top of Spiriva® and a LABA had no additional benefit in reducing the risk of exacerbations or 'flare-ups,' compared to Spiriva® and a LABA without ICS. The post-hoc analysis shows that these patients can be easily identified by measuring the level of eosinophils in their blood. Patients with levels lower than 4 percent (300 cells/µL) had no additional exacerbation benefit with the inclusion of ICS in their regimen.

The 52-week, large-scale WISDOM study evaluated the effect of ICS withdrawal in patients with severe to very severe COPD with a history of exacerbation, while receiving Spiriva® and a LABA. This new post-hoc analysis from WISDOM found that the 20 percent of patients who benefited from a reduced exacerbation risk due to the continued use of ICS on top of a combination of Spiriva® with a LABA had higher levels of blood eosinophils (≥300 cells/µL; more than 4 percent).

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published in: 2016-04-14 10:29:51

Nanoparticles show promise for treating intestinal inflammation

Nanoparticles show promise for treating intestinal inflammation

Nanoparticles designed to block a cell-surface molecule that plays a key role in inflammation could be a safe treatment for inflammatory bowel disease (IBD), according to researchers in the Institute for Biomedical Sciences at Georgia State University and Southwest University in China.

The scientists developed nanoparticles, or microscopic particles, to reduce the expression of CD98, a glycoprotein that promotes inflammation. Their findings are published in the journal Colloids and Surfaces B: Biointerfaces.

"Our results suggest this nanoparticle could potentially be used as an efficient therapeutic treatment for inflammation," said Didier Merlin, professor in the Institute for Biomedical Sciences at Georgia State and researcher at the Atlanta Veterans Affairs Medical Center. "We targeted CD98 because we determined in a previous study that CD98 is highly over-expressed in activated immune cells involved in IBD."

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published in: 2016-04-10 11:03:14

World Health Day 7th April 2016

World Health Day  7th April 2016

The World Health Day is a global health awareness day celebrated every year on 7 April, under the sponsorship of the World Health Organization (WHO).

World Health Day is one of eight official global public health campaigns marked by WHO, along with World Tuberculosis DayWorld Immunization WeekWorld Malaria DayWorld No Tobacco DayWorld Blood Donor DayWorld Hepatitis Day, and published in: 2016-04-07 14:15:14

Vitamin D improves heart function, study finds

Vitamin D improves heart function, study finds

A daily dose of vitamin D3 improves heart function in people with chronic heart failure, a five-year University of Leeds research project has found. Dr Klaus Witte, from the School of Medicine and Consultant Cardiologist at Leeds Teaching Hospitals NHS Trust, led the study, known as VINDICATE.

He said: "This is a significant breakthrough for patients. It is the first evidence that vitamin D3 can improve heart function of people with heart muscle weakness - known as heart failure. These findings could make a significant difference to the care of heart failure patients."

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published in: 2016-04-06 10:05:09

Diabetes Medications Containing Saxagliptin and Alogliptin: Drug Safety Communication - Risk of Heart Failure

Diabetes Medications Containing Saxagliptin and Alogliptin: Drug Safety Communication - Risk of Heart Failure

ISSUE: An FDA safety review has found that type 2 diabetes medicines containing saxagliptin andalogliptin may increase the risk of heart failure, particularly in patients who already have heart or kidney disease. As a result, FDA is adding new warnings to the drug labels about this safety issue.

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published in: 2016-04-06 09:26:22

Common painkillers are more dangerous than we think

Common painkillers are more dangerous than we think

Many Danes are prescribed NSAIDs for the treatment of painful conditions, fever and inflammation. But the treatment also comes with side effects, including the risk of ulcers and increased blood pressure. A major new study now gathers all research in the area. This shows that arthritis medicine is particularly dangerous for heart patients, and also that older types of arthritis medicine, which have not previously been in focus, also appear to be dangerous for the heart.

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published in: 2016-04-04 00:46:26

Nanoparticle-based cancer therapies shown to work in humans

Nanoparticle-based cancer therapies shown to work in humans

A team of researchers led by Caltech scientists have shown that nanoparticles can function to target tumors while avoiding adjacent healthy tissue in human cancer patients.

In the study, Davis and his colleagues examined gastric tumors from nine human patients both before and after infusion with a drug - camptothecin - that was chemically bound to nanoparticles about 30 nanometers in size.

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published in: 2016-04-04 00:37:00

FRAUD IN CLINICAL TRIALS SAYS US FDA

FRAUD IN CLINICAL TRIALS SAYS US FDA

One of the most important responsibilities of the Food and Drug Administration (FDA) in protecting public health is to conduct regular inspections of clinical trial sites to ensure that good clinical practices are being followed. But a new study published in the peer-reviewed journal JAMA Internal Medicine has found that nearly half of all clinical trials are based on false information, and the FDA typically does nothing to address this widespread problem.

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published in: 2015-03-08 11:19:59