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Sulfasalazine in recalcitrant chronic urticaria

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Sulfasalazine, an antiinflammatory agent, is used to treat chronic urticaria (CU) that is refractory to antihistamines, although data on efficacy are lacking. The impact of sulfasalazine as add-on therapy in recalcitrant CU was examined in a retrospective review of 31 patients, representing the largest study to date. Sulfasalazine was added to the patients' existing therapies, and if symptoms were controlled, therapies other than antihistamines were reduced/discontinued. Symptoms improved in 84 percent within three months and were completely controlled in 51 percent by six months. Nine of 10 steroid-dependent patients discontinued glucocorticoids. Although randomized trials are needed, this study suggests that sulfasalazine has utility in recalcitrant CU and may reduce dependence on more toxic agents, such as glucocorticoids

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Books and literature

Advice for medical students interested in dermatology: perspectives from fourth year students who matched.

Advice for medical students interested in dermatology: perspectives from fourth year students who matched.

This paper provides valuable suggestions and guidance to students considering a career in dermatology.

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Scientific Research

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