Development and optimization of fluoxetine orally disintegrating tablets using Box-Behnken design. Tropical Journal of Pharmaceutical Research April 2016; 15 (4): 667-677. Bahaa E Ali1,2, Abdullah K Rabba3, Mohamed H Fayed1, Khalid M El-Say2,4, Mohammad Khalid Anwer1, Mohammad Javed Ansari1, Ramadan Al-Shdefat1, Gamal A Gabr5,6.
Purpose: To develop and optimize some variables that influence fluoxetine orally disintegrating tablets (ODTs) formulation.
Methods: Fluoxetine ODTs tablets were prepared using direct compression method. Three-factor, 3-level Box-Behnken design was used to optimize and develop fluoxetine ODT formulation. The design suggested 15 formulations of different lubricant concentration (X1), lubricant mixing time (X2), and compression force (X3) and then their effect was monitored on tablet weight (Y1), thickness (Y2), hardness (Y3), % friability (Y4), and disintegration time (Y5).
Results: All powder blends showed acceptable flow properties, ranging from good to excellent. The disintegration time (Y5) was affected directly by lubricant concentration (X1). Lubricant mixing time (X2) had a direct effect on tablet thickness (Y2) and hardness (Y3), while compression force (X3) had a direct impact on tablet hardness (Y3), % friability (Y4) and disintegration time (Y5). Accordingly, Box-Behnken design suggested an optimized formula of 0.86 mg (X1), 15.3 min (X2), and 10.6 KN (X3). Finally, the prediction error percentage responses of Y1, Y2, Y3, Y4, and Y5 were 0.31, 0.52, 2.13, 3.92 and 3.75 %, respectively. Formula 4 and 8 achieved 90 % of drug release within the first 5 min of dissolution test.
Conclusion: Fluoxetine ODT formulation has been developed and optimized successfully using Box-Behnken design and has also been manufactured efficiently using direct compression technique.
Development and optimization of fluoxetine orally disintegrating tablets using Box-Behnken design.
Disclaimer In his capacity as the website owner and because of the full permissions that he has, all of the contents of the faculty member’s website including texts, images, researches and any other media are his responsibility. Therefore, the university disclaim any responsibility on this regard.
Copyright © Deanship of IT & Distance Learning 2018, 1440 H