Development and evaluation of olmesartan medoxomil loaded PLGA nanoparticles. Materials Research Innovations, 2016; 20 (3): 193-197 (Impact Factor: 0.83). M. K. Anwer* 1 , S. Jamil 1 , M. J. Ansari 1 , M. Iqbal 2 , F. Imam 3 and F. Shakeel 4 Department of Pharmaceutics, college of pharmacy, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.
The purpose of the present study was to develop olmesartan medoxomil (OLM) loaded poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles by nanoprecipitation technique. Olmesartan medoxomil nanoparticles (F1–F3) were prepared using PLGA as polymer and Pluronic acid 127 as a surfactant. Developed PLGA nanoparticles were evaluated for particle size, polydispersity index (PI), differential scanning calorimetry (DSC), Fourier transforms infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy (SEM), drug entrapment efﬁciency (EE%) and in vitro drug release. Optimised PLGA nanoparticle (F3) had particle size of 97.8¡6.3 nm, EE of 58.33% and drug release of 37.1% after 24 h of study. SEM images conﬁrmed that developed nanoparticles were spherical in shape with a smooth surface. DSC, FTIR, and XRD spectra indicated formation of PLGA nanoparticles. The results suggest that PLGA polymer-based nanoparticle could be a potential option for sustained drug delivery of OLM.
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