The FDA on Monday approved Aprecia Pharmaceuticals' Spritam, which is the first 3-D printed product designed for use in the human body. The drug is intended to treat epileptic seizures, and its MIT-created delivery platform allows for oral administration in the form of a small tablet that dissolves quickly in liquid due to its porous nature.
Pennsylvania-based Aprecia--which operates a former Forest Laboratories plant in Ohio--gained the exclusive license to 3-D printing technology from MIT in the late 1980s, and by 2007 it began developing its ZipDose platform for drug delivery, an orodispersible structure that allows for easy-to-swallow tablets. It submitted its first NDA last October.
The new drug Spritam, designated to treat epilepsy, is a formulation of the commonly prescribed levetiracetam. Because of its rapid disintegration with a sip of liquid, it can deliver a high drug load of up to 1,000 mg in a single dose while at the same time conforming to the needs of patients with trouble swallowing, often small children. The company said it expects the product to be available in next year's first quarter.
The 3-D printing is a crucial part of the manufacturing process, in which layer upon layer of a powdered form of the drug form small tablets, a structure that gives it such a high degree of dissolvability in liquid. Also, because it is made entirely from the powdered drug, each pill has a uniform (and thus predictable) dose, especially important in a drug intended for the central nervous system.
published in: 2017-04-20 11:36:26
published in: 2017-02-16 09:18:23
published in: 2017-02-16 09:14:37
Starting today, a robot will dispense medication at the pharmacy of Rashid Hospital in Dubai.
Dubai Health Authority (DHA) recently inaugurated the robot pharmacy, which includes the robot that can dispense prescribed medication based on barcode reading.
The operation will be paper-free as the robot will store the prescription as soon as a doctor documents it electronically. The move is expected to minimise human error, and DHA is expected to adopt the robot's use across all its hospitals in the future.
According to a WAM report, the robot can store up to 35,000 medicines and dispense around 12 prescriptions in less than a minute.
Dr Ali Al Syed, director of the Pharmaceutical Services Department at DHA, said the robot "will significantly reduce a person’s waiting time" during the dispensing process.
published in: 2017-01-15 21:28:11
In a recommendation that reaffirms previous guidelines, the U.S. Preventive Services Task Force said that folic acid supplements reduce the risk of neural tube defects....
published in: 2017-01-11 14:04:34
Researchers at Columbia University Medical Center and the Data Science Institute at Columbia University have uncovered a potentially dangerous drug interaction using data science.Mining a government database of reported drug side effects and a university hospital archive of patient records, they discovered eight pairs of drugs that are associated with a higher risk of a potentially deadly heart condition. Testing one of the pairs on individual heart cells in the lab, they discovered why the drug combination may disrupt the heart's normal electrical activity in some patients. pair they studied - ceftriaxone, an antibiotic sold under the brand name Rocephin, and lansoprazole, a heartburn medication sold as Prevacid - are widely prescribed, and alone carry no known heart-related risks. But together, they may increase the chance that patients develop a heart condition known as long QT syndrome, which can cause abnormal heart rhythms and, in rare cases, sudden death. The study finds that patients taking ceftriaxone and lansoprazole together were 1.4 times more likely to have a prolonged QT interval than people who were taking either of these drugs alone...
published in: 2016-10-16 17:00:03
In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite - known as NAD - can produce multiple health benefits,
published in: 2016-10-11 10:33:58
For the eighth consecutive year, Roche (SIX: RO, ROG; OTCQX: RHHBY) has been recognised as Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry of the Dow Jones Sustainability Index (DJSI). This is based on an in-depth analysis of economic, social and environmental performance. The DJSI family of indices serves as a benchmark for investors who integrate sustainability considerations into their portfolios.
published in: 2016-10-06 16:08:52
Seventy-five percent of patients with moderate to severe alopecia areata - an autoimmune disease that causes patchy and, less frequently, total hair loss - had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center (CUMC). By the end of treatment, average hair regrowth among the patients was 92 percent. Findings from an open-label clinical trial of 12 patients with alopecia areata were published in the Journal of Clinical Investigation/Insight, alongside a paper reporting results of a separate study from Stanford University and Yale University that tested a similar drug....
published in: 2016-10-06 16:04:50
Researchers at MIT and other institutions have created tiny freeze-dried pellets that include all of the molecular machinery needed to translate DNA into proteins, which could form the basis for on-demand production of drugs and vaccines. The pellets, which contain dozens of enzymes and other molecules extracted from cells, can be stored for an extended period of time at room temperature. Upon the addition of water and freeze-dried DNA, the pellets begin producing proteins encoded by the DNA.
published in: 2016-10-06 16:02:58
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