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Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points ...
Colorectal cancer prognosis depends on T-cell infiltration and molecular characteristics of the tumor
The aim of this study was to relate the density of tumor infiltrating T cells to cancer-specific survival in colorectal cancer, taking into consideration the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) screening status...
High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis
an active stroma is important for cancer cell invasion and metastasis. We investigated the expression of fibroblast activation protein (FAP) in relation to patient prognosis in colorectal cancer. Colorectal cancer specimens from 449 patients were immunohistochemically stained with a FAP antibody and evaluated in the tumor center and tumor front...
Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity...
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