Lectures
الإسم Another Details
INTRODUCTION TO PHARMACEUTICS AND DOSAGE FORM DESIGN

INTRODUCTION TO PHARMACEUTICS AND DOSAGE FORM DESIGN

Syllabus
PHT 224  -  PHARMACEUTICS I
Units Hours
Theoretical Practical
14 28 28
Course Catalog Description

The course is to introduce the dosage forms, prescriptions, mathematical and physicochemical principles of science to pharmacy students that can be applied to pharmaceutics and pharmacy practice. Principles of physics, chemistry, and mathematics are applied to the pharmaceutical sciences.

Course Requirements

Pre-requisites for this course

Math 109, Chem 105, Chem 106  

Textbook
  1. Comprehensive Pharmacy Review, Leon Shargel, 8th Edition, 2012 Lippincott Williams & Wilkins.
  2. Aulton's Pharmaceutics: The Design and Manufacture of Medicines, 3e, 2007
  3. Remington; The science and Practice of Pharmacy; 21st Edition, volume 1 & 2,  2005.
  4. Pharmaceutical Dosage Forms and Drug Delivery by H. C.Ansel, N. G. Popovich. 9th edition 2011.
  5. Pharmaceutical and Clinical Calculations, Mansoor A. Khan, Indra K. Reddy, 2nd Edition, 2000, CRC Press LLC
  6. Physical Pharmacy, Martin A. 5th Edition, 2006, Lippincott Williams & Wilkins.
  7. Pharmaceutics, the Science of dosage form design, Miclael E. Aulton 2005.
  8. Christian Leuner, Jennifer Dressman, Improving drug solubility for oral delivery using solid dispersions, European Journal of Pharmaceutics and Biopharmaceutics 50 (2000) 47-60.
  9. Chi H. Lee, Venkat Moturi and Yugyung Lee, Thixotropic property in pharmaceutical formulations, Journal of Controlled Release 136 (2009) 88–98.
Authers
  1. Comprehensive Pharmacy Review, Leon Shargel, 8th Edition, 2012 Lippincott Williams & Wilkins.
  2. Aulton's Pharmaceutics: The Design and Manufacture of Medicines, 3e, 2007
  3. Remington; The science and Practice of Pharmacy; 21st Edition, volume 1 & 2,  2005.
  4. Pharmaceutical Dosage Forms and Drug Delivery by H. C.Ansel, N. G. Popovich. 9th edition 2011.
  5. Pharmaceutical and Clinical Calculations, Mansoor A. Khan, Indra K. Reddy, 2nd Edition, 2000, CRC Press LLC
  6. Physical Pharmacy, Martin A. 5th Edition, 2006, Lippincott Williams & Wilkins.
  7. Pharmaceutics, the Science of dosage form design, Miclael E. Aulton 2005.
  8. Christian Leuner, Jennifer Dressman, Improving drug solubility for oral delivery using solid dispersions, European Journal of Pharmaceutics and Biopharmaceutics 50 (2000) 47-60.
  9. Chi H. Lee, Venkat Moturi and Yugyung Lee, Thixotropic property in pharmaceutical formulations, Journal of Controlled Release 136 (2009) 88–98.
Instructor

Dr. Mohammad Javed Ansari

Dr. Mohammad Khalid Anwer

Email:- mj.ansari@psau.edu.sa

m.anwer@psau.edu.sa

Grading Policy
Learning Outcome
Outcome Proficiency Assessment
   1 .  • Student should be able to recognize and calculate correctly the proportions (by weight or volume) of the different ingredients needed to prepare a given volume of any pharmaceutical preparation. • List and perform basic pharmaceutical dose calculations. • Describe greater understanding of students to apply the fundamental chemical, physical and mathematical principles to gain an understanding of the design of a number of dosage forms. Quizzes and examinations, both practical and theoretical.
   2 .  • Describe and recognize an understanding of interfacial phenomena and role of surfactant in these phenomena. • Describe and recognize an understanding of rheological property of material and its importance in the pharmaceutical industry. • Describe and recognize an understanding of drug kinetic and stability and how to calculate shelf life of drug. Quizzes and examinations, both practical and theoretical.
   3 .  The student should has the ability to: • Develop critical thinking and appropriate decision for problems. • Calculate the pharmaceutical doses correctly. • Recognize the physicochemical characters of different dosage forms Quizzes, Exams (theoretical and practical), home works, group discussions & assignments.
   4 .  • Explain the fundamentals of states of matter, solubility and distribution phenomena, Rheology. • Summarize the surface phenomenon, crystals and Polymorphism. • Evaluate various issues related to Drug Physical degradation of pharmaceutical products, Chemical decomposition, Storage conditions and containers and pharmacopeial specifications. Quizzes, Exams (theoretical and practical), homework, group discussions & assignments.
   5 .  At the end of the course the student should has the ability to: • Demonstrate good communication with instructors and staff. • Illustrate adequate communication with different personalities and attitudes. • Show ability to read the prescription and calculate the pharmaceutical doses. • Write an understanding of modern Physical pharmacy concepts. Practical Preparations, group discussions, home works & assignments.
   6 .  By the end of this course the student should have developed the skill to: • Illustrate a good reading for the medical prescription and its abbreviation precisely. • Present different Physical pharmacy topics. • Appraise ability to review updated Pharmaceutical issues. • Develop computer skills. • Peer and Supervisor Evaluation. • Monitoring the ability of the student to respond to questions in the lectures.
   7 .  • Illustrate a good use of the internet for scientific searches (Search utilizing internet to cope with course demand). • Use of the scientific web pages. • Follow the update knowledge concerning the course demand. • Demonstrate self-learning. • Peer and Supervisor Evaluation. • Monitoring the ability of the student to respond to questions in the lectures.
   8 .  Show the ability to use different Pharmaceutical instruments in the Lab to prepare and monitor different pharmaceutical preparations. Quizzes, Exams (especially for the practical part)
Topics
Week Description - Reading  
1-14

1 Topics to be Covered

List of Topics

Week

Contact hours

Introduction to pharmaceutics & dosage forms

1

5-2-2017

Fundamentals of weights and measurement

2

12-2-2017

Conversions of weights and measurement

3

19-2-2017

Interpretation of prescription

4

26-2-2017

Conversions and calculations of doses in prescriptions

5

5-3-2017

Pediatric dosage calculations &conversions

6

12- 3- 2017

Exam 1

7

19- 3- 2017

State of the matters & solid-state roperties

8

26- 3- 2017

Solublization & Solubility expressions

9

2- 4- 2017

Colligative properties of solutions

10

    9- 4- 2017

Liquid-state properties

11

16- 4- 2017

Exam 2

12

23- 4- 2017

Rheology

13

30- 4- 2017

Surface and Interfacial phenomenon

14

7- 5- 2017

Surface and Interfacial phenomenon

15

14- 5- 2017

Reaction Kinetics & drug stability

16

21- 5- 2017

Total

16

28


Reading:

1 Topics to be Covered

List of Topics

Week

Contact hours

Introduction to pharmaceutics & dosage forms

1

5-2-2017

Fundamentals of weights and measurement

2

12-2-2017

Conversions of weights and measurement

3

19-2-2017

Interpretation of prescription

4

26-2-2017

Conversions and calculations of doses in prescriptions

5

5-3-2017

Pediatric dosage calculations &conversions

6

12- 3- 2017

Exam 1

7

19- 3- 2017

State of the matters & solid-state roperties

8

26- 3- 2017

Solublization & Solubility expressions

9

2- 4- 2017

Colligative properties of solutions

10

    9- 4- 2017

Liquid-state properties

11

16- 4- 2017

Exam 2

12

23- 4- 2017

Rheology

13

30- 4- 2017

Surface and Interfacial phenomenon

14

7- 5- 2017

Surface and Interfacial phenomenon

15

14- 5- 2017

Reaction Kinetics & drug stability

16

21- 5- 2017

Total

16

28