أعضاء هيئة التدريس | مواقع أعضاء هيئة التدريس

د.محمد حامد سعيد القرنى

PhD pharmaceutical sciences استاذ مشارك قسم العقاقير كلية الصيدلة بالخرج

الخرج
011-588-6011
m.alqarni@psau.edu.sa

السيرة الذاتية
الأبحاث العلمية

المؤهلات العلمية

PhD. School of Pharmacy - University of Pittsburgh
B.S. School of Pharmacy- King Saud University, Saudi Arabia

الاهتمامات البحثية

Chromatography: TLC, Open column chromatography, Gel Chromatography (Sephadex and Polyamide support), Preparative HPLC.
Protein analysis: Cell culturing (Bacterial and Viral culturing), computer simulation and modeling, fast protein liquid chromatography (FPLC) and protein analysis (circular dichroism spectroscopy).

مهام ومسؤوليات

رئيس قسم العقاقير - كلية الصيدلة

الأبحاث العلمية

.A. Dound, S. Chaudhary, S.S. Chaudhary, S. Rawat, M.H. Alqarni, M.M. Ahmad, M.H. Geesi, P. Alam, Mechanistic understanding of PtyroneTM: A plant based natural anti diabetic product, J King Saud Univ Sci, 33 (2021).
2. A.K. Garg, B. Maddiboyina, M.H.S. Alqarni, A. Alam, H.M. Aldawsari, P. Rawat, S. Singh, P. Kesharwani, Solubility enhancement, formulation development and antifungal activity of luliconazole niosomal gel-based system, J Biomat Sci-Polym E, 32 (2021) 1009-1023.
3. M. Platis, D. Vlachakis, A.I. Foudah, M.M. Muharram, M.H. Alqarni, A.C. Papageorgiou, N.E. Labrou, The Interaction of Schistosoma japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments, Med Chem, 17 (2021) 332-343.
4. M.H. Alqarni, A.I. Foudah, M.M. Muharram, H. Budurian, N.E. Labrou, Probing the Role of the Conserved Arg174 in Formate Dehydrogenase by Chemical Modification and Site-Directed Mutagenesis, Molecules, 26 (2021).
5. M.H. Alqarni, A.I. Foudah, M.M. Muharram, N.E. Labrou, The Interaction of the Flavonoid Fisetin with Human Glutathione Transferase A1-1, Metabolites, 11 (2021).
6. M.H. Alqarni, A.I. Foudah, M.M. Muharram, N.E. Labrou, The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes, Molecules, 26 (2021).
7. P. Alam, M.M. Salem-Bekhit, F.A. Al-Joufi, M.H. Alqarni, F. Shakeel, Quantitative analysis of cabozantinib in pharmaceutical dosage forms using green RP-HPTLC and green NP-HPTLC methods: A comparative evaluation, Sustain Chem Pharm, 21 (2021).
8. P. Alam, F. Shakeel, M.H. Alqarni, A.I. Foudah, M. Faiyazuddin, S. Alshehri, Rapid, Sensitive, and Sustainable Reversed-Phase HPTLC Method in Comparison to the Normal-Phase HPTLC for the Determination of Pterostilbene in Capsule Dosage Form, Processes, 9 (2021).
9. M.H. Alqarni, P. Alam, A.I. Foudah, M.M. Muharram, F. Shakeel, Combining Normal/Reversed-Phase HPTLC with Univariate Calibration for the Piperine Quantification with Traditional and Ultrasound-Assisted Extracts of Various Food Spices of Piper nigrum L. under Green Analytical Chemistry Viewpoint, Molecules, 26 (2021).
10. A.I. Foudah, F. Shakeel, M.H. Alqarni, S.A. Ross, M.A. Salkini, P. Alam, Green NP-HPTLC and green RP-HPTLC methods for the determination of thymoquinone: A contrast of validation parameters and greenness assessment, Phytochem Analysis, (2021).
11. A.I. Foudah, F. Shakeel, M.H. Alqarni, S.A. Ross, M.A. Salkini, P. Alam, Simultaneous Estimation of Cinnamaldehyde and Eugenol in Essential Oils and Traditional and Ultrasound-Assisted Extracts of Different Species of Cinnamon Using a Sustainable/Green HPTLC Technique, Molecules, 26 (2021).
12. M. Ghazwani, M.Y. Begum, P. Alam, M.H. Alqarni, H.S. Yusufoglu, F. Shakeel, Solubility Determination, Hansen Solubility Parameters and Thermodynamic Evaluation of Thymoquinone in (Isopropanol plus Water) Compositions, Molecules, 26 (2021).
13. M. Ghazwani, P. Alam, M.H. Alqarni, H.S. Yusufoglu, F. Shakeel, Solubilization of Trans-Resveratrol in Some Mono-Solvents and Various Propylene Glycol plus Water Mixtures, Molecules, 26 (2021).
14. P. Alam, M.M. Salem-Bekhit, M. Iqbal, M.K. Anwer, M.H. Alqarni, F. Shakeel, Stability-indicating reversed-phase/normal-phase high-performance thin-layer chromatography technique for the determination of arbidol: Green analytical chemistry viewpoint, J Chin Chem Soc-Taip, 68 (2021) 1709-1721.
15. M. Khalid, M.H. Alqarni, A. Shoaib, M. Arif, A.I. Foudah, O. Afzal, A. Ali, A. Ali, S.S. Alqahtani, A.S.A. Altamimi, Anti-Arthritic and Anti-Inflammatory Potential of Spondias mangifera Extract Fractions: An In Silico, In Vitro and In Vivo Approach, Plants-Basel, 10 (2021).
16. A.I. Foudah, F. Shakeel, P. Alam, M.H. Alqarni, M.S. Abdel-Kader, S. Alshehri, A Sustainable Reversed-Phase HPTLC Method for the Quantitative Estimation of Hesperidin in Traditional and Ultrasound-Assisted Extracts of Different Varieties of Citrus Fruit Peels and Commercial Tablets, Agronomy-Basel, 11 (2021).
17. A.I. Foudah, M.H. Alqarni, A. Alam, M.A. Salkini, E.O.I. Ahmed, H.S. Yusufoglu, Evaluation of the composition and in vitro antimicrobial, antioxidant, and anti-inflammatory activities of Cilantro (Coriandrum sativum L. leaves) cultivated in Saudi Arabia (Al-Kharj), Saudi J Biol Sci, 28 (2021) 3461-3468.
18. P. Alam, F. Shakeel, M.H. Alqarni, A.I. Foudah, A rapid and highly sensitive stability-indicating high-performance thin-layer chromatography technique for the determination of tedizolid phosphate with a classical univariate calibration, Jpc-J Planar Chromat, 34 (2021) 271-278.
19. A.I. Foudah, F. Shakeel, M.H. Alqarni, P. Alam, A rapid and sensitive stability-indicating green RP-HPTLC method for the quantitation of flibanserin compared to green NP-HPTLC method: Validation studies and greenness assessment, Microchem J, 164 (2021).
20. P. Alam, M.H. Alqarni, F. Shakeel, Phytochemical Analysis, Standardization and Antidiabetic Effects of Tinospora cordifolia Stems, Lat Am J Pharm, 40 (2021) 1931-1938.
21. M.H. Alqarni, P. Alam, F. Shakeel, A.I. Foudah, S. Alshehri, Highly Sensitive and Ecologically Sustainable Reversed-Phase HPTLC Method for the Determination of Hydroquinone in Commercial Whitening Creams, Processes, 9 (2021).
22. M.H. Alqarni, N. Haq, P. Alam, M.S. Abdel-Kader, A.I. Foudah, F. Shakeel, Solubility data, Hansen solubility parameters and thermodynamic behavior of pterostilbene in some pure solvents and different (PEG-400+water) cosolvent compositions, J Mol Liq, 331 (2021).
23. M.S. Abdel-Kader, M.H. Alqarni, A.I. Foudah, New Flavonoids from Saudi collection of Tephrosia purpurea L. (Pers.), Rec Nat Prod, 15 (2021) 293-300.
24. P. Alam, M.T. Alanazi, H.H. Zaatout, M.H. Alqarni, M.S. Abdel-Kader, Densitometric high-performance thin-layer chromatography methods for the quantification of oleuropein in Olea europaea leaves and pharmaceutical preparation utilizing normal- and reversed-phase silica gel plates (vol 33, pg 609, 2020), Jpc-J Planar Chromat, (2021).
25. M.H. Alqarni, A.I. Foudah, A. Alam, M.A. Salkini, P. Alam, H.S. Yusufoglu, Novel HPTLC-densitometric method for concurrent quantification of linalool and thymol in essential oils, Arab J Chem, 14 (2021).
26. M. Khalid, M.H. Alqarni, A.I. Foudah, P. Alam, A high-performance thin-layer chromatography method for the simultaneous determination of quercetin and gallic acid in Eclipta alba and Guiera senegalensis, Jpc-J Planar Chromat, 34 (2021) 71-77.
27. M.M. Muharram, A.T. Abulhamd, M.F. Aldawsari, M.H. Alqarni, N.E. Labrou, Development of Staphylococcus Enzybiotics: The Ph28 Gene of Staphylococcus epidermidis Phage PH15 Is a Two-Domain Endolysin, Antibiotics-Basel, 9 (2020).
28. A.I. Foudah, M.H. Alqarni, G.A. Soliman, R.F. Abdel-Rahman, O. Alankus-Caliskan, M.A. Ganaie, H. Yusufoglu, The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats, J Pharm Res Int, 32 (2020) 102-114.
29. P. Alam, E. Ezzeldin, M. Iqbal, G.A.E. Mostafa, M.K. Anwer, M.H. Alqarni, A.I. Foudah, F. Shakeel, Determination of Delafloxacin in Pharmaceutical Formulations Using a Green RP-HPTLC and NP-HPTLC Methods: A Comparative Study, Antibiotics-Basel, 9 (2020).
30. M.H. Alqarni, G.A. Soliman, M.A.A. Salkini, P. Alam, H.S. Yusufoglu, S. Baykan, B. Ozturk, M.S. Abdel-Kader, The Potential Aphrodisiac Effect of Ferula drudeana Korovin Extracts and Isolated Sesquiterpene Coumarins in Male Rats, Pharmacogn Mag, 16 (2020) S404-S409.
31. M.H. Alqarni, M. Ghazwani, M.K. Anwer, F. Shakeel, P. Alam, Determination of Sunitinib Malate in Nanoparticles Formulation Using HPTLC-Densitometry Technique, Lat Am J Pharm, 39 (2020) 2279-2284.
32. P. Alam, M.H. Alqarni, P. Alam, A.I. Foudah, M. Ghazwani, A HPTLC Method for Determination of Anethole in Essential Oil, Methanolic Extract of Foeniculum vulgare and Commercial Herbal Products, J Pharm Res Int, 32 (2020) 68-75.
33. M. Khalid, M.H. Alqarni, A.I. Foudah, J. Akhtar, Badruddeen, A. Shoaib, P. Alam, Evaluation of Free Radical Scavenging Potential of Different Bioactive Fractions Present in Boerhavia diffusa Linn. Root Extract: An in-vitro Approach, J Pharm Res Int, 32 (2020) 99-107.
34. P. Alam, N. Haq, M.H. Alqarni, F. Shakeel, Quantitative Analysis of Emtricitabine in Dosage Forms Using Green RP-HPTLC and Routine NP-HPTLC Methods-A Contrast of Validation Parameters, ACS Omega, 5 (2020) 33470-33477.
35. A.I. Foudah, F. Shakeel, M.H. Alqarni, H.S. Yusufoglu, M.A. Salkini, P. Alam, Determination of Trans-Anethole in Essential Oil, Methanolic Extract and Commercial Formulations of Foeniculum vulgare Mill Using a Green RP-HPTLC-Densitometry Method, Separations, 7 (2020).
36. M. Khalid, A. Shoaib, J. Akhtar, M.H. Alqarni, Badruddeen, H.H. Siddiqui, A.I. Foudah, Anti obesity prospective of Dalbergia latifolia (Roxb.) hydroalcoholic bark extract in high fat diet induced obese rats, 3 Biotech, 10 (2020) 493.
37. P. Alam, M. Iqbal, E. Ezzeldin, N.Y. Khalil, A.I. Foudah, M.H. Alqarni, F. Shakeel, Simple and Accurate HPTLC-Densitometric Method for Quantification of Delafloxacin (A Novel Fluoroquinolone Antibiotic) in Plasma Samples: Application to Pharmacokinetic Study in Rats, Antibiotics (Basel), 9 (2020).
38. P. Alam, M. Iqbal, A.I. Foudah, M.H. Alqarni, F. Shakeel, Quantitative determination of canagliflozin in human plasma samples using a validated HPTLC method and its application to a pharmacokinetic study in rats, Biomed Chromatogr, 34 (2020) e4929.
39. P. Alam, P. Alam, M.A. Sharaf-Eldin, M.H. Alqarni, Simultaneous identification of rutin, chlorogenic acid and gallic acid in Moringa oleifera by densitometric high-performance thin-layer chromatography method, Jpc-J Planar Chromat, 33 (2020) 27-32.
40. A.I. Foudah, P. Alam, F. Shakeel, S.I. Alqasoumi, M.H. Alqarni, H.S. Yusufoglu, Eco-Friendly RP-HPTLC Method for Determination of Valerenic Acid in Methanolic Extract of Valeriana officinalis and Commercial Herbal Products, Lat Am J Pharm, 39 (2020) 420-424.
41. P. Alam, E. Ezzeldin, M. Iqbal, M.K. Anwer, G.A.E. Mostafa, M.H. Alqarni, A.I. Foudah, F. Shakeel, Ecofriendly densitometric RP-HPTLC method for determination of rivaroxaban in nanoparticle formulations using green solvents, Rsc Adv, 10 (2020) 2133-2140.
42. A.I. Foudah, P. Alam, Y.T. Kamal, S.I. Alqasoumi, M.H. Alqarni, S.A. Ross, H.S. Yusufoglu, Development and validation of a high-performance thin-layer chromatographic method for the quantitative analysis of vitexin in Passiflora foetida herbal formulations, Saudi Pharm J, 27 (2019) 1157-1163.
43. P. Alam, M.S. Abdel-Kader, M.H. Alqarni, H.H. Zaatout, S.R. Ahamad, F. Shakeel, Chemical composition of fennel seed extract and determination of fenchone in commercial formulations by GC-MS method, J Food Sci Tech Mys, 56 (2019) 2395-2403.
44. P. Alam, Y.T. Kamal, S.I. Alqasoumi, A.I. Foudah, M.H. Alqarni, H.S. Yusufoglu, HPTLC method for simultaneous determination of ascorbic acid and gallic acid biomarker from freeze dry pomegranate juice and herbal formulation, Saudi Pharm J, 27 (2019) 975-980.
45. M.S. Abdel-Kader, A.M. Hamad, M.T. Alanazi, A.H. Alanazi, R. Ali, A.I. Foudah, M.H. Alqarni, Characterization and hepatoprotective evaluation of sesquiterpenes and diterpenes from the aerial parts of Juniperus sabina L., Saudi Pharm J, 27 (2019) 920-929.
46. M.S. Abdel-Kader, G.A. Soliman, M.H. Alqarni, A.M. Hamad, A.I. Foudah, S.I. Alqasoumi, Chemical composition and protective effect of Juniperus sabina L. essential oil against CCl4 induced hepatotoxicity, Saudi Pharm J, 27 (2019) 945-951.
47. A.I. Foudah, P. Alam, M.H. Alqarni, M.A.A. Salkini, M.S. Abdel-Kader, Development of a Reversed-Phase High-Performance Thin-Layer Chromatography Method for the Simultaneous Determination of Trigonelline and Diosgenin Biomarkers in Trigonella foenum-graecum L. Seeds Grown in Variable Environment, Jpc-J Planar Chromat, 32 (2019) 379-384.
48. M.H. Alqarni, P. Alam, A.M. Al Kharji, M.A.A. Salkini, M.S. Abdel-Kader, Effect of Environmental Conditions on the Biomarker Trigonelline in Trigonella foenum-graecum L. seeds Using Validated HPTLC Method, Curr Pharm Anal, 16 (2020) 698-704.
49. M.H. Alqarni, A.I. Foudah, A. Alam, M.A. Salkini, O.A.O. Elmakki, H.S. Yusufoglu, Contribution to the Quality Control and in-Vitro Antioxidant Activity of Leaves of Petroselinum Crispum and Coriandrum Sativum Cultivated in Saudi Arabia, Int J Pharm Sci Res, 10 (2019) 4158-4166.
50. F. Shakeel, P. Alam, M.K. Anwer, S. Alanazi, I.A. Alsarra, M.H. Alqarni, Wound healing evaluation of self-nanoemulsifying drug delivery system containing Piper cubeba essential oil, 3 Biotech, 9 (2019).
51. M.H. Alqarni, M.M. Muharram, S.M. Alshahrani, N.E. Labrou, Copper-induced oxidative cleavage of glutathione transferase F1-1 from Zea mays, Int J Biol Macromol, 128 (2019) 493-498.
52. A.I. Foudah, M. H Alqarni, A. Alam, M.A. Salkini, E.O. Ahmed, H. Yusufoglu, Evaluation of in Vitro Antioxidant and Antimicrobial Activities of Methanol Extract of Standardized Lactuca Sativa L. Leaves, Indo Am J Pharm Sci, 6 (2019) 4277-4290.
53. M.S. Abdel-Kader, K.S. Al Shahrani, M.H. Alqarni, M.A. Salkini, E.H. Khamis, H.A. Ghabbour, S.I. Alqasoumi, Effect of hydroxylated solvents on the active constituents of Salvadora persica root "Siwak", Saudi Pharm J, 27 (2019) 220-224.
54. M.H. Alqarni, P. Alam, M.A. Salkini, M.S. Abdel-Kader, Roasting Effect on the Caffeine Contents and Antioxidant Potential of Different Coffee Grades Available in the Saudi Market, Indo Am J Pharm Sci, 5 (2018) 16738-16745.
55. M.H. Alqarni, M.M. Muharram, N.E. Labrou, Ligand-induced glutathione transferase degradation as a therapeutic modality: Investigation of a new metal-mediated affinity cleavage strategy for human GSTP1-1, Int J Biol Macromol, 116 (2018) 84-90.
56. Y.T. Kamal, P. Alam, S.I. Alqasoumi, A.I. Foudah, M.H. Alqarni, H.S. Yusufoglu, Investigation of antioxidant compounds in commercial pomegranate molasses products using matrix-solid phase dispersion extraction coupled with HPLC, Saudi Pharm J, 26 (2018) 839-844.
57. P. Alam, F. Shakeel, M.K. Anwer, A.I. Foudah, M.H. Alqarni, Wound Healing Study of Eucalyptus Essential Oil Containing Nanoemulsion in Rat Model, J Oleo Sci, 67 (2018) 957-968.
58. M.S. Abdel-Kader, E.H. Khamis, A.I. Foudah, M.H. Alqarni, GC quantitative analysis of benzyl isothiocyanate in Salvadora persica roots extract and dental care herbal products, Saudi Pharm J, 26 (2018) 462-466.
59. H.S. Yusufoglu, G.A. Soliman, A.I. Foudah, M.S. Abdel-Kader, M.H. Alqarni, A. Alam, M.A. Salkini, Standardization and Antioxidant Studies of Arnebia hispidissima, Int J Pharmacol, 14 (2018) 428-436.
60. P. Alam, Y.T. Kamal, M.H. Alqarni, H.H. Zaatout, M.S. Abdel-Kader, Reversed-Phase High-Performance Thin-Layer Chromatographic Method for the Simultaneous Determination of Glycyrrhizin and Glabridin Biomarkers in Glycyrrhiza glabra Roots, Rhizomes and Herbal Formulations, Jpc-J Planar Chromat, 31 (2018) 135-142.
61. H.S. Yusufoglu, M.N. Ansari, G.A. Soliman, A.I. Foudah, M.H. Alqarni, A. Alam, M.A. Salkini, Cardioprotective and Nephroprotective Actions of Methanolic Extract of Pulicaria Somalensis Herbs against Carbon Tetrachloride Induced Toxicity in Rats, Indo Am J Pharm Sci, 5 (2018) 2811-2823.
62. M.S. Abdel-Kader, P. Alam, M.H. Alqarni, M.A. Salkini, High-Performance Thin-Layer Chromatographic Method for the Estimation of Benzyl Isothiocyanate in Salvadora persica Root Extract and Dental Care Herbal Products, Jpc-J Planar Chromat, 30 (2017) 211-215.
63. M.S. Abdel-Kader, M.M. Muharram, A.I. Foudah, M.H. Alqarni, M.A. Salkini, Antimicrobial Isothiocyanate Derivatives from Salvadora Persica Root "Siwak" Extract, Indo Am J Pharm Sci, 4 (2017) 1224-1228.
64. M.S. Abdel-Kader, Y.T. Kamal, P. Alam, M.H. Alqarni, A.I. Foudah, Quantitative Analysis of Benzyl Isothiocyanate in Salvadora persica Extract and Dental Care Herbal Formulations Using Reversed Phase C18 High-Performance Liquid Chromatography Method, Pharmacogn Mag, 13 (2017) S412-S416.
65. J.P. Hu, Z.W. Feng, S.F. Ma, Y. Zhang, Q. Tong, M.H. Alqarni, X.J. Gou, X.Q. Xie, Difference and Influence of Inactive and Active States of Cannabinoid Receptor Subtype CB2: From Conformation to Drug Discovery, J Chem Inf Model, 56 (2016) 1152-1163.
66. Z.W. Feng, M.H. Alqarni, P. Yang, Q. Tong, A. Chowdhury, L.R. Wang, X.Q. Xie, Modeling, Molecular Dynamics Simulation, and Mutation Validation for Structure of Cannabinoid Receptor 2 Based on Known Crystal Structures of GPCRs, J Chem Inf Model, 54 (2014) 2483-2499.
67. M.H. Alqarni, K.Z. Myint, Q. Tong, P. Yang, P. Bartlow, L.R. Wang, R.T. Feng, X.Q. Xie, Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activities, Biochem Bioph Res Co, 452 (2014) 334-339.
68. P. Yang, K.Z. Myint, Q. Tong, R.T. Peng, H.P. Cao, A.A. Almehizia, M.H. Alqarni, L.R. Wang, P. Bartlow, Y.D. Gao, J. Gertsch, J. Teramachi, N. Kurihara, G.D. Roodman, T. Cheng, X.Q. Xie, Lead Discovery, Chemistry Optimization, and Biological Evaluation Studies of Novel Biamide Derivatives as CB2 Receptor Inverse Agonists and Osteoclast Inhibitors, J Med Chem, 55 (2012) 9973-9987.

مواقع أعضاء هيئة التدريس

د.محمد حامد سعيد القرنى

المؤهلات العلمية

الاهتمامات البحثية

مهام ومسؤوليات

الأبحاث العلمية

تواصل مع قيادات الجامعة

إدارة العلاقات العامة والإعلام

Social

مواقع أعضاء هيئة التدريس

د.محمد حامد سعيد القرنى

المؤهلات العلمية

الاهتمامات البحثية

مهام ومسؤوليات

الأبحاث العلمية

إدارة العلاقات العامة والإعلام