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Brain tissue integrity and the use of new oral therapies in RRMS

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This review shows the brain tissue integrity data and safety profile of new oral agents for treatment of of RRMS such as: BG-12 , Teriflunomide, Fingolimod,Laquinimod Natalizumab

DEFINE and CONFIRM study shows BG-12 and Fingolimod more effective in reduction of progression and remession clinically and radiologically than placebo among RRMS patient

The patients must be screened with cardiological assesment if they have risk of cardiovascular diseases or on antiarrythmic medications before fingolimod therapy for safety.

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